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Application of mesenchymal stem cell-derived small extracellular vesicles overexpressing interleukin 10 in preparation of drugs for treating autoimmune diseases

An autoimmune, stromal stem cell technology, applied in the application field of mesenchymal stem cell-derived small extracellular vesicles in the treatment of autoimmune diseases, can solve problems such as undiscovered patent documents, and achieve the promotion of innovative development, Strong therapeutic effect, easy transportation and preservation effect

Pending Publication Date: 2020-08-11
天津医科大学眼科医院
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0007] Through searching, no published patent documents related to this patent application have been found

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  • Application of mesenchymal stem cell-derived small extracellular vesicles overexpressing interleukin 10 in preparation of drugs for treating autoimmune diseases
  • Application of mesenchymal stem cell-derived small extracellular vesicles overexpressing interleukin 10 in preparation of drugs for treating autoimmune diseases
  • Application of mesenchymal stem cell-derived small extracellular vesicles overexpressing interleukin 10 in preparation of drugs for treating autoimmune diseases

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Embodiment Construction

[0039] The embodiments of the present invention will be described in detail below. It should be noted that the embodiments are illustrative, not restrictive, and cannot limit the protection scope of the present invention.

[0040]The raw materials used in the present invention, unless otherwise specified, are conventional commercially available products; the methods used in the present invention, unless otherwise specified, are conventional methods in the art.

[0041] The mesenchymal stem cell-derived small extracellular vesicles overexpressing interleukin 10 are used in the preparation of drugs for treating autoimmune diseases.

[0042] Preferably, the autoimmune disease is autoimmune uveitis or multiple sclerosis.

[0043] The mesenchymal stem cell-derived small extracellular vesicles overexpressing interleukin 10 are used in the preparation of drugs for inhibiting T cell proliferation.

[0044] The mesenchymal stem cell-derived small extracellular vesicles overexpressing ...

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Abstract

The invention relates to application of mesenchymal stem cell-derived small extracellular vesicles overexpressing interleukin 10 in preparation of drugs for treating autoimmune diseases. The MSCs-derived sEVs overexpressing IL-10 not only have the common characteristics and advantages of sEVs, such as easy transportation and storage, repeated freezing and thawing, low immunogenicity and the like,but also combine the strong immunosuppressive capacity of IL-10, so that the MSCs-derived sEVs overexpressing IL-10 has a great potential clinical application value and has the potential of being developed into a new clinical biological preparation, and the innovation and development of ophthalmic drugs are promoted. In addition, sEVs are found to have inflammation chemotactic ability and can be focused to diseased organs to play an immunosuppressive role.

Description

technical field [0001] The invention belongs to the field of cell technology, in particular to the application of small extracellular vesicles derived from mesenchymal stem cells overexpressing interleukin 10 in the treatment of autoimmune diseases. Background technique [0002] Autoimmune disease is a kind of disease in which the body produces an immune response against self-antigens and causes damage to its own tissues. The occurrence of autoimmune diseases is mainly due to the destruction of the autoimmune tolerance mechanism, the body produces antibodies against self-antigens or autoimmune cells attack its own tissues, resulting in serious tissue damage and dysfunction. Common autoimmune diseases include autoimmune uveitis, multiple sclerosis, systemic lupus erythematosus, and rheumatoid arthritis. [0003] The current traditional drugs for the treatment of autoimmune diseases mainly include glucocorticoids and immunosuppressants. However, both of them have many side e...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/28A61K38/20A61P37/00A61P27/02A61P37/02A61P37/06
CPCA61K35/28A61K38/2066A61P37/00A61P27/02A61P37/02A61P37/06A61K2300/00
Inventor 张晓敏李筱荣任新军栗勇涛张智慧刘拥军
Owner 天津医科大学眼科医院
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