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Preparation method of arbutin in Quezui tea and application of arbutin in treatment of hyperuricemia

A technology of arbutin and sparrow mouth tea, applied in the field of medicine, can solve the problems of anti-hyperuricemia and related diseases that have not been reported yet

Inactive Publication Date: 2020-08-14
HUAQIAO UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Therefore, the current arbutin-related patents that have been seen so far mainly focus on the preparation method, detection method and application of arbutin in cosmetics, but its role in the preparation of anti-hyperuricemia and related diseases has not yet been established. See the report

Method used

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  • Preparation method of arbutin in Quezui tea and application of arbutin in treatment of hyperuricemia
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  • Preparation method of arbutin in Quezui tea and application of arbutin in treatment of hyperuricemia

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Experimental program
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Embodiment 1

[0031] Preparation of arbutin

[0032] Step 1. Take 5 kg of dried sparrow mouth tea as a raw material, pulverize it with a pulverizer, add 50 L and 60% ethanol to soak for three times, filter under reduced pressure after each soak, and combine the recovered filtrate to obtain 2.32 kg of medicinal extract;

[0033] Step 2, then dissolve the extract of the extract in 8L of distilled water to form a suspension, extract with 8L of ethyl acetate solvent, mix well and let it stand overnight after contacting, take the upper ethyl acetate layer after layering, and the lower layer The water layer was continuously added with an equal volume of ethyl acetate for extraction, and after repeated extraction three times, the collected ethyl acetate layers were combined to obtain 0.76 kg of ethyl acetate extract and 1.36 kg of water layer sample;

[0034] Step 3. Then heat and dissolve the water layer sample with 3L of methanol, add 2kg of 200-300 mesh column chromatography silica gel and mix ...

Embodiment 2

[0040] Arbutin reduces serum uric acid (UA) level in hyperuricemia model mice

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Abstract

The invention discloses a preparation method of arbutin in Quezui tea and application of the arbutin in treatment of hyperuricemia. A monomeric compound arbutin is obtained by directional extraction and separation from the Quezui tea, and an arbutin acquiring way is provided. The invention also discloses application of the arbutin in treatment of hyperuricemia, namely, the new application of the arbutin in treatment of hyperuricemia. The invention provides a new drug guide, a preparation method and medical application for the arbutin in treatment of the hyperuricemia and related diseases.

Description

technical field [0001] The invention belongs to the technical field of medicine, in particular to a method for preparing arbutin from sparrow mouth tea and the application of arbutin in anti-hyperuricemia and related disease drugs. Background technique [0002] Hyperuricemia is a metabolic disease caused by increased uric acid synthesis and / or decreased uric acid excretion. It refers to fasting blood uric acid levels higher than 420 μmol / L twice on different days under a normal purine diet. A Meta-analysis was conducted on the prevalence of hyperuricemia in the Chinese population, and the results showed that the prevalence of hyperuricemia in Chinese males and females was 21.6% and 8.6%, respectively, and the total prevalence was 13.3%. 130 million. [0003] Gout is strongly associated with obesity, chronic kidney disease, hypertension, type 2 diabetes, dyslipidemia, heart disease (including coronary heart disease, heart failure, and atrial fibrillation), stroke, and periph...

Claims

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Application Information

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IPC IPC(8): C07H15/203C07H1/08A61K31/7034A61P13/04A61P19/06
CPCA61K31/7034A61P13/04A61P19/06C07H1/08C07H15/203
Inventor 刘接卿凌琳连晨蕾李招发马俊杰吴四海米雪
Owner HUAQIAO UNIVERSITY
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