Use of flot2 inhibitors to inhibit osteoclastogenesis and/or osteoclastic activity

A technology for inhibiting osteoclast and cell activity, applied in the field of biomedicine, and can solve the problem of unreported effects on bone cells
CN111569077BActive Publication Date: 2021-10-26SOUTHERN MEDICAL UNIVERSITY
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
SOUTHERN MEDICAL UNIVERSITY
Publication Date
2021-10-26

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Abstract

The present invention discloses for the first time the application of Flot2 inhibitors in inhibiting osteoclast formation and / or osteoclast activity, and can significantly reduce RANKL-induced osteoclastogenesis and bone resorption after Flot2 expression is inhibited by specific interference of Flot2-siRNA. The inventor's research team found that Flot2 is directly involved in osteoclast formation and bone resorption, and may become a new target for osteoclast differentiation inhibitors. Based on the inhibitory effect of Flot2‑siRNA on osteoclasts and the application prospect of RNA interference drugs, the application of Flot2 inhibitors as drugs for inhibiting osteoclastogenesis is provided.
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Description

technical field

[0001] The invention relates to the field of biomedicine, more specifically, the invention relates to the application of Flot2 gene inhibitors in inhibiting osteoclast formation and / or osteoclast activity. Background technique

[0002] The stabilization of bone metabolism requires a dynamic balance and coupling between bone resorption mediated by osteoclasts (OCs) and bone formation mediated by osteoblasts (OBs), which maintain function in healthy individuals Balance, and once the balance is broken, it may lead to the occurrence of bone diseases.

[0003] Osteoclasts are the only cells in the body responsible for bone resorption. It can differentiate into functional mature osteoclasts from osteoclast precursor cells after activation. Because differentiated and mature osteoclasts can absorb bone, their excessive activation can cause bone loss, osteoporosis, fracture pain, secondary reactive bone hyperplasia, and even disability. There are many diseases rela...

Claims

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