A kind of gynecological disinfectant and preparation method thereof

A disinfectant, gynecological technology, applied in pharmaceutical formulations, medical preparations with non-active ingredients, and medical preparations containing active ingredients, etc., can solve the problems of poor durability, weak mold effect, narrow sterilization spectrum, etc., to increase retention time, increased action time, long action time effect

Active Publication Date: 2021-03-16
WUHAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among them, the ethanol solution with a concentration of 60-80% has the best bactericidal effect, but its persistence is poor and its bactericidal spectrum is narrow; iodine and iodine preparations have a good bactericidal effect, but they are easy to color on the skin, mucous membranes or clothing, causing the problem of difficult elution. are usually used as topical antiseptics
Chlorhexidine and quaternary ammonium compounds have a narrow bactericidal spectrum and are less effective against Gram-negative bacteria. In addition, chlorhexidine has a weaker effect on mold
Triclosan has a broad antibacterial spectrum, but its bactericidal effect is weak
However, many disinfectants on the market are not selective, and lead to pH imbalance, killing many beneficial bacteria. Therefore, many disinfectants have a short action time, and after the action time, they will cause more serious infections

Method used

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  • A kind of gynecological disinfectant and preparation method thereof
  • A kind of gynecological disinfectant and preparation method thereof
  • A kind of gynecological disinfectant and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] One, vitamin C aqueous solution, 0.48% folic acid aqueous solution, 3.46% acetic acid-0.58% sodium acetate acetic acid-sodium acetate The buffer solution and the three combination solutions of the above concentrations were used for the antibacterial test (Escherichia coli). The results show that vitamin C aqueous solution and folic acid aqueous solution have weak antibacterial effects, acetic acid-sodium acetate buffer solution has certain antibacterial effects, and the combination of the three corresponding concentrations has good antibacterial effects, as shown in Table 1 below.

[0036] Table 1

[0037]

[0038] 2. Design the different ratios of vitamin C, folic acid, acetic acid and sodium acetate aqueous solution. Wherein the concentration of the first group is lower than the proportioning range of these components in the gynecological disinfectant of the present invention, the second, third and fourth groups are within the proportioning range, and the concentr...

Embodiment 2

[0050] (1) Accurately weigh 9.13g vitamin C, 1.03g vitamin E, 5.00g humectant (glycerol, polyethylene glycol-400, Tween-20 or Tween-40), slowly add to 60.00 g of purified water, and continued to stir for 15 minutes to obtain medicinal solution 1.

[0051] (2) Accurately weigh 0.58g of sodium acetate and 0.48g of folic acid, and slowly add them to 20.32g of purified water under stirring to obtain medicinal solution 2; then slowly add medicinal solution 2 to medicinal solution 1, and continue to stir for 5 minutes, Obtain liquid medicine 3.

[0052] (3) Accurately weigh 3.46g of acetic acid, slowly add it into the liquid medicine 3 under stirring, and continue to stir evenly to obtain a gynecological disinfectant.

[0053] Put the prepared disinfectant solution in an open room (25°C, humidity 40%) and let it stand, and measure the pH change and quality change after 24 hours. The results (Table 5) showed that compared with the pure water control group, the humectant group was s...

Embodiment 3

[0057] (1) Accurately weigh 9.13g of vitamin C, 1.03g of vitamin E, 5.00g of glycerol, and 5.00g of polyethylene glycol-400, slowly add them to 60.00g of purified water under stirring, and continue stirring for 15 minutes to obtain a medicinal solution 1.

[0058] (2) Accurately weigh 0.58g of sodium acetate and 0.48g of folic acid, and slowly add them to 15.32g of purified water under stirring to obtain medicinal solution 2; then slowly add medicinal solution 2 to medicinal solution 1, and continue to stir for 5 minutes, Obtain liquid medicine 3.

[0059] (3) Accurately weigh 3.46g of acetic acid, slowly add it into the liquid medicine 3 under stirring, and continue to stir evenly to obtain a gynecological disinfectant.

[0060] Get the gynecological antiseptic solution of this embodiment gained to detect by following index, each index is as follows:

[0061] (1) Appearance: Colorless or light yellow liquid with slight acetic acid smell.

[0062] (2) Physical and chemical ...

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Abstract

The invention discloses a gynecological disinfectant and a preparation method thereof, belonging to the field of medical disinfectant. The gynecological disinfectant of the present invention comprises the following components by mass percentage: glycerol 0%-5%, polyethylene glycol-400 0%-5%, Tween-20 0%-5%, Tween-200%-5%. Temperature-40 0%-5%, vitamin C 8%-10%, vitamin E 0%-2%, folic acid 0.4%-2%, acetate 0.5%-2%, acetic acid 2%-8%, balance for water. Add and mix these components in a certain order to obtain the gynecological disinfectant. The gynecological disinfectant has a broad-spectrum bactericidal effect on Staphylococcus aureus, Escherichia coli, and Candida albicans, which are common in gynecological vaginitis, and does not kill beneficial bacteria such as lactic acid bacteria. It can adjust and stabilize vaginal pH, and the action time is long. All ingredients are non-toxic, harmless and non-irritating, with mild action, very suitable as a compound disinfectant for safe and effective treatment of vaginitis.

Description

technical field [0001] The invention belongs to the field of medical disinfectant, in particular to a gynecological disinfectant and a preparation method thereof. Background technique [0002] The incidence of reproductive tract infection is high, and a safe and effective method for treating gynecological vaginitis is urgently needed. At present, the main skin and mucous membrane disinfectants are mainly ethanol, iodine and iodine preparations, chlorhexidine, quaternary ammonium compounds, triclosan, metronidazole antibiotics, etc. Among them, the ethanol solution with a concentration of 60-80% has the best bactericidal effect, but its persistence is poor and its bactericidal spectrum is narrow; iodine and iodine preparations have a good bactericidal effect, but they are easy to color on the skin, mucous membranes or clothing, causing the problem of difficult elution. It is usually used as a topical disinfectant. Chlorhexidine and quaternary ammonium compounds have a narro...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/519A61K31/19A61K31/375A61K31/355A61K9/08A61K47/10A61K47/26A61P15/02A61P31/04A61P31/10
CPCA61K9/0034A61K9/08A61K31/19A61K31/355A61K31/375A61K31/519A61K47/10A61K47/26A61P15/02A61P31/04A61P31/10A61K2300/00Y02A50/30
Inventor 李立家胡焰肖珂
Owner WUHAN UNIV
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