Fluorescent probe capable of detecting nerve poison in ratio multi-time visualization manner as well as preparation and application

Abstract

The invention discloses a fluorescent probe capable of detecting a nerve poison in a ratio mult-time visualization manner as well as preparation and application. The probe is a ratio type fluorescentprobe prepared from 7-diethylamino-4-methylcoumarin, N-bromosuccinimide and p-nitrobenzyl bromide as raw materials. The probe can realize high-sensitivity ratio fluorescence detection on diethyl chlorophosphate. Compared with an existing fluorescence detection technology, the obtained fluorescence probe has double-ratio detection and repeated use functions, is high in fluorescence, simple in synthetic route, simple and convenient in detection method and suitable for amplification synthesis and actual production application, and has huge application prospects in the technical fields of analytical chemistry, life science, environmental science and the like.

Description

technical field [0001] The invention belongs to the field of chemical material preparation and analysis and detection, and relates to the preparation and application of a fluorescent probe capable of ratiometrically detecting nerve agents, in particular, to a fluorescent probe capable of ratiometrically detecting nerve agents and its preparation and application . Background technique [0002] Since the 21st century, terrorist incidents have occurred frequently in the world, and organophosphorus nerve agents such as sarin, tabun, and soman are often used by terrorists as chemical weapons, so the detection of organophosphorus nerve agents is receiving more and more scientific research workers' attention. The characteristic of this type of nerve agent is that it can damage the body through skin, eye contact or inhalation through the respiratory tract, leading to dysfunction of the central nervous system, and even fatal in severe cases. Moreover, most of these poisons are colo...

AI Technical Summary

Problems solved by technology

So far, the research work of using colorimetric and fluorescent methods to detect nerve agent simulants has been reported in some literatures (Sensors and Actuators B: Chemical 2019, 298, 126923; Journal of Materials Chemistry C 2016, 4, 10105-10110; ACS Macro Lett, 2015, 4, 138—142), but most of these probes are either limited to detection in solution, or can no longer be used after one use, and a few materials that can realize two-phase detection usually have complex structures and cumbersome synthesis

Therefore, it is still difficult to design simple and efficient sensing materials for organophosphorus nerve agent simulants that can be used for both solution and gas phase detection and are reusable.

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