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Cancer genome Hi-C data simulation method and device and electronic equipment

A technology of data simulation and electronic equipment, applied in the field of genomics, can solve the problems of inability to support simulated chromosome inversion or continuous connection of multiple translocation chromosomes, inability to reflect the specific interaction characteristics of different genomic locations, and limited structural variation.

Active Publication Date: 2020-09-04
ACADEMY OF MILITARY MEDICAL SCI
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Problems solved by technology

[0004] At present, the Hi-C data of cancer genomes are generally simulated by the average decay curve based on the decrease of chromosome interaction frequency with the increase of genome distance, but this method cannot reflect the specific interaction characteristics of different genomic positions. At the same time, the simulated structure Mutation scenarios are limited and cannot support complex scenarios such as chromosomal inversion or continuous connection of multiple translocated chromosomes

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  • Cancer genome Hi-C data simulation method and device and electronic equipment
  • Cancer genome Hi-C data simulation method and device and electronic equipment
  • Cancer genome Hi-C data simulation method and device and electronic equipment

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[0054] In order to make the purposes, technical solutions and advantages of the embodiments of the present application clearer, the technical solutions in the embodiments of the present application will be clearly and completely described below in conjunction with the drawings in the embodiments of the present application. Obviously, the described embodiments It is a part of the embodiments of this application, not all of them. The components of the embodiments of the application generally described and illustrated in the figures herein may be arranged and designed in a variety of different configurations.

[0055] Accordingly, the following detailed description of the embodiments of the application provided in the accompanying drawings is not intended to limit the scope of the claimed application, but merely represents selected embodiments of the application. Based on the embodiments in this application, all other embodiments obtained by persons of ordinary skill in the art w...

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Abstract

The embodiment of the invention provides a cancer genome Hi-C data simulation method and device and electronic equipment, and relates to the technical field of genomics. According to the method, a specified variation mode can be adopted to simulate chromosome structure variation of a cancer genome and the interaction frequency matrix and the gene information of the reference enzyme digestion fragment are taken as templates; the simulated Hi-C data of the cancer genome is obtained in combination with the chromosome structure variation characteristics, various variation conditions of the chromosome are simulated, and the interaction characteristics of different positions of the cancer genome can be reflected, so that the accuracy of simulating the Hi-C data of the cancer genome is improved.

Description

technical field [0001] The present application relates to the technical field of genomics, in particular, to a cancer genome Hi-C data simulation method, device and electronic equipment. Background technique [0002] High-throughput chromosome conformation capture technology (High-throughput chromosome conformation capture, Hi-C) is the use of high-throughput sequencing technology, combined with bioinformatics analysis methods, to study the entire chromatin deoxyribose nucleic acid (DeoxyriboNucleic Acid, DNA) in the whole genome In relation to spatial position, construct chromosome-span haplotypes, capture spatial interaction information between different gene loci at the same time, obtain high-resolution chromatin three-dimensional structure information, and develop technology to regulate DNA elements of genes. [0003] The Hi-C sequencing data obtained based on the Hi-C technology represents the interaction frequency map between all enzyme-cut fragments, which can be conv...

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Application Information

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IPC IPC(8): G16B5/20G16B20/00
CPCG16B5/20G16B20/00
Inventor 陈河兵洪浩李昊江帅杜桂芳陶欢孙昱王军婷许康伯晓晨
Owner ACADEMY OF MILITARY MEDICAL SCI
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