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Auxiliary assessment method for prognosis of nasopharynx cancer based on enhanced MRI radiomics

A radiomics and nasopharyngeal cancer technology, applied in medical science, diagnosis, diagnostic recording/measurement, etc., can solve problems such as organ damage, large damage, hematopoietic function, reproductive system function, etc., to achieve clear display and ensure accuracy sexual effect

Active Publication Date: 2020-09-15
XIANGYA HOSPITAL CENT SOUTH UNIV
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Problems solved by technology

In the process of CT examination, a large amount of radioactive rays will be produced, mainly X-rays, and this kind of rays will cause certain harm to various organs, tissues and organs of the human body during the process of passing through the human body, mainly to the corresponding It will affect the hematopoietic function and reproductive system function. For patients who need long-term follow-up clinical observation, the use of CT imaging examination is extremely harmful.

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  • Auxiliary assessment method for prognosis of nasopharynx cancer based on enhanced MRI radiomics
  • Auxiliary assessment method for prognosis of nasopharynx cancer based on enhanced MRI radiomics
  • Auxiliary assessment method for prognosis of nasopharynx cancer based on enhanced MRI radiomics

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Embodiment Construction

[0024] Below in conjunction with embodiment the specific embodiment of the present invention is described in further detail:

[0025] Such as figure 1 and figure 2 As shown, an embodiment of an auxiliary assessment method for nasopharyngeal carcinoma prognosis based on enhanced MRI radiomics, comprising the following steps:

[0026] Step (1), MRI image processing: Delineate the tumor area on the enhanced MRI sequence of the nasopharynx in patients with nasopharyngeal carcinoma, including: 1), collect clinical, pathological characteristics and follow-up data of patients with stage III-IV nasopharyngeal carcinoma; 2 ), obtain the MRI images of the nasopharynx of the above patients, and randomly divide the patients into a training set and a verification set according to the ratio of 3:1; 3), use the software package Radiomics (based on the matlab platform) to analyze the enhanced MRI (contrast T1 weighted Phase, CE-T1W1) images were sorted out and target regions were segmented...

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Abstract

The invention relates to an auxiliary assessment method for prognosis of nasopharynx cancer based on enhanced MRI radiomics. The auxiliary assessment method comprises the steps of: (1), performing MRIimage processing; (2), extracting imaging features; (3), screening the imaging features; (4), establishing a radiomics scoring formula; (5), screening clinical risk factors; and (6), establishing a prognostic survival model: establishing a prognostic observation model through combination of a radiomics score and the clinical risk factors of a patient with nasopharynx cancer, performing qualitative and quantitative prediction on the PFS (progression free survival) of the patient, and furthermore, assessing the performance of the prognostic survival model. The auxiliary assessment method in theinvention has little harm to the image examination of the patient; qualitative and quantitative analysis on the survival time of a specific patient is carried out; therefore, a doctor is assisted tomake an individualized treatment and follow-up visit scheme; furthermore, the doctor is assisted to assess the survival and recurrence time of the patient; simultaneously, the performance of the obtained prognostic survival model is verified; and thus, the accuracy of a prognostic prediction model is ensured.

Description

technical field [0001] The invention relates to the technical field of nasopharyngeal carcinoma prognosis auxiliary assessment, in particular to a nasopharyngeal carcinoma prognosis auxiliary assessment method based on enhanced MRI radiomics. Background technique [0002] Nasopharyngeal carcinoma refers to malignant tumors that occur on the top and side walls of the nasopharyngeal cavity. It is one of the high-risk malignant tumors in my country, accounting for 78.08% of head and neck malignant tumors and 92.99% of upper respiratory tract cancers. The World Health Organization survey reported that 80% of nasopharyngeal cancer patients in the world are in China, and the number is higher in southern China, including Guangdong, Guangxi and Hunan. The pathology of nasopharyngeal carcinoma is mostly poorly differentiated squamous cell carcinoma, with high malignancy and hidden location, especially in the pharyngeal recess and the top of the nasopharynx. The early symptoms are not...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B5/055A61B5/00
CPCA61B5/055A61B5/7267A61B5/0033Y02A90/10
Inventor 刘勇卢善翃毛弈韬谭磊李果高妍邱元正黄东海张欣
Owner XIANGYA HOSPITAL CENT SOUTH UNIV
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