Unlock instant, AI-driven research and patent intelligence for your innovation.

Licorice extract and essential oil composite nanoemulsion preparation and preparation method

A technology of licorice extract and emulsion preparation, applied in directions such as drug combination, pharmaceutical formula, emulsion delivery, etc., to achieve the effects of mild preparation conditions, fresh breath, and guaranteeing biological safety

Pending Publication Date: 2020-09-18
煜宜(上海)健康管理有限公司 +1
View PDF3 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Licorice, honeysuckle, propolis, Platycodon grandiflorum, and Pueraria lobata root have been considered to have antibacterial and anti-inflammatory effects in the research of traditional Chinese medicine in my country, but there are no reports about their application in the treatment of oral diseases.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Licorice extract and essential oil composite nanoemulsion preparation and preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Embodiment 1: see figure 1 , the specific preparation steps of a composite nanoemulsion of licorice crude extract and essential oil are as follows:

[0020] S1. Accurately weigh 0.5g of licorice crude extract and 0.5g of essential oil, place them in a centrifuge tube, vortex for 5-10min, make the two fully mixed, and obtain a milky yellow oily liquid, which is the oil phase;

[0021] S2. Accurately weigh 5g of surfactant Tween 20 and 50g of deionized water, place them in an 80ml beaker, place the beaker on a magnetic stirrer, set the temperature to 25°C, adjust the speed to 500rpm, and stir for 30min to obtain The clarified aqueous solution is the external water phase;

[0022] S3. Then slowly add the oil phase drop by drop, and initially disperse the oil phase into the outer water phase until all the components are completely dispersed, and then prepare the suspension with high shear. The shear conditions are as follows: the rotation speed is 12000rpm, the time After...

Embodiment 2

[0024] Example 2: Preparation of a composite nanoemulsion of licorice crude extract and essential oil

[0025] S1. Accurately weigh 0.5 g of licorice crude extract and 0.75 g of essential oil, place them in a centrifuge tube, vortex for 5-10 min, and mix the two fully to obtain a milky yellow oily liquid, which is the oil phase;

[0026] S2. Accurately weigh 5g of surfactant Tween 20 and 50g of deionized water, place them in an 80ml beaker, place the beaker on a magnetic stirrer, set the temperature to 25°C, adjust the speed to 500rpm, and stir for 30min to obtain The clarified aqueous solution is the external water phase;

[0027] S3. Then slowly add the oil phase drop by drop, and initially disperse the oil phase into the outer water phase until all the components are completely dispersed, and then prepare the suspension with high shear. The shear conditions are as follows: the rotation speed is 12000rpm, the time After 5 minutes, a yellow opaque emulsion was obtained, whic...

Embodiment 3

[0029] Example 3: Preparation of a composite nanoemulsion of licorice crude extract and essential oil

[0030] S1. Accurately weigh 0.5g of licorice crude extract and 1.0g of essential oil, place them in a centrifuge tube, vortex for 5-10min, make the two fully mixed, and obtain a milky yellow oily liquid, which is the oil phase;

[0031] S2. Accurately weigh 5g of surfactant Tween 20 and 50g of deionized water, place them in an 80ml beaker, place the beaker on a magnetic stirrer, set the temperature to 25°C, adjust the speed to 500rpm, and stir for 30min to obtain The clarified aqueous solution is the external water phase;

[0032] S3. Then slowly add the oil phase drop by drop, and initially disperse the oil phase into the outer water phase until all the components are completely dispersed, and then prepare the suspension with high shear. The shear conditions are as follows: the rotation speed is 12000rpm, the time After 5 minutes, a yellow opaque emulsion was obtained, whi...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
particle sizeaaaaaaaaaa
dispersityaaaaaaaaaa
Login to View More

Abstract

The invention relates to a licorice extract and essential oil composite nanoemulsion preparation and a preparation method. The method comprises the following steps of S1, mixing a licorice crude extract with essential oil, carrying out stirring and heating at a rotating speed of 500-800 rpm at 20-35 DEG C for 1-6 h to obtain a cream-yellow oily liquid as an oil phase; S2, weighing a surfactant Tween 20 and deionized water at a mass ratio of 1:10 and then carrying out thorough mixing at a rotating speed of 500-800 rpm at room temperature to obtain a clear water solution as an external water phase; S3, dropwise dispersing the oil phase into the water phase until the oil phase is completely dispersed, and then carrying out high shearing to obtain a yellow opaque emulsion as a licorice crude elusion; and S4, carrying out high-pressure homogenization on the crude emulsion to obtain a translucent emulsion as a licorice and essential oil oil-in-water nanoemulsion.

Description

technical field [0001] The invention relates to a nanoemulsion preparation, in particular to a licorice extract and essential oil composite nanoemulsion preparation and a preparation method, belonging to the technical field of functional food additives. Background technique [0002] Caries is a common and frequently-occurring disease of the human oral cavity. The World Health Organization has listed caries as one of the three major non-communicable diseases for human beings to prevent and control. Streptococcus mutans is one of the resident bacteria in the oral cavity, and it is also the main pathogenic bacteria of dental caries. Fluoride has been used in the prevention and treatment of dental caries for more than 60 years. It is currently the most commonly used preparation for dental caries prevention. Its effectiveness in caries prevention has long been recognized and widely accepted. On the other hand, the use of fluoride also shows more and more obvious limitations, suc...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/752A61K9/107A61K47/26A61P1/02
CPCA61K9/1075A61K36/484A61K36/53A61K36/534A61K36/752A61K47/26A61P1/02A61K2300/00
Inventor 梁浩陈姗张丹煜孙志龙
Owner 煜宜(上海)健康管理有限公司