Composite drug carried system with multiple temperature responsiveness, and preparation method and application thereof

Abstract

The invention discloses a composite drug carried system with multiple temperature responsiveness, and a preparation method and an application thereof, and relates to a composite nanofiber stent drug carried system for controlled release of a variety of drugs. According to the invention, the composite drug carried system with multiple temperature responsiveness is prepared through a double-needle electrostatic spinning technology and serves as a drug delivery system for treatment of the focus of a human body. The system is composed of two components with different temperature stimulus responsiveness; drugs needing to be compositely used can be loaded in the two components of the system according to the purpose of treatment; the drugs in the different components are adjusted by changing thetemperature of the system to be differentially controlled and released; and the system can be suitable for scenes needing a plurality of drug use requirements and can achieve a better treatment effecton the focus of the human body. Meanwhile, the invention also discloses a two-component composite drug carried system carrying curcumin and ketoconazole. The two-component composite drug carried system is used as a wound dressing for repairing fungal infection, promotes wound healing and is applicable to popularization and application.

Description

Technical field [0001] The invention belongs to the field of composite nanofiber stent drug-carrying systems, and specifically relates to a composite nanofiber stent drug-carrying system that controls the release of multiple drugs, and specifically discloses a composite drug-carrying system with multiple temperature responsiveness and preparation thereof Methods and applications. Background technique [0002] The drug delivery system is a system that can use suitable carrier materials to combine with the drug according to the physical and chemical properties of the drug to be delivered, and deliver it to a specific lesion location in the human body, and effectively control the release of the drug for treatment. Compared with traditional drug delivery methods, a drug delivery system with controlled release of drugs can significantly improve the solubility and stability of the drug, and it can also effectively control the release rate of the drug, improve the utilization rate of th...

AI Technical Summary

Problems solved by technology

However, such a drug delivery system will undergo burst release at the initial stage of drug release, and two drugs with greatly different water solubility cannot be loaded in the nanofibers of the same matrix, which will limit some special biomedical applications.

Images