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Traditional Chinese medicine monomer for treating early endometriosis and application thereof

A technology for endometriosis and ectopic diseases, applied to medical preparations containing active ingredients, drug combinations, pharmaceutical formulas, etc.

Pending Publication Date: 2020-09-22
YUEYANG INTEGRATED TRADITIONAL CHINESE & WESTERN MEDICINE HOSPITAL SHANGHAI UNIV OF CHINESE TRADITIONAL MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Other studies on the drug's treatment of endometriosis have not been reported

Method used

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  • Traditional Chinese medicine monomer for treating early endometriosis and application thereof
  • Traditional Chinese medicine monomer for treating early endometriosis and application thereof
  • Traditional Chinese medicine monomer for treating early endometriosis and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] Embodiment 1 Chinese medicine granules

[0053] The preparation method is as follows:

[0054] Take traditional Chinese medicine monomer ginsenoside Rg3 and granule auxiliary agent, and prepare according to the conventional preparation method of granule.

Embodiment 2

[0055] Embodiment 2 Chinese medicine capsule

[0056] The preparation method is as follows:

[0057] Take traditional Chinese medicine monomer ginsenoside Rg3 and capsule auxiliary agent, and prepare according to the conventional preparation method of capsule.

Embodiment 3

[0058] The therapeutic effect of embodiment 3 ginsenoside Rg3 on endometriosis rats

[0059] 1.1 Experimental materials

[0060] 1.1.1 Experimental animals

[0061] Healthy adult (6-7 weeks old) SPF grade female Sprague-Dawley (SD) rats (180-200g) were purchased from Shanghai Xipuer-Bikay Laboratory Animal Co., Ltd., license number: SCXK (Shanghai) 2013-0016 , certificate number: 0022017.

[0062] 1.1.2 Reagents and equipment

[0063] 1.1.2.1 Drugs:

[0064] (1) Ginsenoside Rg3 was purchased from Shanghai Shengzhong Pharmaceutical Chemical Co., Ltd.; batch number 140321; content ≥ 95%; white powder.

[0065] (2) Gestrinone was purchased from Beijing Zizhu Pharmaceutical Co., Ltd.; batch number 06001011002; content 99.9%; white powder.

[0066] 1.2 Experimental method

[0067] 1.2.1 Feeding and estrous cycle monitoring of female SD rats:

[0068] Adult female SD rats were kept in the SPF-level rodent experimental animal room of Shanghai Institute of Family Planning Scien...

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Abstract

The invention relates to a traditional Chinese medicine monomer for treating early endometriosis and application thereof. The traditional Chinese medicine monomer is ginsenoside Rg3. Results show thatthe ginsenoside Rg3 can inhibit angiogenesis of ectopic endometrium of an endometriosis rat, but does not affect the form of the endometrium in situ, which indicates that physiological blood vesselsare not affected by the ginsenoside Rg3, so that the ginsenoside Rg3 has extremely low toxicity to normal tissues. Therefore, the ginsenoside Rg3 can be applied to early treatment of endometriosis andtreatment of residual lesions in laparoscopic surgery to prevent relapse without hindering ovulation, and conforms to ideal drugs for early treatment and prevention of endometriosis. In addition, ginsenoside Rg3 can obviously lower the level of serum E2 of rats suffering from endometriosis, but has no obvious influence on the serum P level, so that the ginsenoside Rg3 is prompted to adjust the in-vivo endocrine environment by adjusting the in-vivo hormone level, does not affect pregnancy while treatment diseases, is the most effective treatment for EMs, and is high in practicability.

Description

technical field [0001] The invention relates to the technical field of application of traditional Chinese medicine monomers, in particular to a traditional Chinese medicine monomer for treating early endometriosis and its application. Background technique [0002] Endometriosis (endometriosis, EMs) is a common and intractable disease in gynecology. It is characterized by persistent pelvic pain and infertility caused by the growth of endometrium outside the uterine cavity. lesion. The most typical symptom of this disease is secondary and progressive pain in the lower abdomen and lumbosacral region, which usually occurs 1 to 2 days before menstruation, and is the worst on the first day after menstruation. Disappears during menstruation. The etiology and pathogenesis of endometriosis are complex and changeable, and complications such as pain, infertility, and ovarian cancer risk seriously affect women's quality of life. The clinical etiology and pathogenesis of endometriosis...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/704A61P15/00A61P15/08A61K36/258
CPCA61K31/704A61P15/00A61P15/08A61K36/258
Inventor 曹阳张婷婷朱焰庄梦斐崔金刚张瑜杜尘王馨悦王唯迪
Owner YUEYANG INTEGRATED TRADITIONAL CHINESE & WESTERN MEDICINE HOSPITAL SHANGHAI UNIV OF CHINESE TRADITIONAL MEDICINE
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