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Method of purifying 6-gingerol

A technology of gingerol and ginger oleoresin, which is applied in the field of purification, can solve the problems of severe product dilution, low operation repeatability, and unsuitability for industrial production, and achieve stable operation and low solvent consumption

Active Publication Date: 2020-09-22
JOPE TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the existing separation and purification methods can only achieve enrichment of 6-gingerol content in ginger oleoresin, and cannot provide high-purity 6-gingerol
In addition, the existing separation and purification methods are all batch-operated purification methods, which often lead to serious dilution of the product in the actual production process, low operation repeatability, poor stability, and are not suitable for industrial production.

Method used

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  • Method of purifying 6-gingerol
  • Method of purifying 6-gingerol
  • Method of purifying 6-gingerol

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0068] [Single string test]

[0069] In order to set the operating conditions of simulated moving bed chromatography, before the actual separation of 6-gingerol, a suitable supercritical fluid chromatography system was screened out, and the retention behavior of 6-gingerol and other major impurities was investigated. In Experimental Example 1, ginger oleoresin was used as an analysis sample, and analyzed by the above analysis method using a high performance liquid chromatography ultraviolet detector (HPLC / UV). The stationary phase is random silica, and the mobile phase is supercritical carbon dioxide washing agent with isopropanol as auxiliary solvent. Among them, random silica as a stationary phase is filled in a packed column of 1 cm ID × 25 cm L, and supercritical fluid equipment is connected in series. The operation condition of supercritical fluid equipment is set as pressure 150bar, and temperature is 50 ℃, and carbon dioxide flow rate is set as 4.0 g / min, isopropanol f...

experiment example 2

[0092] [Single string test]

[0093] In the single-column test of Experimental Example 2, ginger oleoresin was used as an analysis sample, and analyzed by the above analysis method using a high performance liquid chromatography ultraviolet detector (HPLC / UV). The stationary phase is a preparative-grade surface-modified silica filler, and the mobile phase is a supercritical carbon dioxide flushing agent with isopropanol as an auxiliary solvent. Among them, the preparative-grade surface-modified silica filler used as the stationary phase is filled in a 1cm ID×25cm L packed column and then connected in series with supercritical fluid equipment. The operation condition of supercritical fluid equipment is set as pressure 140bar, 50 ℃ of temperature, carbon dioxide flow rate is set as 4.0 g / min, isopropanol flow rate is 0.898 milliliter / min (mass percentage is about 15wt%), under this condition super critical fluid density ρ SF = 0.724 g / mL.

[0094] Figure 6 Chromatograms obta...

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Abstract

The present invention provides a method of purifying 6-gingerol comprising providing a ginger oleoresin, where the ginger oleoresin comprises a 6-gingerol component and a mixed component. Then, 6-gingerol components in the ginger oleoresin are separated by adopting a simulated moving bed chromatography method; by applying the simulated moving bed chromatography, the 6-gingerol component and the mixed component in the ginger oleoresin can be separated so as to produce high-purity 6-gingerol.

Description

technical field [0001] The invention relates to a purification method, in particular to a method for purifying 6-gingerol. Background technique [0002] Ginger oleoresin is a dark brown viscous liquid extracted from ginger, and its main components are volatile oil and gingerol. Gingerol is a mixture of ingredients including gingerol, shogaol, gingerone, etc., and the ingredient with the highest content is gingerol. Gingerol has the effects of invigorating the stomach and anti-gastric ulcer, protecting the liver and gallbladder, anti-inflammatory, lowering blood fat, anti-arteriosclerosis, anti-oxidation and protecting myocardial cells. Among gingerols, 6-gingerol has the highest content. [0003] At present, the methods for separating and purifying 6-gingerol from ginger oleoresin mainly adopt solvent extraction, preparative column chromatography or preparative thin-plate chromatography, and crystallization for separation. Many studies have been conducted on the stationar...

Claims

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Application Information

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IPC IPC(8): C07C45/79C07C49/255
CPCC07C45/79C07C49/255Y02P20/54
Inventor 梁明在林智雄梁茹茜
Owner JOPE TECH CO LTD
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