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Detection method

An inspection method, a technology of organs, applied in the direction of measuring devices, fluorescence/phosphorescence, instruments, etc.

Pending Publication Date: 2020-09-22
MIE UNIVERSITY
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, there are few effective methods for identifying cancer cells and normal cells from the serosal surface or lumen of the digestive tract before and during surgery, and there is a strong demand for the development of this method

Method used

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Embodiment Construction

[0177] Next, embodiments of the present invention will be described with reference to the diagrams. However, the technical scope of the present invention is not limited to the following embodiments, and can be implemented in various forms without changing the gist of the present invention.

[0178] Examples of the cell staining agent used in the present invention include vital staining agents containing one or more edible coloring compounds. Pigment compounds include coal tar-based pigments (red No. 3 (erythrosine), red No. 104 (fluorescent pink), red No. 105, red No. 106, green No. 3 (fast green FCF), red No. 2, red No. 102 , Cyan No. 2 (Indigo Carmine), Yellow No. 4 (Lemon Yellow), Yellow No. 5 (Sunset Yellow FCF), etc.), iridoid pigments (High melon P-2 (Gardenia Blue: Gardenoside) , High Blue AT (gardenia blue pigment: geniposide), etc.), carotenoid pigments (High melon P-2 (yellow pigment: crocin), annatto (annatto N2R25, annatto fruit: carmin, Norbiretin), High melon P...

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Abstract

Provided is a vital stain inspection method for distinguishing between cancer cells and normal cells within a lumen, or on the serous membrane side of an organ, by means of laser irradiation after organ tissue has been stained by curcumin, Red No. 3 or Red No. 106, which are edible color dyes.

Description

technical field [0001] The invention relates to a living body dyeing inspection method and a tissue visualization method. After living body dyeing of organ tissues with edible pigment staining agents, cancer cells and normal cells in the organs are identified by laser irradiation. Background technique [0002] Today, cancer ranks first among the causes of death in Japan, with one in two Japanese residents suffering from cancer and one in four dying of cancer. Furthermore, the number of deaths from cancer is still increasing, and it is the desire of the people to reduce the number of deaths from cancer. The basic method to reduce the number of cancer deaths is the early detection of cancer, but the current endoscopic examination has the limitation that it is difficult to find malignant tumors with a diameter of less than 10-20 mm. Therefore, the mainstream treatment method for most cancer patients today is surgical resection of malignant tumors, and it is urgent to develop p...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B1/00G01N21/64
CPCA61K49/006A61B1/043A61B1/00172A61B1/00006A61B1/045G01N2021/6439G01N21/6458A61B1/000094A61B1/00055A61B1/063A61B1/31G01N21/6486A61B5/0071
Inventor 溝口明田中光司木村一志野阪哲哉田中匡介王淑杰垣内愛加崔煌植問山裕二後藤英仁杦本昌彦西村有平
Owner MIE UNIVERSITY