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Vancomycin-loaded hydroxyapatite mesoporous bioglass composite material, preparation method and application

A hydroxyapatite and nano-hydroxyapatite technology, used in tissue regeneration, medical science, prosthesis, etc., can solve the problems that implants do not have the ability to promote bone repair, produce sudden release effects, and have unstable overall release. , to achieve good biocompatibility, promote bone repair, and solve the effect of burst release effect

Pending Publication Date: 2020-10-16
SHANGHAI CHANGHAI HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] In view of the above-mentioned technical problems, the mesoporous bioglass composite material, preparation method and application of vancomycin-loaded hydroxyapatite provided by the present invention solve the problem that the bone cement mixed with vancomycin in the prior art will produce sudden release effect, unstable overall release, and the fact that the implant itself does not have the effect of promoting bone repair

Method used

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  • Vancomycin-loaded hydroxyapatite mesoporous bioglass composite material, preparation method and application
  • Vancomycin-loaded hydroxyapatite mesoporous bioglass composite material, preparation method and application
  • Vancomycin-loaded hydroxyapatite mesoporous bioglass composite material, preparation method and application

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Embodiment 1

[0050] In the prior art, for the treatment of bone infection, clinical orthopedists often use the method of mixing vancomycin with bone cement to release vancomycin locally to treat bone infection. However, this local treatment method has the following problems: (1) burst release effect; (2) unstable overall release; (3) the implant itself does not have the effect of promoting bone repair.

[0051] In order to solve the problems in the prior art that the method of bone cement mixed with vancomycin will produce a burst release effect, the overall release is unstable, and the implant itself does not have the effect of promoting bone repair, the embodiment 1 of the present invention provides a A mesoporous bioglass composite of vancomycin-loaded hydroxyapatite, such as figure 1 As shown, the composite material uses nano-hydroxyapatite material A as a carrier; nano-hydroxyapatite material A is coated with mesoporous bio-glass sol material a, and mesoporous bio-glass sol material (...

Embodiment 2

[0054] The preparation method of the mesoporous bioglass composite material of a kind of vancomycin-loaded hydroxyapatite provided in this embodiment, such as figure 2 shown, including the following steps:

[0055] Dispersion system preparation steps: prepare mesoporous bioglass sol, the composition of mesoporous bioglass sol is: CaO-P 2 o 5 -SiO 2 , wherein, Ca:Si:P molar ratio is 80:15:5; Prepare vancomycin solution, the concentration of vancomycin solution is 5mg / mL;

[0056] Coating treatment steps: using nano-hydroxyapatite as the main body of the material, placing the main body of the nano-hydroxyapatite material in the prepared mesoporous bioglass sol, so that the surface of the main body of the nano-hydroxyapatite material is coated with Mesoporous bioglass sol to obtain nano-hydroxyapatite mesoporous bioglass composite material;

[0057] Further, the coating treatment steps are as follows: use nano-hydroxyapatite as the main body of the material; preheat the wate...

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Abstract

The invention relates to the field of medical materials, in particular to a vancomycin-loaded hydroxyapatite mesoporous bioglass composite material. The composite material takes a nano hydroxyapatitematerial as a carrier; the nano hydroxyapatite material is coated with a mesoporous bioglass sol material; pores of the mesoporous bioglass sol material is loaded with vancomycin. The composite material has better effects of promoting bone repair and resisting infection. On the one hand, the mesoporous bioglass component of the composite material can achieve stabilization and long-acting slow release of loaded antibiotics, so that bone repair is promoted; and on the other hand, by introduction of vancomycin, the composite material has anti-infection effect. Therefore, the problems that suddenrelease effect can be generated, the overall release is unstable and an implant does not have the function of promoting bone repair of the bone cement and vancomycin mixing method in the prior art aresolved.

Description

technical field [0001] The invention relates to the technical field of medical materials, in particular to a mesoporous biological glass composite material of hydroxyapatite loaded with vancomycin, a preparation method and an application. Background technique [0002] Chronic osteomyelitis has always been a difficult problem for clinical orthopedics. In the prior art, the clinical treatment of chronic osteomyelitis mainly adopts the method of intravenous infusion of sensitive antibiotics (because the most common pathogenic bacteria of osteomyelitis is Staphylococcus aureus , so the most commonly used antibiotic is vancomycin). [0003] However, for chronic osteomyelitis with bone defects (also known as infectious bone defects), the etiology is mostly caused by severe open trauma, often accompanied by severe soft tissue injuries, resulting in bone defects, bone infection sites The blood supply is poor, and the antibiotics given by intravenous infusion often cannot reach the ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/10A61L27/12A61L27/50A61L27/54A61L27/56
CPCA61L27/12A61L27/10A61L27/54A61L27/50A61L27/56A61L2430/02A61L2300/406
Inventor 许硕贵王国成夏琰徐正江李璐周潘宇章云童
Owner SHANGHAI CHANGHAI HOSPITAL
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