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Application of atractylenolide II in preparation of anti-renal fibrosis drug and anti-renal fibrosis drug

A technique for renal fibrosis and atractylide, which is applied in the field of medicine, can solve the problems of difficult recurrence, incomplete treatment, and large side effects of anti-renal fibrosis drugs.

Active Publication Date: 2020-10-23
ZHEJIANG CHINESE MEDICAL UNIVERSITY
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In order to solve the problems of large side effects and incomplete treatment of anti-renal fibrosis drugs in the prior art, the present invention provides an application of Atractylodes lactone II in the preparation of anti-renal fibrosis drugs, and the anti-renal fibrosis effect of Atractylodes lactone II Significant and difficult to relapse after treatment

Method used

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  • Application of atractylenolide II in preparation of anti-renal fibrosis drug and anti-renal fibrosis drug
  • Application of atractylenolide II in preparation of anti-renal fibrosis drug and anti-renal fibrosis drug
  • Application of atractylenolide II in preparation of anti-renal fibrosis drug and anti-renal fibrosis drug

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Experimental program
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Effect test

Embodiment 1

[0031] Select 24 healthy SD male rats with a body weight of 190-210 g (purchased from Shanghai Slack Experimental Animal Co., Ltd.), and randomly divide them into a sham operation group, a 5 / 6 nephrectomy group, and atractyloid Ⅱ treatment group (with physiological Atractylactone II was configured in saline to form a 2 mg / kg suspension of Atractyloid II).

[0032] Preparation of 5 / 6 nephrectomy rat model: make a 5 / 6 nephrectomy rat model according to the standard two-step method, anesthetize with 10% chloral hydrate (400mg / kg) intraperitoneal injection, fix the rat prone in the operation On the stage, the local skin was clipped, and the outer side of the right subcostal rectus was routinely disinfected. Under aseptic operation, all layers of the right dorsal skin were cut to expose the right kidney, and the renal pedicle was ligated. The gelatin sponge was pressed to stop the bleeding. After the bleeding stopped, it was sutured and bandaged. The resected right kidney accounted...

Embodiment 2

[0037] The UUO-induced renal fibrosis model in mice was prepared by ligation of the left ureter. Unilateral ureteral obstruction (UUO) is a classic animal model for the study of renal fibrosis. UUO can directly lead to tubulointerstitial fibrosis (TIF). Its features are similar to those of human fibrosis.

[0038] 30 mice were selected and randomly divided into sham operation group, mouse unilateral ureteral obstruction model group (UUO group) and atractyloid Ⅱ group, with 10 mice in each group.

[0039] The mice in the model group and the atractyloid Ⅱ group were subjected to left ureteral ligation to form a model of renal fibrosis. The mice in the sham operation group did not ligate the left ureter.

[0040] Each administration group began administration on the day of modeling, and the sham operation group and the model group were intragastrically administered equal volumes of normal saline, and the experiment lasted for 7 days.

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Abstract

The invention relates to the field of medicines, and provides an application of atractylenolide II in preparation of an anti-renal fibrosis medicine, and an effective anti-renal fibrosis effect can beachieved by taking an atractylenolide II monomer as an effective component. The invention further provides an anti-renal fibrosis medicine which comprises the atractylenolide II and pharmaceutic adjuvants. Researches show that the atractylenolide II has a good effect of treating renal fibrosis.

Description

technical field [0001] The invention relates to the field of medicines, in particular to the application of atractylactone II in the preparation of anti-renal fibrosis drugs and the anti-renal fibrosis drugs containing atractylodes lactone II. Background technique [0002] Renal fibrosis is a typical multifactorial and complex disease. Current treatment measures mainly include the use of angiotensin-converting enzyme inhibitors, angiotensin receptor antagonists, and gene therapy. The treatment plan provided by the prior art has the advantages of anti-inflammation, anti-coagulation and rapid onset of action, but it can only target a single cause and cannot achieve the purpose of comprehensive treatment. With the continuous deepening of human understanding of the nature of diseases and the development of modern medicine, the modern medical community has gradually realized that complex diseases caused by multiple genes and multiple environmental factors, it is difficult to obta...

Claims

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Application Information

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IPC IPC(8): A61K31/365A61P13/12
CPCA61K31/365A61P13/12
Inventor 曹岗
Owner ZHEJIANG CHINESE MEDICAL UNIVERSITY
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