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The invention also discloses application of glycolysis inhibitor in preparation of medicines for preventing and treating porcine reproductive and respiratory syndrome virus infection

A technology for respiratory syndrome and viral infection, applied in medicine, in the field of glycolysis inhibitors, can solve problems such as virus drug resistance mutation, in-depth research on anti-virus effect of pigs, and drug failure

Active Publication Date: 2020-10-23
NANJING AGRICULTURAL UNIVERSITY
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Problems solved by technology

However, the research on the antiviral mechanism of these drugs and their antiviral effects in pigs is not yet in-depth, and because PRRSV is prone to mutation, antiviral drugs against PRRSV are likely to cause drug-resistant mutations in the virus, thereby making the drug ineffective

Method used

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  • The invention also discloses application of glycolysis inhibitor in preparation of medicines for preventing and treating porcine reproductive and respiratory syndrome virus infection
  • The invention also discloses application of glycolysis inhibitor in preparation of medicines for preventing and treating porcine reproductive and respiratory syndrome virus infection
  • The invention also discloses application of glycolysis inhibitor in preparation of medicines for preventing and treating porcine reproductive and respiratory syndrome virus infection

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Embodiment Construction

[0025] Below in conjunction with specific embodiment, further illustrate the present invention.

[0026] 1. Materials and methods

[0027] 1.1 Cells and viruses

[0028] Highly pathogenic PRRSV strain BB0907 and Marc-145 cells are preserved by the laboratory and are conventional strains and cells that have been disclosed in the prior art.

[0029] 1.2 Main reagents

[0030] Sodium oxamate (Sodium oxamate) was purchased from Nanjing Jinyibai Biotechnology Co., Ltd., with a purity of >98%; 2-deoxy-D-glucose (2-DG) was purchased from Sigma; Galloflavin) was purchased from APExBIO; the enhanced CCK8 kit was purchased from Beyond Biotechnology Co., Ltd.; the anti-PRRSV N protein antibody (2H7) was prepared and preserved by a graduate student in our laboratory; the labeled Alex 594 goat anti-mouse fluorescent secondary antibody was purchased from Beyond Biotech Ltd; Reverse Transcriptase HiScript II 1st Strand cDNA Synthesis Kit and qPCR Green MasterMix was purchased from Nan...

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Abstract

The invention discloses application of a glycolysis inhibitor in preparation of a medicine for preventing and treating porcine reproductive and respiratory syndrome virus infection. Researches find that the glycolysis inhibitor can be used for preventing and treating porcine reproductive and respiratory syndrome virus infection; particularly, the replication of the PRRSV in a pig body can be remarkably inhibited by orally taking a lactic dehydrogenase inhibitor, namely sodium oxalyl or pedioxanthin; the new application of the glycolysis inhibitor, especially the lactic dehydrogenase inhibitor(sodium oxalyl or peptin), as the PRRSV antagonist is discovered for the first time, and the anti-PRRSV drug effect of the glycolysis inhibitor is clear in component, controllable in quality, safe andnon-toxic, so that the glycolysis inhibitor has a good application prospect in the aspect of preventing and treating porcine reproductive and respiratory syndrome.

Description

technical field [0001] The invention belongs to the technical field of veterinary prevention and treatment drugs, and in particular relates to the application of glycolysis inhibitors in the preparation of drugs for prevention and treatment of porcine reproductive and respiratory syndrome virus infection. Background technique [0002] The pathogen of porcine reproductive and respiratory syndrome is porcine reproductive and respiratory syndrome virus (porcine reproductive and respiratory syndrome virus, PRRSV), which belongs to Arteriviridae and is a single-stranded positive-sense RNA virus. The virus infection can cause reproductive disorders in pregnant sows, respiratory system disorders in pigs of all ages, immunosuppression in pigs, and diseases that promote secondary infections, causing huge economic losses to the pig breeding industry at home and abroad. Commercial vaccines are not yet ideal. The cross-protection ability of the vaccine against the virus strains is not ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/00A61K31/7004A61K31/198A61K31/366A61P31/14
CPCA61K45/00A61K31/7004A61K31/198A61K31/366A61P31/14A61K2300/00
Inventor 姜平刘雪威白娟王先炜
Owner NANJING AGRICULTURAL UNIVERSITY
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