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Transdermal patch containing diclofenac epolamine and preparation method of transdermal patch

A technology of diclofenac epoamide and transdermal patch is applied to the transdermal patch containing diclofenac epoamide and the field of preparation thereof, and can solve the problems of low drug utilization rate, low drug permeability of the transdermal patch and the like

Inactive Publication Date: 2020-10-27
NANJING HEALTHNICE MEDICAL TECH +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the transdermal patch disclosed in this patent has low drug permeability, resulting in low drug utilization

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Mix 1% eporamide diclofenac, 5% laurocaprolactone, 5% limonene and 89% gel matrix to make a drug-loaded gel, and apply the drug-loaded gel to the release layer The thickness of the gel layer after drying is about 80 μm, and the drug-loaded gel layer is formed after drying at 70° C., the surface of the drug-loaded gel layer is covered with an anti-adhesive layer, and cut into patches.

Embodiment 2

[0036] Diclofenac eporamide 2%, laurocaprolactone 3%, limonene 8% and 87% gel matrix are mixed uniformly to make drug-loaded gel, and this drug-loaded gel is coated on the release layer, so that After drying, the thickness of the gel layer is about 80 μm. After drying at 75° C., a drug-loaded gel layer is formed. The surface of the drug-loaded gel layer is covered with an anti-adhesive layer and cut into patches.

Embodiment 3

[0038] Mix 3% eporamide diclofenac, 2% laurocaprolactone, 8% limonene and 87% gel matrix to make a drug-loaded gel, and apply the drug-loaded gel to the release layer The thickness of the gel layer after drying is about 80 μm, and the drug-loaded gel layer is formed after drying at 80° C., the surface of the drug-loaded gel layer is covered with an anti-adhesive layer, and cut into patches.

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PUM

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Abstract

The invention relates to a transdermal patch containing diclofenac epolamine and a preparation method of the transdermal patch. The transdermal patch comprises a back lining layer and a medicine carrying gel layer coated to the surface of the back lining layer, wherein the medicine carrying gel layer consists of active components of the diclofenac epolamine, a penetrating agent and gel made from agel substrate; and the penetrating agent consists of laurocapram and limonene. The laurocapram and the limonene are used as the penetrating agent to prepare the transdermal patch containing diclofenac epolamine, and the transdermal patch containing diclofenac epolamine is used for relieving pain of muscle, parenchyma and joints, and has excellent osmotic effects.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, in particular to a transdermal patch containing diclofenac eporamide and a preparation method thereof. Background technique [0002] Transdermal patch refers to a thin-skinned preparation that can be attached to the skin, and the percutaneous absorption of the drug will produce systemic or local therapeutic effects. The advantage of transdermal preparations is that there is no liver first-pass effect, and it is not affected by the gastric emptying rate. High bioavailability, easy to use, no pain, can withdraw or interrupt treatment at any time, accurate dosage, fixed absorption area, stable blood drug concentration, no rosin and other thickeners, less irritation to the skin, prolong the action time, reduce Therefore, it has been widely studied and applied in the field of pharmaceutical preparations in recent years. [0003] Diclofenac eporamide is a powerful non-steroidal anti-inflamma...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61K31/196A61K31/40A61K47/22A61K47/06A61K47/42A61K47/12A61K47/10A61K47/32A61P29/00
CPCA61K9/7023A61K31/196A61K31/40A61K47/06A61K47/10A61K47/12A61K47/22A61K47/32A61K47/42A61P29/00
Inventor 徐丽殷坤郭金花王华娟
Owner NANJING HEALTHNICE MEDICAL TECH
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