Phosphorylcholine group-containing polysiloxane monomer

A technology of polysiloxane monomer and acylcholine, which is applied in instruments, glasses/goggles, optics, etc., to achieve the effects of suitable mechanical strength, surface hydrophilicity and suitable oxygen permeability

Active Publication Date: 2020-11-06
NOF CORP
View PDF12 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since it has both phosphorylcholine and amino groups, it cannot be said to be absolutely safe

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Phosphorylcholine group-containing polysiloxane monomer
  • Phosphorylcholine group-containing polysiloxane monomer
  • Phosphorylcholine group-containing polysiloxane monomer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0147] The analysis condition of embodiment 1

[0148] The analysis conditions of Example 1 are as follows.

[0149] 1 H NMR assay

[0150] Measuring device: JNM-AL400 manufactured by JEOL Ltd.

[0151] Solvent: CDCl 3 (TMS Benchmark)

Embodiment 2

[0152] Components used in Example 2 and Comparative Example

[0153] Components other than the polysiloxane monomer of the present invention used in Example 2 and Comparative Example are as follows.

[0154] 〇Comparative compound of formula (1)

[0155] PMPC: a macromonomer containing a phosphorylcholine functional group side chain (the compound of Experimental Example 4 of Patent Document 8)

[0156] FM-7721: JNC Corporation, two-terminal methacryloxy polydimethylsiloxane (molecular weight ≒ 5,000)

[0157] 〇Other monomers

[0158] SiGMA: 2-Hydroxy-3-(tris(trimethylsilyloxy)silyl)propyl methacrylate ES: 4-(2-hydroxyethyl)=1-[3-tris(trimethyl) silyloxy) silyl propyl] = 2-methine succinate

[0159] TEGDMA: Tetraethylene glycol dimethacrylate

[0160] 〇Hydrophilic monomer

[0161] MPC: 2-(methacryloyloxyethyl)-2-(trimethylaminoethyl)phosphate

[0162] HPMA: Hydroxypropyl methacrylate (a mixture of 2-hydroxypropyl and 2-hydroxy-1-methylethyl ester, manufactured by NIPPONSH...

Embodiment 1-1

[0178] In a 100 mL three-necked flask, make 10.00 g of silicone intermediate 1 (hydrosilyl group-containing two-terminal methacryloyl silicone represented by formula (4)) and 0.2140 g of alkene-containing silicone represented by formula (5) The propyl phosphorylcholine compound was dissolved in 10.00 g of 2-propanol, heated to 80° C. using an oil bath, and then 40 μL of a 4% by weight hexachloroplatinic acid hexahydrate 2-propanol solution was added.

[0179] Dissolve 1.93 g of the allyl group-containing phosphorylcholine compound represented by the formula (5) in a solution of 5.78 g of 2-propanol to obtain a solution, add the solution to a 10 mL dropping funnel, and install In the upper part of the three-neck flask.

[0180] The solution in the dropping funnel was dropped over 30 minutes while maintaining 80°C. After the dropwise addition, the reaction was further carried out in a reflux state for 1 hour. After removing low-boiling point components by vacuum distillation, ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

Provided is a monomer which is suitable for application to an ophthalmic device and has a high surface hydrophilicity, a high oxygen permeability, and an appropriate mechanical strength when copolymerized with a polymerizable monomer such as a hydrophilic monomer. The present invention was completed upon confirming that the phosphorylcholine group-containing polysiloxane monomer can solve the problem.

Description

technical field [0001] The present invention relates to a polymerizable phosphorylcholine group-containing polysiloxane monomer, which can be used in the manufacture of ophthalmic devices, such as contact lenses, intraocular lenses, artificial cornea. [0002] This application claims the priority of Japanese Application Japanese Patent Application No. 2018-073052 which is incorporated by reference into this application. Background technique [0003] Silicone hydrogel is a material widely used in ophthalmic lenses such as contact lenses because of its high oxygen permeability, so it is less burdensome to the eyes. On the other hand, silicone hydrogels tend to have insufficient wettability and lubricity because they contain waterproof silicone. Therefore, surface hydrophilization by a surface modification method and surface hydrophilization by mixing a hydrophilic polymer into a lens composition before curing have been studied. Currently, there are various methods of provid...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): C08G77/395C08F290/06C08G77/20C08G77/30G02C7/04
CPCG02C7/04C08G77/30C08G77/20C08F290/068C08G77/38C08L83/08C08G77/395C08F230/02C08F226/10C08F230/08C08F222/1006C08F290/148
Inventor 松冈阳介鹿取茜岩切规郎高岛柊五反田龙矢坂元伸行
Owner NOF CORP
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap