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Application of vaccinium dunalianum wight or extract thereof in preparation of medicines or health-care products for preventing and treating hepatic fibrosis

A technology of liver fibrosis and extract, which is applied in the field of medicine, can solve problems such as no literature reports, and achieve the effect of market demand and promising prospects, simple extraction process, and high safety

Inactive Publication Date: 2020-11-17
KUNMING UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Quezui tea has a complete range of amino acids and is rich in mineral elements and nutrients. However, there are no literature reports on the prevention and treatment of liver fibrosis in Quezui tea or its extracts at home and abroad.

Method used

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  • Application of vaccinium dunalianum wight or extract thereof in preparation of medicines or health-care products for preventing and treating hepatic fibrosis
  • Application of vaccinium dunalianum wight or extract thereof in preparation of medicines or health-care products for preventing and treating hepatic fibrosis
  • Application of vaccinium dunalianum wight or extract thereof in preparation of medicines or health-care products for preventing and treating hepatic fibrosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Embodiment 1: the preparation of sparrow beak tea extract

[0023] In this example, Quezui tea was collected from Chuxiong, Yunnan, and after natural drying, it was powdered to obtain a Quezui tea sample; 100g of Quezui tea sample was weighed, and the ratio of solid to liquid was g:mL=1:10. % methanol aqueous solution was extracted with ultrasonic assistance for 30 minutes, filtered, and the filter residue was extracted twice, and the filtrates were combined, concentrated and freeze-dried to obtain the sparrow mouth tea extract.

Embodiment 2

[0024] Example 2: Application of CCl 4 Establish a model of liver fibrosis by induction method, and observe the preventive effect of sparrow beak tea extract on liver fibrosis through animal model experiments

[0025] 1. Establishment of liver fibrosis model and experimental process

[0026] Taking male Kunming mice (6-8 weeks, weight 21-23g) as the research object, after mass concentration of 25% carbon tetrachloride (CCl 4 , diluted with peanut oil) to establish a liver fibrosis model twice a week for a total of eight weeks; with silymarin (Silibinin) as a positive control, the preventive effect on liver fibrosis was evaluated by gavage of sparrow tea extract; mice were purchased After adapting to the standard environment for seven days, the mice were divided into groups (8 mice in each group), and the mice were fed according to the conventional feeding method. The specific experimental procedure and grouping were as follows:

[0027] Blank control group (Control): given p...

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Abstract

The invention discloses application of vaccinium dunalianum wight or an extract thereof, namely application of vaccinium dunalianum wight or an extract thereof in preparation of medicines or health care products for preventing or / and treating hepatic fibrosis, and belongs to the technical field of natural medicine development or medicine. According to the application, experimental results show that the vaccinium dunalianum wight extract has a certain prevention and treatment effect on hepatic fibrosis; the vaccinium dunalianum wight is high in safety and low in price, and raw materials are easy to obtain; and the vaccinium dunalianum wight or the extract thereof has good development and application prospects in preparation of medicines or health care products for preventing and treating hepatic fibrosis diseases.

Description

technical field [0001] The invention relates to the application of sparrow mouth tea or its extract in the preparation of medicines or health care products for preventing or / and treating liver fibrosis, and belongs to the technical field of medicine. Background technique [0002] Liver fibrosis is a common pathological process of various chronic liver diseases, and it is also an inevitable process of liver cirrhosis and hepatocellular carcinoma. Many factors can promote the occurrence of liver fibrosis, such as alcohol intake, viral infection, parasites, and chemical toxicity. Long-term and repeated exposure to these pathogenic factors will eventually lead to the destruction of the normal structure of the liver, cell death, and liver dysfunction. disorder. The main pathological changes of liver fibrosis are degeneration and necrosis of liver cells accompanied by a large number of inflammatory cell infiltration, and the loss of extracellular matrix (ECM) in the liver with sm...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/45A61P1/16A23L33/105
CPCA61K36/45A61P1/16A23L33/105A23V2002/00A23V2200/30A23V2250/21A23V2300/14
Inventor 程桂广邓晓翠孙朋真李梦成曹建新赵天瑞刘亚平
Owner KUNMING UNIV OF SCI & TECH
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