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Novel copper metal complex and preparation method and application thereof

A technology of complexes and copper metals, applied in copper organic compounds, 1/11 group organic compounds without C-metal bonds, pharmaceutical formulations, etc., can solve the problems of severe toxicity and side effects, and achieve low equipment requirements and simple preparation methods , good anticancer activity

Pending Publication Date: 2020-11-20
GUANGXI NORMAL UNIV FOR NATITIES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, platinum-based anticancer drugs have relatively large toxic and side effects. Cancer patients receiving treatment usually suffer from severe toxic and side effects such as bone marrow suppression, such as thrombocytopenia, nausea and vomiting, and kidney and nerve damage. Therefore, non-platinum anticancer drugs with less toxicity are studied. Still one of the main directions of anticancer drug research

Method used

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  • Novel copper metal complex and preparation method and application thereof
  • Novel copper metal complex and preparation method and application thereof
  • Novel copper metal complex and preparation method and application thereof

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preparation example Construction

[0037] In some embodiments of the present invention, a method for preparing the above-mentioned novel copper metal complex is also provided, comprising the following steps: weighing 4-chloro-3-nitrobenzoic acid and 2,2'-bipyridyl into a beaker, adding The solvent was stirred and dissolved to make a mixed solution; another copper nitrate trihydrate was placed in a beaker, and the solvent was added to dissolve to obtain a light blue clear copper nitrate solution; under stirring, the copper nitrate solution was added dropwise to the mixed solution; Adjust in the range of 5 to 7, seal the film and puncture the holes and let it stand for 6-9 days to obtain blue crystals, which are the new copper metal complexes.

[0038] In order to fully react the ligand raw materials and obtain the target complex, in some preferred embodiments, the molar ratio of 4-chloro-3-nitrobenzoic acid, 2,2'-bipyridine, and copper nitrate trihydrate is 3: 0.8-1.2: 0.8-1.2.

[0039] In order to make the raw...

Embodiment 1

[0045]Synthesis of the complex: Weigh 4-chloro-3-nitrobenzoic acid (0.3mmol) and 2,2'-bipyridine (0.08mmol) into a beaker, add 5mL methanol and stir to dissolve to make a mixed solution; Take copper nitrate trihydrate (0.08mmol) and place it in a beaker, add 10mL of methanol to dissolve it, and obtain a slightly blue clear copper nitrate solution; under stirring, add the copper nitrate solution dropwise to the mixed solution within 20min; adjust the pH to 5. After sealing the film and piercing holes for 6 days, a blue crystal is obtained, which is the new copper metal complex.

Embodiment 2

[0047] Synthesis of the complex: Weigh 4-chloro-3-nitrobenzoic acid (0.3mmol) and 2,2'-bipyridine (0.1mmol) into a beaker, add 5mL of methanol and stir to dissolve to make a mixed solution; Take copper nitrate trihydrate (0.1mmol) and place it in a beaker, add 10mL of methanol to dissolve it, and obtain a slightly blue clear copper nitrate solution; under stirring, add the copper nitrate solution dropwise to the mixed solution within 30min; adjust the pH to Within the range of 6, after sealing the film and puncturing the hole for 7 days, blue crystals are obtained, which is the new copper metal complex; the yield is about 52.3%.

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Abstract

The invention provides a novel copper metal complex and a preparation method and application thereof, and belongs to the technical field of medicine synthesis. The coordination structure diagram of the copper complex is shown in Figure 1 in the specification. The preparation method of the novel copper metal complex comprises the following steps: weighing 4-chloro-3-nitrobenzoic acid and 2, 2'-dipyridyl, putting the 4-chloro-3-nitrobenzoic acid and the 2, 2'-dipyridyl into a beaker, adding a solvent, stirring and dissolving to prepare a mixed solution; putting copper nitrate trihydrate into a beaker, and adding a solvent for dissolving to obtain a light blue clear copper nitrate solution; dropwise adding the copper nitrate solution into the mixed solution in a stirring state; adjusting thepH value to be within the range of 5-7, sealing a film, pricking holes and standing for 6-9 days to obtain a blue crystal, namely the novel copper metal complex. The novel copper metal complex provided by the invention has good anti-cancer activity, and the preparation method is simple.

Description

【Technical field】 [0001] The invention relates to the technical field of drug synthesis, in particular to a novel copper metal complex, its preparation method and application. 【Background technique】 [0002] Cancer is usually treated with radiation, surgery, chemotherapy and targeted therapy, or a combination of the above methods. Surgery and radiation therapy can only ensure that there are no residual cancer cells in the surgical area. Chemotherapy is a treatment method that uses some chemical substances to kill cancer cells. The drugs used in chemotherapy generally identify cancer cells through high-speed cell division. Therefore, high-speed growth cells (bone marrow cells, hair follicle cells, etc.) will also be affected by chemotherapy drugs. complication. Targeted therapy is a treatment method with the ability of target recognition. The surface of cancer cells usually contains specific proteins that have not been found in normal cells. Targeted drugs can use these prot...

Claims

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Application Information

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IPC IPC(8): C07F1/08A61P35/00A61K31/555
CPCC07F1/08C07F1/005A61P35/00
Inventor 曾振芳韦友欢黄秋萍李致宝蔡杰慧郭洋洋郑广进刘子露方小红
Owner GUANGXI NORMAL UNIV FOR NATITIES
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