Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Targeted chitosan cross-linked gel and its preparation method and application

A technology of chitosan cross-linking and cross-linking of chitosan, which is used in pharmaceutical formulations, medical preparations with inactive ingredients, and medical preparations containing active ingredients, etc., to achieve enhanced circulation stability, good pH buffering capacity, The efficacy of safe and efficient drug delivery

Active Publication Date: 2022-05-31
DALIAN NATIONALITIES UNIVERSITY
View PDF5 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The technical problem to be solved by the present invention is to overcome the defects of existing chitosan drug carriers, to provide materials containing imidazole cross-linked chitosan and hyaluronic acid targeting structure and its preparation method

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Targeted chitosan cross-linked gel and its preparation method and application
  • Targeted chitosan cross-linked gel and its preparation method and application
  • Targeted chitosan cross-linked gel and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] imidazole-4,5-dicarboxylic acid dicarboxylic acid hydrazide

Embodiment 2

Embodiment 3

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
concentrationaaaaaaaaaa
molecular weightaaaaaaaaaa
molecular weightaaaaaaaaaa
Login to View More

Abstract

The invention provides a kind of chitosan cross-linked gel and its preparation method and application, the method utilizes chitosan and imidazole-4,5-dicarboxylate dimethyl to prepare imidazole cross-linked chitosan, and adopts Coated with hyaluronic acid, the gel has strong proton buffering capacity and drug loading function, and has CD44 targeting, which can be used as drug excipients and has broad application prospects.

Description

Targeted chitosan cross-linked gel and preparation method and application thereof technical field The present invention relates to a kind of targeting chitosan cross-linked gel material, specifically, relate to a kind of surface-coated hyaluronan The acid and imidazole cross-linked chitosan material and the preparation method and application thereof belong to the technical field of biomedicine. Background technique Nanogel has the advantages of high stability, good biocompatibility and large drug load, which can prevent drug degradation and Clearance of the circulatory system. Loading various molecules such as deoxyribonucleic acid, ribonucleic acid, protein, and inorganic materials on nanocapsules In the gel structure, it helps to improve the residence time of drugs in the systemic circulation and their biocompatibility, so nanogels can be used as For the new transport carrier. Chitosan (CS) is a kind of chitosan derivative, by β-1,4-linked glucosamine and a smal...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/06A61K47/36A61K47/54A61K45/00
CPCA61K9/06A61K47/36A61K47/545A61K45/00
Inventor 张树彪陈会英范雪枫蓝浩铭支德福
Owner DALIAN NATIONALITIES UNIVERSITY
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com