Application of combined medicine for relieving or treating constipation

A technology for treating constipation and drugs, which is applied in the field of medicine, can solve the problems of low total effective rate and easy recurrence, and achieve the effects of reducing the amount of medication, improving clinical symptoms and signs, and relieving constipation

Pending Publication Date: 2020-12-04
LUNAN PHARMA GROUP CORPORATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] The technical problem to be solved by the present invention is to provide a new combined drug scheme for the current situation that the existing drugs for treating constipation have low total effective rate and are prone to relapse.

Method used

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  • Application of combined medicine for relieving or treating constipation
  • Application of combined medicine for relieving or treating constipation
  • Application of combined medicine for relieving or treating constipation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Embodiment 1. Research on the Effects of Outlet Obstruction Rat Constipation Model

[0026] 1. Materials and methods

[0027] Experimental animals: SD rats, half male and half female, weighing 180-220 g, SYXK (Lu) 2017 0006, provided by Jining Food and Drug Inspection and Testing Center; adaptive feeding for one week before the experiment.

[0028] 2. Drugs and reagents:

[0029] Puji hemorrhoid suppository, commercially available, Shandong New Times Pharmaceutical Co., Ltd.;

[0030] Mosapride citrate tablets, commercially available, Lunan Bite Pharmaceutical Co., Ltd.;

[0031] ELISA kit, commercially available, Nanjing Senbega Biotechnology Co., Ltd.

[0032] 3. Modeling method:

[0033] The model was established by ligation of incomplete rectum. Rats were randomly divided into normal group, model group, control group 1, control group 2, experimental group 1, experimental group 2 and experimental group 3, with 10 rats in each group, half male and half male. The...

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Abstract

The invention belongs to the field of medicines, and in particular relates to application of a combined medicine for relieving and treating constipation. According to the invention, a Puji haemorrhoids suppository and mosapride are used in combination; the effective dose of the Puji haemorrhoids suppository and the mosapride is adjusted through the strong synergistic effect of the Puji haemorrhoids suppository and the mosapride; the effects of significantly relieving constipation signs and significantly improving outlet obstruction type constipation are achieved; compared with normal clinicalmedication, the dosage is greatly reduced; the total rate is high; the recurrence rate is low; and furthermore, the combined medicine disclosed by the invention is larger in safety range and is easilyaccepted by patients.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a new application of a combination medicine for alleviating or treating constipation. Background technique [0002] Constipation is a common clinical symptom caused by various diseases. Functional constipation (FC) has no obvious organic lesions, and its pathogenesis is complex, which may be related to factors such as bad eating habits, defecation habits, living habits or bad drug habits, psychological factors, congenital abnormalities, hormones, and long-term conscious suppression of defecation , The clinical manifestations are: difficulty in defecation, dry stool, reduced frequency of defecation, feeling of falling after defecation, and prolonged defecation time. From the perspective of dynamic abnormalities, functional constipation can be divided into three categories: slow transit constipation, outlet obstruction constipation, and mixed constipation. [0003] Outlet obst...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/413A61P1/10A61K31/045A61K31/5375
CPCA61K9/0031A61K9/0053A61K31/045A61K31/5375A61K35/413A61P1/10A61K2300/00
Inventor 黄志艳叶士莉
Owner LUNAN PHARMA GROUP CORPORATION
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