Calibrator for fructosamine detection and detection kit using calibrator

A detection kit and fructosamine technology, applied in the field of biological detection, can solve the problems of change in detection value, slowness, difficult extraction of glycated serum proteins, etc., and achieve the effects of low cost, accurate detection results, and good transportation stability.
CN112067562APending Publication Date: 2020-12-11海丰生物科技(北京)有限公司
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
海丰生物科技(北京)有限公司
Publication Date
2020-12-11

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Abstract

The invention discloses a calibrator for fructosamine detection and a detection kit applying the calibrator. The calibrator is bovine serum albumin. The invention also discloses a detection kit for determining fructosamine. The detection kit adopts the bovine serum albumin as the calibrator. According to the invention, on the basis of using 1-deoxy-1-morpholine fructose (DMF) as a first-grade standard substance and using a nitrotetrazolium blue chloride (NBT) reduction method to determine the fructosamine (FA), the method for determining the fructosamine (FA) by using bovine serum albumin as the calibrator (third grade) is reasonably established; the method provided by the invention can make up for defects of DMF as a standard substance in aspects of a molecular structure, a reaction rateand reaction condition sensitivity; and meanwhile, advantages of an accurate sample detection result, low cost and better transportation stability are possessed.
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Description

technical field

[0001] The invention relates to the technical field of biological detection, in particular to a calibrator for the detection of fructosamine and a detection kit using the same. Background technique

[0002] Fructosamine, also known as glycosylated serum protein, is a substance formed by protein in plasma during the non-enzymatic saccharification of glucose. Since the half-life of plasma protein is 17 days, fructosamine can reflect the blood sugar levels of diabetic patients within 1 to 3 weeks before testing. Average blood sugar level. To a certain extent, it makes up for the deficiency that glycosylated hemoglobin cannot reflect the change of blood sugar concentration in a short period of time. Determination of fructosamine is rapid and inexpensive (chemical method) and is a good indicator of diabetes control.

[0003] Since Johnson established the nitroblue tetrazolium (NBT) reduction method for the determination of fructosamine (FA) in 1982, it has been ...

Claims

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