The invention belongs to the field of additives for cement clinker production, and particularly relates to a desulfurization composition, a desulfurizing agent and application of the desulfurizing agent in tail gas desulfurization during cement clinker production. The desulfurization composition at least comprises a sulfur fixing agent and an oxidizing agent, wherein the oxidizing agent comprisesan oxidizing agent containing metal elements; the oxidizing agent containing metal elements is selected from one or more of a lithium-containing oxidizing agent, a platinum-containing oxidizing agent,a manganese-containing oxidizing agent, a sodium-containing oxidizing agent and a potassium-containing oxidizing agent. The actual using amount of the desulfurizing agent is small, the chemical stability is high; after a catalyst is added, the decomposition temperature of CaCO3 is reduced; CaO is rapidly generated to promote adsorption of SO2 in preheating; the goals of sulfur fixing and reduction of SO2 emission are realized; the price is low, no ammonia gas escapes, the composition and desulfurizing agent are non-corrosive, harmless, nontoxic, and non-irradiative, meet the requirements of GB4915-2013 for cement production, and avoid the phenomenon such as caking, scaling, and the like, and meanwhile, the transportation stability and thermal stability of the desulfurizing agent are good.