Nitrofurazone washing fluid, preparation method and application thereof
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A nitrofuracil and flushing liquid technology, applied in the field of medicine, can solve the problems of lack of lubricity, neurological symptoms such as auditory hallucinations, visual hallucinations, hallucinations, dizziness, insomnia, multiple peripheral neuritis, allergic reactions and the like
Inactive Publication Date: 2011-10-12
85 HOSPITAL OF PEOPLES LIBERATION ARMY
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[0020] 1. Those who are allergic to furan drugs should not use it
[0021] 2. Allergic reactions after oral administration, such as shock, asthma, shortness of breath, rash, etc.; gastrointestinal reactions, drug fever, eosinophilia and neurological symptoms such as auditory hallucinations, visual hallucinations, hallucinations, dizziness, insomnia and multiple seizures Peripheral neuritis, etc.
[0113] Its disadvantage is that the fibers washed with it feel bad
Disadvantages of lead salt stabilizers: poor dispersibility, high toxicity, initial coloring, difficult
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[0563] Example 1,
[0564] Nitrofurazone 0.2g, Solutol HS 15 1g, sodium chloride 900g, adjust pH to 5.0, and dilute to 1000 mL with water for injection.
[0565] Preparation method: Take nitrofurazone, Solutol HS 15, sodium chloride, heat an appropriate amount of water for injection to dissolve, adjust the pH to 5.0, add 1g of activated carbon for injection, heat and boil for 30 minutes, stir, decarburize and filter until clear, add injection Make 1000ml with water, potting, and sterilizing at 115°C for 30 minutes.
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[0566] Example 2,
[0567] Nitrofurazone 0.2g, Solutol HS 15 10g, sodium chloride 900g, adjusted to pH 5.0, dilute to 1000 mL with water for injection.
[0568] Preparation method: Take nitrofurazone, Solutol HS 15, sodium chloride, heat an appropriate amount of water for injection to dissolve, adjust the pH to 5.0, add 1g of activated carbon for injection, heat and boil for 30 minutes, stir, decarburize and filter until clear, add injection Make 1000ml with water, potting, and sterilizing at 115°C for 30 minutes.
Example Embodiment
[0569] Example 3.
[0570] Nitrofurazone 0.2g, Solutol HS 15 100g, sodium chloride 900g, adjust the pH to 5.0, and dilute to 1000 mL with water for injection.
[0571] Preparation method: Take nitrofurazone, Solutol HS 15, sodium chloride, heat an appropriate amount of water for injection to dissolve, adjust the pH to 5.0, add 1g of activated carbon for injection, heat and boil for 30 minutes, stir, decarburize and filter until clear, add injection Make 1000ml with water, potting, and sterilizing at 115°C for 30 minutes.
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Abstract
The invention discloses a novel nitrofurazone washing fluid, which mainly comprises an active component nitrofurazone, a solubilizing agent polyethyleneglycol 15-hydroxyl stearate and a solvent injection water. Furthermore, one or more of cosolvent, pH regulator, osmotic pressure regulator and stabilizing agent can be added into the washing fluid. In the washing fluid, a novel solubilizer Solutol HS 15 has low haemolysis, extremely low histamine liberation and higher physiological tolerance, so that safety of clinical administration and compliance of patients are remarkably improved; the washing fluid has excellent stability and longer validity, and higher administration convenience is given to clinical doctors; and the washing fluid has better storage and transportation stability, higher clinical administration safety and patient compliance. The washing fluid has a simple preparation process, convenience in quality control, lower production cost and industrial production.
Description
technical field [0001] The present invention relates to the technical field of medicine, in particular to a medical product for wound disinfection, more specifically to a wound antibacterial rinse solution for reducing the microbial content of the wound and its preparation method and application, and more specifically The invention relates to a nitrofurazone flushing solution and a preparation method and application thereof. Background technique [0002] (1) Basic situation of nitrofurazone research [0003] 1 Overview [0004] Furacilin Irrigation Solution (Furacilin Irrigation Solution) is generally divided into Furacilin Irrigation Solution and Sterilized Furacilin Irrigation Solution. It is a commonly used clinical preparation in medical institutions and is recorded in "Chinese Hospital Preparation Standards" (Second Edition of Western Medicine Preparations). [0005] As a local antibacterial drug commonly used in clinical practice in hospitals, nitrofurazone solution ...
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