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Polypeptide analogue and application thereof in medicines for intervention treatment of cerebral hemorrhage

A technology of analogs and peptides, which is applied in the field of peptide analogs and its application in the intervention and treatment of cerebral hemorrhage drugs, can solve the problems of unclear key mechanism and lack of treatment methods, achieve good therapeutic effect, relieve anxiety, improve The effect of learning and memory dysfunction

Inactive Publication Date: 2020-12-15
NANTONG UNIVERSITY
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0008] The present invention provides a polypeptide analog and its application in drugs for the intervention and treatment of cerebral hemorrhage, which solves the technical problems in the prior art that the key mechanism of cerebral hemorrhage is still unclear and there is no exact and effective treatment method at present.

Method used

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  • Polypeptide analogue and application thereof in medicines for intervention treatment of cerebral hemorrhage
  • Polypeptide analogue and application thereof in medicines for intervention treatment of cerebral hemorrhage
  • Polypeptide analogue and application thereof in medicines for intervention treatment of cerebral hemorrhage

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Embodiment 1

[0045] Embodiment 1: A kind of polypeptide analog, in described polypeptide analog, polypeptide is Tat-CIRP-CMA, wherein Tat is the transmembrane structural sequence of 11 amino acids, and CIRP is 15 on the cold-inducible protein CIRP with the highest affinity with MD2 CMA is a 14-amino acid signal peptide sequence targeting the proteasome.

[0046] The 15 amino acid sequences with the highest affinity: GRGFS RGGGD RGYGG.

[0047] The polypeptide analogs include: amino acid fragments in the transcriptional transactivator Tat, amino acid fragments in the cold-inducible protein CIRP, and a key sequence KFERQKILDQRFFE necessary for autophagy mediated by molecular chaperones.

[0048] The 47th-57th amino acid fragment in the transcriptional transactivator Tat is located at the N-terminal of the fusion protein, the 111th-125th amino acid fragment in the cold-inducible protein CIRP is located in the middle of the fusion protein, and the molecular chaperone mediator The key sequence...

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Abstract

The invention discloses a polypeptide analogue and an application thereof in medicines for intervention treatment of cerebral hemorrhage. Polypeptide in the polypeptide analogue is Tat-CIRP-CMA, wherein Tat is a membrane-penetrating structure sequence of 11 amino acids, cold-induced protein CIRP is a 15 amino acid sequence with the highest affinity with MD2, and CMA is a signal peptide sequence of14 amino acids of targeted proteasome; and the polypeptide analogue has a good treatment effect on a cerebral hemorrhage model, and the polypeptide analogue studied in the invention possibly furtherplays an effective drug role.

Description

technical field [0001] The invention relates to the technical field of cerebral hemorrhage drugs, in particular to a polypeptide analog and its application in drugs for the intervention and treatment of cerebral hemorrhage. Background technique [0002] Brain injury after cerebral hemorrhage is a complex pathophysiological process involving multiple genes and signaling pathways. The basic pathological changes after cerebral hemorrhage include primary injury and secondary injury (Feigin, V.L., Lawes, C.M., Bennett, D.A. and Anderson, C.S. (2003). Stroke epidemiology: a review of population-based studies of incidence, prevalence, and case-fatality in the late 20th century. Lancet Neurol 2, 43-53.). [0003] The primary injury is mainly mechanical injury caused by tissue destruction during bleeding, expansion of hematoma, and increased intracranial pressure. Secondary injury mechanisms include inflammatory response, apoptosis, necrosis, erythrocyte lysis, and brain edema forma...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K19/00A61K49/00A61K38/17A61K47/64A61P29/00A61P25/22A61P25/00A61P7/04A61P9/10
CPCA61K38/00A61K49/0008A61P7/04A61P9/10A61P25/00A61P25/22A61P29/00C07K14/47C07K2319/02C07K2319/10
Inventor 骆倩倩姜辉李美琦王国华叶莉莎朱俐
Owner NANTONG UNIVERSITY
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