Method for inducing nerve cells and stem cells to differentiate by utilizing acoustic fluid

Abstract

The invention relates to a method for inducing nerve cells and stem cells to differentiate by utilizing an acoustic fluid. Induced differentiation of the nerve cells and the stem cells is realized byutilizing an acoustic fluid effect generated by a micro-nano piezoelectric bulk acoustic resonator capable of generating GHz waveband hypersonic sound. By changing the input power of the resonator andthe distance between the resonator and cells, the intensity of the acoustic fluid is adjusted. The cells of the invention can realize high-efficiency differentiation without intervention of externaldrugs; under the stimulation effect of the acoustic fluid, the nerve cells and the stem cells can be differentiated within a few minutes; and, based on the micron size of the micro-nano piezoelectricbulk acoustic resonator, the action range of the generated acoustic fluid is matched with the size of the resonator, so that differentiation induction of single cells can be realized by reducing the size of the resonator and the action range of the acoustic fluid. Based on the advantage that the micro-nano piezoelectric bulk acoustic resonator is small in size and easy to integrate, the resonatoris designed and produced in an array mode; and induction of large-range cell differentiation can be achieved.

Description

technical field [0001] The invention relates to a method for inducing the differentiation of nerve cells and stem cells, in particular to a method for inducing the differentiation of nerve cells and stem cells by using the acoustic fluid effect produced by a micro-nano piezoelectric resonator in a solution. Background technique [0002] Nervous system diseases, such as Alzheimer's disease, Parkinson's disease, etc., are all caused by damage to the nervous system caused by neuron atrophy, nerve connection breakdown, etc. Stem cells have the potential of multi-directional differentiation, and have great potential in the treatment of tissue and organ damage and functional failure. Therefore, an efficient and convenient method to regulate nerve cell activity and promote stem cell differentiation and regeneration has become extremely important. In order to solve this problem, various regulation methods such as electromagnetic stimulation, optogenetics, and acoustic stimulation h...

AI Technical Summary

Problems solved by technology

[0004] In the current neuromodulation methods, non-invasive methods cannot focus on small areas, which is not conducive to the stimulation of cells at specific locations; while methods that can achieve precise stimulation of small areas require the use of surgical methods to deliver extracorporeal substances to the target area, resulting in A series of side effects such as human rejection and inflammation

Images