PTPN2-blocked immune cell and application and preparation thereof
A technology of immune cells and NKT cells, applied in the field of PTPN2-blocking immune cells and their applications and preparations, can solve the problems of solid tumors without good treatment effect, low clinical response rate, off-target, etc., to enhance the killing function and reduce exhaustion. , to avoid toxic effects
Inactive Publication Date: 2020-12-22
GUANGDONG XIANKANGDA BIOTECH CO LTD
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Abstract
The invention relates to the field of biological cells, and particularly relates to a PTPN2-blocked immune cell and application and a preparation thereof. The PTPN2-blocked immune cell expresses a chimeric antigen receptor, the PTPN2 function in the immune cell is blocked, and the immune cell can secrete an anti-PD-1 antibody. The invention provides a method for killing tumors and reversing exhaustion. The PTPN2-blocked function is innovatively combined with CAR and anti-PD-1 immunoregulation, so that the tumor killing activity of the immune cell is improved, and the effect of curing tumors isachieved.
Application Domain
Antibody mimetics/scaffoldsNucleic acid vector +14
Technology Topic
Biology cellCAR - Chimeric antigen receptor +8
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