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Method and system for evaluating kidney reserve function and application thereof

A renal and functional technology, applied in the field of evaluating renal reserve function, to achieve the effect of easy application and promotion, high acceptance, and avoiding the risk of radiation exposure

Inactive Publication Date: 2020-12-22
PEKING UNION MEDICAL COLLEGE HOSPITAL CHINESE ACAD OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In addition, there is only one domestic study using radionuclide renal imaging to evaluate renal reserve function

Method used

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  • Method and system for evaluating kidney reserve function and application thereof
  • Method and system for evaluating kidney reserve function and application thereof
  • Method and system for evaluating kidney reserve function and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Embodiment 1 renal reserve function evaluation method

[0040] Preparation before the test:

[0041] 1) Renal function and urine routine test were normal before the test, and there was no history of protein allergy in the past;

[0042] 2) Measure height and weight.

[0043] 3) Fasting for more than 8 hours before the test, and drinking water is not restricted;

[0044] 4) Prepare in advance: clean urine bucket, measuring cup, 3L pure water, water cup with scale, whey protein powder (By-Health, protein content 75%), urinary catheter, venous blood collection tube and blood collection device;

[0045] 5) On the day of the test, keep sitting or lying down after washing normally in the morning, and avoid excessive standing and walking;

[0046] 6) Get up on an empty stomach in the morning on the day of the test, do not drink water, and do not restrict urination;

[0047] 7) Urine should be drained before the test starts.

[0048] Experimental procedure:

[0049] 1) Drin...

Embodiment 2

[0069] Application of Example 2 Evaluation of Renal Reserve Function

[0070] The present invention evaluates the renal reserve function of 19 healthy controls according to the method of Example 1, and establishes the normal value of the renal reserve function of the Chinese population. The creatinine clearance rate of 19 healthy controls after protein loading was significantly higher than the baseline (173.7±30.8 vs 140.9±31.5ml / min / 1.73m 2 ;P figure 2 A); CysC-eGFR results are similar ( figure 2 B), the baseline refers to the GFR value calculated before protein load, that is, the BSA-corrected creatinine clearance rate in the corresponding formula min(负荷前) or (CysC-eGFR) min(负荷前) . figure 2 The dotted line in the middle indicates the point of protein loading, the left side of which is the two values ​​measured before protein loading (choose the smallest as the baseline, that is, the value before loading), and the right side is the three values ​​measured after protein l...

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Abstract

The invention discloses a method for evaluating a kidney reserve function, which comprises the following steps of: obtaining physiological parameters of a urine Cr value, a blood Cr value and a cystatin C value by enabling a subject to take in high protein through diet and utilizing urine and blood specimens collected in vitro, and conducting calculating to obtain an intermediate result of the kidney reserve function. The method for evaluating the kidney reserve function has the advantages that the process is standardized, hematuresis specimen collection and index detection are mature clinically, and clinical application and popularization are easy. The protein powder is orally taken, thus the state is closer to the physiological state of a human body and the patient acceptance degree is high.

Description

technical field [0001] The present invention relates to a method and system for evaluating renal reserve function and application thereof. Background technique [0002] The concept of renal functional reserve (RFR) was proposed as early as 1983 by Bosch et al. It is believed that the kidney does not exert its maximum filtering function under normal physiological conditions, and its reserve function can be used to adapt to stress or disease. Changes in the internal environment of the human body. In 1993, Fliser et al. found that a high-protein diet could increase the glomerular filtration rate (GFR, glomerular filtration rate) by 25% to 60% and last for several hours, and believed that the change of GFR before and after protein load was a reliable method to evaluate the renal reserve function . This method has been used to evaluate the renal reserve function in people with specific physiological states (the elderly, pregnant women, etc.) Decreased reserve function is assoc...

Claims

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Application Information

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IPC IPC(8): G01N33/50
CPCG01N33/50
Inventor 陈丽萌赵冰彬施潇潇夏鹏
Owner PEKING UNION MEDICAL COLLEGE HOSPITAL CHINESE ACAD OF MEDICAL SCI
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