Traditional Chinese medicine composition for preventing and treating colorectal adenoma, and preparation method and application thereof

A composition and polyp technology, applied in drug combinations, antitumor drugs, pharmaceutical formulations, etc., can solve problems affecting patient compliance, abdominal discomfort, mild to moderate anemia, etc., to improve intestinal mucosal bleeding, prevent occurrence and Development and improvement of acid reflux symptoms

Inactive Publication Date: 2020-12-25
JIANGXI POZIN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] "Jisheng Wumei Wan" involves a prescription containing black plum and silkworm, which is used to treat various adenomatous polyps of the digestive tract, including gastric polyps, gallbladder polyps and intestinal adenomatous polyps, among which intestinal adenomatous polyps are It is an important precancerous lesion of the intestine, but the effect of Jisheng Wumei Pill on the treatment of intestinal adenomatous polyps is uncertain. After taking Wumei Wan, the clinical symptoms such as acid reflux and nausea were obvious, which affected the patient's compliance with treatment.
The inventor’s previous research results, the Chinese patent document CN107875210A discloses a traditional Chinese medicine prescription involving black plum and silkworm. After clinical application, it is found that the prescription of black plum and silkworm is effective in treating intestinal adenomatous polyps, but it is easy to cause nausea and acid reflux in patients. , mucosal bleeding, abdominal discomfort and mild to moderate anemia

Method used

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  • Traditional Chinese medicine composition for preventing and treating colorectal adenoma, and preparation method and application thereof
  • Traditional Chinese medicine composition for preventing and treating colorectal adenoma, and preparation method and application thereof
  • Traditional Chinese medicine composition for preventing and treating colorectal adenoma, and preparation method and application thereof

Examples

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Effect test

Embodiment 1

[0029] The traditional Chinese medicine composition for preventing and treating intestinal adenomatous polyps is made of the following traditional Chinese medicine raw materials in the following weight ratio: black plum: silkworm: sophora japonica = 1:4:3.

[0030] Preparation and dosage: first mix the raw materials in the weight ratio, add 10 times the mass of 30% ethanol solution, heat and reflux for extraction for 60 minutes, concentrate the extract under reduced pressure until it has no alcohol smell, and dissolve it in 200ml of hot water , taken warmly twice, and the daily dose is 60g in terms of composition.

[0031] The beneficial effects of the Chinese medicine compound preparation of the present invention are set forth below through test examples, including animal pharmacodynamic tests and clinical efficacy tests.

Embodiment 2

[0033] The traditional Chinese medicine composition for preventing and treating intestinal adenomatous polyps is made of the following traditional Chinese medicine raw materials in the following weight ratio: black plum: silkworm: sophora japonica = 1:4:3.

[0034] Preparation and dosage: firstly pulverize the traditional Chinese medicine raw materials in the weight ratio with a pulverizer, and take the whole powder to make large honeyed pills, and the daily dosage is 60g according to the whole powder.

Embodiment 3

[0036] The traditional Chinese medicine composition for preventing and treating intestinal adenomatous polyps is made of the following traditional Chinese medicine raw materials in the following weight ratio: black plum: silkworm: sophora japonica = 1:4:3.

[0037] Preparation and dosage: first mix the raw materials in the weight ratio, add 10 times the quality of pure water, decoct for 40 minutes, take the juice and take it warmly twice, and the daily dosage is 60g based on the whole powder.

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Abstract

The invention relates to the technical field of traditional Chinese medicines, and in particular relates to a traditional Chinese medicine composition for preventing and treating colorectal adenoma. The traditional Chinese medicine composition is composed of the raw materials including dark plum, stiff silkworm and sophora flower in a weight ratio of 1:4:3. The invention further provides a preparation method of the traditional Chinese medicine composition and application of the traditional Chinese medicine composition in preparation of medicines for preventing and treating colorectal adenoma and preventing relapse of the colorectal adenoma. The traditional Chinese medicine composition provided by the invention can be used for specifically preventing the occurrence and development of colorectal adenoma, and is a relatively safe and more effective medicine for preventing and treating colorectal adenoma.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for preventing and treating intestinal adenomatous polyps, its preparation method and application. Background technique [0002] Intestinal adenomatous polyp (Colorectal adenoma, CRA) is an important precancerous lesion of colorectal cancer (CRC), and more than 90% of CRCs are caused by CRA canceration. It is manifested by abnormal crypt foci in the intestinal wall, increased exudation of inflammatory mediators in the lesion, and proliferation of mucosal epithelial cells in local intestinal tissue. The main types are tubular adenoma, villous adenoma, mixed adenoma and serrated adenoma. Features of CRA ① Very easy to relapse, with a recurrence rate of over 30% in one year and about 50% in 3 years. ② High carcinogenicity, the single canceration rate is 20-30%, and the multiple canceration rate is 30-80%. Endoscopic...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/736A61P1/00A61P35/00A61K35/64A61K36/489
CPCA61K35/64A61K36/489A61K36/736A61P1/00A61P35/00A61K2300/00
Inventor 付晓伶郭翠徐祎敏王珂韩馨悦李园孙栩秋
Owner JIANGXI POZIN PHARMA
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