Throat lozenge as well as preparation method and application thereof

A throat lozenge and xylitol technology, applied in the field of throat lozenges, can solve the problems of inability to cure or relieve atrophic and dry pharyngitis, decreased estrogen levels, submandibular gland gland atrophy, etc. Dry pharyngitis, increased expression, quality controllable effects

Inactive Publication Date: 2020-12-29
浙江康恩贝中药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, atrophic and sicca pharyngitis are mainly related to the estrogen level of women. The estrogen level of middle-aged and elderly women decreases, and the expression of aquaporin-5 (AQP-5) decreases, resulting in a slowed salivary flow rate and atrophy of the submandibular gland. Therefore, its pathology is different from that of common chronic pharyngitis. Taking commercially available throat lozenges cannot cure or relieve atrophic and dry pharyngitis.

Method used

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  • Throat lozenge as well as preparation method and application thereof
  • Throat lozenge as well as preparation method and application thereof
  • Throat lozenge as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Embodiment 1: throat lozenge preparation 1

[0039] A throat lozenge, comprising 90g of phylloxera, 30g of Houttuynia cordata, 30g of honeysuckle, 30g of white tea, 15g of bellflower, 15g of licorice, 400g of isomalt, 40g of xylitol, and 0.4g of natural menthol, and decocted from the above materials The paste is made into a candy shape.

[0040] (1), crush 90 g of the flowers under the leaves, 30 g of Houttuynia cordata, and 30 g of honeysuckle, add 7 times the volume of water to distill for 2 hours, collect the volatile component A, and collect the remaining part B for later use;

[0041] (2), pulverize 30g of white tea, 15g of Platycodon grandiflorum, and 15g of licorice, add 13 times the volume of water to distill for 3 hours, filter and collect filtrate C and filter residue D for later use, filter residue D is combined with the rest of B in step (1), add Extract with 7 times the volume of water for 3 hours, and collect the filtrate E by filtration;

[0042] (3), t...

Embodiment 2

[0046] Embodiment 2: throat lozenge preparation 2

[0047] A throat lozenge, comprising 60g of phylloxera, 20g of Houttuynia cordata, 50g of honeysuckle, 20g of white tea, 10g of bellflower, 30g of licorice, 200g of isomalt, 50g of xylitol, and 0.1g of natural menthol, and decocted from the above materials The paste is made into a candy shape.

[0048] (1), crush 60 g of the flowers under the leaves, 20 g of Houttuynia cordata, and 50 g of honeysuckle, add 5 times the volume of water and distill for 1 hour, collect the volatile component A, and collect the remaining part B for later use;

[0049] (2), 20 g of white tea, 10 g of Platycodon grandiflorum, and 30 g of Radix Glycyrrhiza are pulverized, add 10 times the volume of water, distill for 1 hour, filter and collect filtrate C and filter residue D for subsequent use, filter residue D merges with the remainder B in step (1), Add 5 times the volume of water to extract for 1 hour, and collect the filtrate E by filtration;

...

Embodiment 3

[0054] Embodiment 3: throat lozenge preparation 3

[0055] A throat lozenge, comprising 120g of phylloxera, 50g of Houttuynia cordata, 20g of honeysuckle, 50g of white tea, 30g of bellflower, 10g of licorice, 500g of isomalt, 20g of xylitol, and 1g of natural menthol.

[0056] (1), crush 120 g of the flowers under the leaves, 50 g of Houttuynia cordata, and 20 g of honeysuckle, add 10 times the volume of water and distill for 3 hours, collect the volatile component A, and collect the remaining part B for later use;

[0057] (2), 50 g of white tea, 30 g of Platycodon grandiflora, 10 g of Radix Glycyrrhizae are pulverized, add 15 times the volume of water and distill for 4 hours, filter and collect filtrate C and filter residue D for later use, filter residue D merges with the remainder B in step (1), Add 10 times the volume of water to extract for 5 hours, and collect the filtrate E by filtration;

[0058] (3), the obtained filtrate E is mixed with the filtrate C, and concentr...

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Abstract

The invention provides a throat lozenge as well as a preparation method and application thereof. The throat lozenge comprises the following components in parts by weight of 60-120 parts of full grassor roots of ainsliaea pertyoides, 20-50 parts of heartleaf houttuynia herb, 20-50 parts of flos lonicerae and 220.1-551 parts of an auxiliary material, and further comprises 20-50 parts of white tea,10-30 parts of radix platycodonis and 10-30 parts of radix glycyrrhizae, wherein the full grass or roots of ainsliaea pertyoides contains rich flavonoids, phenolic acids, nucleosides, sesquiterpene lactones and other compounds, has a synergistic effect after being compounded with heartleaf houttuynia herb and other traditional Chinese medicinal materials, and can effectively relieve inflammation,cough and other symptoms caused by throat dryness, and the prepared throat lozenge has the effect of obviously improving atrophic and dry pharyngitis. Besides, in order to improve the content stability of all medicinal components such as flavonoids and terpenoids and the like of the throat lozenge, a volatile oil recovery step is added on the basis of a conventional technical scheme, the transferrate of all the effective components reaches 90-95% through detection of the medicinal components, the throat lozenge has the advantages of economy and environmental protection, and the prepared throat lozenge is safe, effective and controllable in quality.

Description

technical field [0001] The invention relates to a compound preparation and its preparation method and application, in particular to a throat lozenge. Background technique [0002] Respiratory system diseases, especially throat diseases, are common and frequently-occurring diseases. Mild cases often have cough, chest pain, and breathing is affected. Severe cases have dyspnea, hypoxia, and even death due to respiratory failure. Pharyngitis can be divided into acute pharyngitis and chronic pharyngitis according to the duration of the disease. In recent years, due to air pollution, the incidence of acute and chronic pharyngitis patients in my country is on the rise. According to literature reports, the incidence of chronic pharyngitis accounts for 10-12% of throat diseases, mostly occurs in adults, and the incidence rate in cities is high, and it is gradually increasing. The recurrence rate of chronic pharyngitis is high, and its morbidity is related to environmental pollution...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/78A61K36/82A61K9/00A61K47/26A61P11/04
CPCA61K9/0056A61K36/28A61K36/346A61K36/355A61K36/484A61K36/78A61K36/82A61K47/26A61K2236/331A61K2236/39A61K2236/51A61K2236/53A61P11/04A61K2300/00
Inventor 吴华铃褚晓波金汉台金志文陈丽诗姚建标吴健虞利东祝雷强孙斌
Owner 浙江康恩贝中药有限公司
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