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Application of VX-765 in preparation of drug for preventing myocardial infarction necrosis

A VX-765, 1. The technology of VX-765 is applied in the application field of the preparation of drugs for the prevention of myocardial infarction necrosis, which can solve the problems of scarcity of donor sources, treatment costs, difficulty in wide application, and inability to reverse cardiac tissue damage.

Inactive Publication Date: 2020-12-29
TONGJI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Most of the current drug or device treatments can only relieve symptoms, but cannot reverse the damage to heart tissue
Although heart transplantation can completely improve the condition of the heart, it is difficult to be widely used clinically due to factors such as scarcity of donor sources, immune rejection, and expensive treatment costs.

Method used

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  • Application of VX-765 in preparation of drug for preventing myocardial infarction necrosis
  • Application of VX-765 in preparation of drug for preventing myocardial infarction necrosis
  • Application of VX-765 in preparation of drug for preventing myocardial infarction necrosis

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Experimental program
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Embodiment

[0034] Modeling of animal experiments: In the present invention, in order to search for proteins and genes that undergo significant changes in the process of myocardial infarction, the model mouse c57 was used to construct a myocardial infarction model. Firstly, the myocardial infarction model was constructed by ligating the left anterior descending coronary artery, see figure 1 .

[0035] After 24h and 72h after myocardial infarction, the infarction effect was detected. It can be seen that the cardiac contractility of the mice is greatly reduced, and the ejection fraction EF value of the mouse heart is significantly lowered, which proves that the infarction experiment is successful. See figure 2 and image 3 .

[0036] Figure 4 To detect the change of gene expression profile 72 hours after myocardial infarction, the change of pyroptosis pathway was analyzed by GESA: it can be seen that the genes negatively regulated by such pathway were significantly down-regulated, whic...

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Abstract

The invention relates to application of VX-765 in preparation of a drug for preventing myocardial infarction necrosis. A CASP1 inhibitor VX-765 is added to an extremely early myocardial infarction drug so as to significantly improve the occurrence of myocardial infarction, and the VX-765 can be used as a key molecule for early delaying myocardial infarction symptoms of myocardial infarction. Compared with the prior art, the VX-765 is used for intervening in the very early stage of myocardial infarction, the symptoms of myocardial infarction and myocardial damage can be delayed, and the activity of myocardial tissue Caspase1 of a VX-765 treatment group is obviously reduced within 72 hours after myocardial infarction; protein level also finds that the content of active CASP1 is also obviously reduced, which indicates that the VX-765 plays a significant effect; and therefore, the occurrence of myocardial infarction can be remarkably improved by adding the CASP1 inhibitor VX-765 in the very early stage of myocardial infarction, and the VX-765 can be used as the key molecule for delaying the symptoms of myocardial infarction in the early stage of myocardial infarction.

Description

technical field [0001] The invention relates to the field of medicine, in particular to the application of VX-765 in the preparation of medicines for preventing myocardial infarction necrosis. Background technique [0002] Coronary heart disease is a heart disease caused by atherosclerotic lesions in the coronary arteries that cause stenosis or blockage of the vessel lumen, resulting in myocardial ischemia, hypoxia or necrosis. AMI is a serious type of coronary heart disease, and it is the leading cause of death in my country One of the main reasons. Most of the current drug or device treatments can only relieve the symptoms, but they cannot reverse the damage to the heart tissue. Although heart transplantation can completely improve the state of the heart, it is difficult to be widely used clinically due to factors such as scarcity of donor sources, immune rejection, and expensive treatment costs. [0003] At present, the drugs for the early treatment of myocardial infarct...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/06A61P9/10
CPCA61K38/06A61P9/10
Inventor 李觉
Owner TONGJI UNIV