72 results about "Myocar dial" patented technology

Methods, compositions, and kits for repairing damaged myocardium and/or myocardial cells including the administration of stem cells, such as adult stem cells, optionally with cytokines are disclosed and claimed.

The invention describes the isolation and methods of use of a non-senescent pool of adult cardiac stem cells. In particular, a subset of adult cardiac stem cells with superior regenerative capacity is disclosed. Such cells were found to have immortal DNA. Compositions comprising the non-senescent stem cells are also described. In addition, the present invention provides methods for repairing aged myocardium or damaged myocardium using the isolated non-senescent adult cardiac stem cells.

A method to determine myocardial wall dynamics and tissue characteristics using a method provided to determine myocardial wall dynamics and tissue characteristics using a 3D model of the myocardium. The method comprises generating an epicardial surface and an endocardial surface from a plurality of SAX and LAX slices; identifying a plurality of nodes on the epicardial and endocardial surfaces or in between these surfaces within the myocardium in a reference frame; defining a set of coefficients, each coefficient being associated with the respective location of the corresponding node in a phase; determining the coefficients and in this way determining the model; determining the myocardial wall dynamics in terms of strain values and displacements.

The invention relates to an imaging method and a device for visualizing coronary heart disease, in particular cardiac infarction lesions, in which at least one image of the heart or heart region comprising at least the myocardium is recorded and reproduced using computed tomography part. The method is characterized in that, by windowing the measured data of the image or the data derived therefrom in the region of the myocardium, regions with insufficient blood supply and/or damage are segmented and displayed in the image in a distinctive manner. In particular, the method according to the invention and the associated device can be used to graphically display the extent of damage after a heart attack.

The invention relates to the technical field of a cardioplegic solution, and in particular relates to an autoimmune hemolytic anemia (ALHA) cardioplegic solution and a preparation method thereof. Every 500ml of the ALHA cardioplegic solution contains 552.86-947.76mg of cobamamide, 4.739-5ml of a lidocaine solution of 2% in mass concentration, 30-60mg of pentazocine and 4.1-10ml of a magnesium sulfate solution of 25% in mass concentration. The cardioplegic solution disclosed by the invention can effectively shorten duration of induced cardiac arrest; and the ALHA cardioplegic solution can carry oxygen, so that just few ALHA cardioplegic solution can effectively promote cardiac arrest to avoid hurt of myocardial ischemia reperfusion to cardiac muscle, further improve re-beating success rate in one time and reduce arrhythmia incidence rate after re-beating, and effectively relieve an inflammatory response, so as to effectively protect the cardiac muscle cell.

The invention concerns a data processing apparatus (12) for processing T-wave information (Tl) or ST-segment (ST) information from an electrical signal from a myocardium of a heart of a human or animal, for an assessment of a condition of at least a part of the myocardium or the whole myocardium, characterised in that the data processing apparatus (12) is configured to derive a T-wave deviation value (DV, NDV, 2DV, N2D) from a difference of at least two T-wave parameters (P) or ST-segment parameters (P), wherein each of the two parameters (P) belongs to another T-wave (T) or ST-segment (ST) from the same heart. Further, an assessment apparatus for assessing the condition of at least a part of a myocardium of a heart of an individual human or animal, a method for providing data for an assessment of a condition of at least a part of a myocardium of a heart of a human or an animal, wherein the method includes processing T-wave information from an electrical signal from at least a part ofa myocardium and a diagnosis method for diagnosing a condition or a disease of a heart are proposed. Further, a method for data processing, a method for assessing a condition or a disease of the heartand a diagnosis method are proposed.

A method of determining the amount of intracellular manganese in the myocardium of an individual pre-administered with a manganese contrast agent, or a pharmaceutically acceptable salt thereof, comprising subjecting said individual to a MRI procedure to assess the signal intensity (SI) of images, or more preferably the longitudinal relaxation rate, R1.

The present invention provides a preparation method of a three-dimensional construct for regenerating a cardiac muscle tissue comprising; a step of forming a three-dimensional construct by printing and crosslinking the first bioprinting composition comprising a tissue engineering construct forming solution containing decellularized extracellular matrix and a crosslinking agent, and cardiac progenitor cells, and the second bioprinting composition comprising the tissue engineering construct forming solution, mesenchymal stem cells and a vascular endothelial growth factor, to arrange the first bioprint layer and the second bioprint layer alternately; and a step of obtaining a crosslink-gelated three-dimensional construct by thermally gelating the crosslinked three-dimensional construct, and a three-dimensional construct for regenerating a cardiac muscle tissue, and the preparation method according to the present invention not only equally positions the cardiac progenitor cells in the construct but also implements a vascular network composed of vascular cells in the construct, so that the viability of cells can be maintained for a long time and the cell transfer efficiency into the myocardium can be significantly improved.

The invention provides application of a traditional Chinese medicine composition in preparation of a medicament for treating renal toxicity after chemoradiotherapy and cardiovascular and cerebrovascular diseases. The traditional Chinese medicine composition comprises the components, namely rheum officinale, astragalus membranaceus and root of red-rooted salvia. An experiment proves that the traditional Chinese medicine composition effectively treats and relieves renal toxicity caused by tumor radiation and chemotherapy, and simultaneously has an obvious treatment effect on ischemic cardiovascular and cerebrovascular diseases, for example, cerebellar infarction size is reduced, the cerebral ischemic injury is improved, the infarct size of myocardial ischemia reperfusion in rats is reduced, and the content of methylene dioxyamphetamine (MDA) and NOS is reduced.

The invention provides a locking anchoring device and a transcatheter locking anchoring system. The locking anchoring device comprises an adjusting assembly, a releasing assembly and an anchor, wherein the adjusting assembly comprises a catheter and a stop seat arranged at the far end of the catheter in a protruding mode, the stop seat is provided with a thread inlet groove for a suture to pass through, the anchor is contained at the far end of the stop seat, the far end of the anchor extends out of the stop seat, and the releasing assembly penetrates through the catheter and the stop seat and is detachably connected with the anchor. In the heart intervention process, the anchor can be contracted into the catheter, and the conveying difficulty and the damage to human tissue are reduced; and the depth of the anchor penetrating into the myocardium is limited through the stop seat, and the damage to the tissue is reduced while the anchoring force is guaranteed.

The invention discloses a left ventricle center and a region of interest extraction method, a device adopting the method and a system. According to the left ventricle center and region of the interestextraction method, the device adopting the method and the system, the central position of the left ventricle and the stereoscopic region of interest of myocardium are automatically calculated according to an SPECT cross-sectional image, the central position of the left ventricle and the stereoscopic region of interest of the myocardium are enabled to be distinguished from surrounding tissues andartifacts, a judgment result is enabled not to depend on human experience, the result is accurate, the speed is fast, the calculation speed of myocardial SPECT quantitative indexes is increased, manpower is saved, and efficiency is improved.

A method for direct therapeutic treatment of myocardial tissue in a localized region of a heart having a pathological condition. The method includes identifying at least one target region of the myocardium of the heart to be treated; and injecting a keratin-based material that travels to at least one target region to at least one of stiffen, restrain, or constrain the myocardial tissue of the target region. The material applied results in a physical modification of the mechanical properties, including stiffness, of the infarct tissue. Various devices and modes of practicing the method are disclosed for stiffening, restraining and constraining myocardial tissue for the treatment of conditions including myocardial infarction or mitral valve regurgitation.

The invention discloses a suture-free detachable epicardial temporary pacing lead. The epicardial temporary pacing lead comprises an epicardial electrode end, a connecting wire and a pacemaker connecting end, the epicardial electrode end, the connecting wire and the pacemaker connecting end are connected to form a linear structure, and a biodegradable carrier is arranged on the epicardial electrode end and is adhered to the epicardial through the biodegradable carrier. The pacing wire is composed of an epicardial electrode end, a connecting wire and a pacemaker connecting end. A degradable material is used as an electrode carrier of an epicardial electrode end; the electrode can be pasted and fixed on the epicardium; the electrode is isolated from surrounding tissues while the contact areabetween the electrode and the myocardium is increased, so that the electrode sensing capability is improved, the diaphragm function is prevented from being influenced by electrode discharge, the traditional suture mode for fixing the electrode can be avoided, and the problems of suture bleeding and difficulty in detaching the implanted electrode are solved.

The invention belongs to the technical field of image processing, and discloses an ultrasonic image left ventricular myocardium segmentation method and system and an application. The method comprisesthe steps of obtaining ultrasonic data, dividing the data into a training set, a verification set and a test set, and performing marking; enhancing the diversity of training set samples, interceptingan approximate left ventricular myocardium region, and performing histogram equalization and normalization operation on the data; using Pytorch to realize network segmentation, and storing a model having the best performance on the verification set; and measuring the thickness based on a segmentation result. According to the ultrasonic image left ventricular myocardium segmentation method based ona convolutional neural network, the left ventricular myocardium at the end of diastole can be automatically segmented, shape information of the left ventricular myocardium is added into the network to assist network learning, proposed mixed loss functions are optimized from three angles, and boundary information is further enhanced during learning; and the thickness can be automatically measuredbased on the segmentation result, and no post-processing is needed in the whole process.

The invention provides a high-migration mesenchymal stem cell and a preparation method and application thereof. The preparation method of the high-migration mesenchymal stem cells comprises the following steps: inoculating and suspending mesenchymal stem cells in a mesenchymal stem cell culture solution, carrying out flowing liquid culture in a cell culture rotary bottle or a stirring type fermentation tank without adding a microcarrier in the culture process, collecting cell balls after culture is finished, washing and digesting to form single cells, and obtaining the high-migration mesenchymal stem cells. The prepared high-migration mesenchymal stem cells are small in size, the average diameter is 11-14 microns, the cell surface CXCR4 expression rate reaches up to 30% or above, the cell migration ability is high, the lung retention phenomenon is basically avoided through intravenous injection, and the number of the mesenchymal stem cells reaching ischemic myocardium is remarkably increased.