75 results about "Myocar dial" patented technology

Systems and methods are disclosed for to determining a blood supply and blood demand. One method includes receiving a patient-specific model of vessel geometry of at least a portion of a coronary artery, wherein the model is based on patient-specific image data of at least a portion of a patient's heart having myocardium; determining a coronary blood supply based on the patient-specific model; determining at least a portion of the myocardium corresponding to the coronary artery; determining a myocardial blood demand based on either a mass or a volume of the portion of the myocardium, or based on perfusion imaging of the portion of the myocardium; and determining a relationship between the coronary blood supply and the myocardial blood demand.

A method of describing fluid dynamics in a tissue or organ using a numerical model of blood flow is provided. In one aspect, the invention relates to a method for assessing myocardial perfusion in a human patient using non-invasive measurements and percolation mechanics including computational fluid dynamics. The method may be implemented as a computer-implemented invention. The method includes using patient-specific anatomical structure data obtained from the non-invasive measurements to generate an anatomical geometric model of the myocardium connected to the plurality of coronary vessels. The anatomical geometric model is a combination of fluid and porous domains and boundaries thereof. The invention eliminates the deficiencies of known in vivo methods, including all risks associated with invasive procedures. Furthermore, an actually infinite temporal-spatial resolution is achieved, the result of the invention is completely free of motion artifacts, and the exposure of the patient to radiation is limited.

Devices, systems, and methods for causing retrograde oxygenated blood flow in at least a portion of the venous system of the myocardium are disclosed. Devices and methods include a method for causing retrograde oxygenated blood flow in at least a portion of the venous system of the myocardium, the method comprising: implanting a variable occluder in a coronary sinus region proximate a left atrium, wherein the variable occluder is configured to gradually increase a level of blood flow restriction over a period of days to enable a venous system of the myocardium to compensate for increased pressure caused by the gradual increase in the level of blood flow restriction; and following venous system compensation, shunting oxygenated blood flow into the coronary sinus to cause retrograde flow of oxygenated blood in at least a portion of the venous system of the myocardium to thereby enable revascularization of the myocardium.

The invention discloses a method for non-contact human myocardial contractility detection by using millimeter waves, and relates to the technical field of myocardial contractility detection. The method for performing non-contact human myocardial contractility detection by using millimeter waves comprises the following steps: S1, constructing a millimeter wave radar array and initializing a space model; s2, adaptive adjustment of the dynamic space model; s3, millimeter wave echo signals are collected and preprocessed; s4, high-dimensional signal feature coding and dimension reduction; s5, myocardial contractility index mapping and clinical evaluation; through millimeter wave radar array construction and dynamic adjustment of a space model, non-contact accurate heart monitoring is realized, invasive operation of a traditional technology is avoided, discomfort of a patient is reduced, tiny motion changes of the heart can be captured with high precision, specific algorithm analysis is combined, the contractility of the cardiac muscle can be accurately evaluated, and the cardiac muscle can be accurately monitored. And real-time feedback is provided, and simple and convenient installation and operation can be realized without depending on a high-level technology of an operator.

Systems and methods are disclosed for to determining a blood supply and blood demand. One method includes receiving a patient-specific model of vessel geometry of at least a portion of a coronary artery, wherein the model is based on patient-specific image data of at least a portion of a patient's heart having myocardium; determining a coronary blood supply based on the patient-specific model; determining at least a portion of the myocardium corresponding to the coronary artery; determining a myocardial blood demand based on either a mass or a volume of the portion of the myocardium, or based on perfusion imaging of the portion of the myocardium; and determining a relationship between the coronary blood supply and the myocardial blood demand.

The invention provides an ultrasonic imaging method and an ultrasonic imaging system for a heart, and belongs to the field of ultrasonic imaging. Aiming at the problem that the heart has physiological movement to bring challenge to elastography, the method comprises the following steps: firstly, imaging the heart to obtain an ultrasonic image, then identifying the myocardium from the ultrasonic image and tracking the position of the myocardium (such as a to-be-observed myocardium segment) to obtain the real-time position of the myocardium, and then carrying out elastography on the basis of the real-time position of the myocardium; further, in consideration of the fact that the heart has chamber structures such as an atrium and a ventricle which can affect propagation of shear waves, acoustic radiation force is applied to the to-be-observed cardiac muscle (such as the geometric center or the gravity center) based on the real-time position of the cardiac muscle to generate the shear waves, and therefore the effectiveness of generation of the shear waves and the sufficient signal-to-noise ratio are guaranteed.

The invention provides a processing method and device based on a heart three-dimensional image, equipment and a medium. The processing method comprises the steps of obtaining three-dimensional image data of a heart; performing heart chamber segmentation according to the three-dimensional image data to obtain structure information of each area of the heart; determining the long axis of the left ventricle and the inner diameter and the outer diameter of the cardiac muscle according to the structural information; constructing a three-dimensional mapping of the myocardial wall thickness, and reflecting the form distribution of the myocardium in the space; segmenting the myocardium according to the three-dimensional mapping of the myocardial wall thickness and the long axis to generate segmented region data; and training and outputting a cardiomyopathy classification model through a pre-trained classification model in combination with the segmented region data. According to the method, feature vectors after dimension reduction are utilized to train a cardiomyopathy classification model. By generating a detection report containing an abnormal region position and classification confidence, the method improves the accuracy and efficiency of cardiomyopathy auxiliary detection by fusing image processing, feature extraction and machine learning technologies.

The present application provides a method, device and storage medium for improving the defibrillation energy release accuracy of a defibrillation system. The method includes: obtaining the internal resistance value of the defibrillation system; obtaining the intracardiac impedance value of the patient to be defibrillated; obtaining the defibrillation energy set value input to the defibrillation system; calculating a total defibrillation energy value according to the internal resistance value of the defibrillation system, the intracardiac impedance value of the patient to be defibrillated and the defibrillation energy set value, and charging the charging capacitor of the defibrillation power supply in the defibrillation system with the total defibrillation energy value as the charging target value. The method of the present application can more accurately control the energy released to the patient's myocardium, thereby improving the defibrillation success rate and minimizing the damage to the patient's myocardium caused by defibrillation.

The present invention discloses a biopsy forceps guiding catheter that can be used for zero-ray myocardial biopsy, comprising a catheter body, wherein a central cavity penetrating through both axial ends of the catheter body is provided inside the catheter body, at least one electrode element is provided at the first axial end of the catheter body, an airbag component is provided at the first axial end of the catheter body near the rear side of the electrode element, the electrode element is connected to an electrical connection assembly extending to the second axial end of the catheter body, the electrical connection assembly is connected to an electrocardiogram monitor, and the airbag component is connected to a ventilation assembly extending to the second axial end of the catheter body. The electrocardiogram and injury current in the cardiac cavity are recorded by the electrocardiogram monitor leads to select a site with a significant injury current for sampling, thereby reducing the influence of scars and fat tissue on the quality of the sampled sample, and the airbag component can drift and move with the blood, thereby solving the problem that the current biopsy forceps need to rely on X-ray guidance to be delivered into the ventricle and it is difficult to accurately obtain a specific layer of myocardium under the endocardium during sampling.

The invention provides a hypertrophy myocardial ablation device, which comprises a patch, and is characterized in that an electromagnetic coil is arranged in the patch and is used for generating an electromagnetic field; one end of the connecting piece is fixedly connected with the patch, and the other end of the connecting piece is provided with a hook-shaped structure; and the control assembly controls the intensity and the change frequency of the electromagnetic field generated by the electromagnetic coil. The device has the advantages that non-invasive controllable ablation of hypertrophy myocardium is achieved by integrating the electromagnetic coil, the connecting piece, the control assembly, the electrocardio collecting assembly and the intracardiac pressure collecting assembly, generation and change of an electromagnetic field are accurately controlled by collecting and analyzing heart data in real time, and high efficiency and safety of treatment are guaranteed.

A non-invasive method for cardiac arrhythmia risk stratification may include identifying, based at least on an electrical recording of a patient, a cardiac depolarization simulation and a cardiac repolarization simulation corresponding to an electrical recording of a patient. One or more regions of increased spatial repolarization gradient in which a first area of a myocardium of the patient exhibits a first repolarization rate that differs from a second repolarization rate of a second area of the myocardium by an amount then divided by the spatial distance between the two regions, by a threshold value may be determined based on the cardiac depolarization simulation and the cardiac repolarization simulation. A risk of cardiac arrhythmia for the patient may be determined based a magnitude of the increased spatial repolarization gradient. Moreover, a treatment plan for the patient may be determined based on the magnitude and / or location of the increased spatial repolarization gradient.

The invention provides a medical image processing apparatus and an X-ray diagnostic apparatus, which can quantitatively measure blood flow without using a sensor line during INOCA examination. The medical image processing apparatus includes a processing circuit. The processing circuit acquires a zeroth contrast image when the heart of a subject is in a reference state, a first contrast image when the heart is in an acetylcholine-loaded state, and a second contrast image when the heart is in an adenosine-loaded state. The processing circuit calculates, on the basis of the zeroth contrast image and the first contrast image, a first blood flow ratio indicating the ratio of a zeroth blood flow rate of the cardiac muscle in a reference state to a first blood flow rate of the cardiac muscle in an acetylcholine-loaded state. On the basis of the zeroth contrast image and the second contrast image, the processing circuit calculates a second blood flow ratio indicating the ratio of the zeroth blood flow to a second blood flow of the cardiac muscle in an adenosine-loaded state. The processing circuit displays the first blood flow ratio and the second blood flow ratio on the display in parallel.

The present invention relates to a myocardial spectroscopy probe comprising: at least two separate light guides (120A, 120B) insertable into tissue, wherein a first light guide (120A, 120B) is configured to deliver light, a second light guide (120A, 120B) is configured to collect light, and the first light guide (120A, 120B) and the second light guide (120A, 120B) are arranged to be distinguished from each other.

The invention relates to a traditional Chinese medicine composition for treating myocardial ischemia-reperfusion injury and a preparation method thereof, and belongs to the technical field of traditional Chinese medicine compositions. In order to solve the problem that a traditional Chinese medicine compound for treating myocardial ischemia-reperfusion injury is lacked in the prior art, the invention provides a traditional Chinese medicine composition for treating myocardial ischemia-reperfusion injury, and the traditional Chinese medicine composition comprises American ginseng, astragalus membranaceus, radix ophiopogonis, schisandra chinensis, radix rehmanniae recen, salvia miltiorrhiza, radix sophorae flavescentis, radix scrophulariae, honeysuckle, fructus forsythiae and liquorice. The traditional Chinese medicine composition provided by the invention has the effects of promoting blood circulation to remove blood stasis, reinforcing qi and nourishing yin, and activating meridians to stop pain, and is beneficial to improving the microcirculation state of cardiac muscle and relieving inflammatory response of cardiac muscle, so that damaged cardiac muscle tissues are protected. Animal experiments prove that the traditional Chinese medicine composition can effectively reduce the myocardial infarction area of MIRI model rats, remarkably improve the activity of myocardial cells subjected to hypoxia-reoxygenation injury and reduce the apoptosis rate of the myocardial cells subjected to hypoxia-reoxygenation injury. The invention provides a new way for clinical multi-target treatment of myocardial ischemia reperfusion injury.

The invention provides a method and device for improving defibrillation energy release precision of a defibrillation system and a storage medium. The method comprises the following steps: acquiring an internal resistance value of the defibrillation system; acquiring an intracardiac impedance value of the patient to be defibrillated; acquiring a defibrillation energy set value input to the defibrillation system; and calculating a total defibrillation energy value according to the internal resistance value of the defibrillation system, the intracardiac impedance value of the patient to be defibrillated and the defibrillation energy set value, and charging a charging capacitor of a defibrillation power supply in the defibrillation system by taking the total defibrillation energy value as a charging target value. According to the method, the energy released to the cardiac muscle of the patient can be more accurately controlled, so that the defibrillation success rate is improved, and the damage of defibrillation to the cardiac muscle of the patient is reduced as much as possible.

The present invention belongs to the technical field of pulsed electric field ablation for hypertrophic cardiomyopathy, and specifically relates to a pulsed electric field ablation device for hypertrophic cardiomyopathy. The device comprises a pulse generator (1). A flexible catheter (2) is fixedly mounted on one side of the pulse generator (1), and a slidably connected sliding member (3) is arranged on the outer surface of the flexible catheter (2). By means of the arrangement of an auxiliary ablation assembly (6), a real-time three-dimensional echocardiography can be generated during the ablation process, and a relatively clear cardiac structure image can be provided for a doctor by means of the three-dimensional echocardiography, such that the doctor can better determine the region of hypertrophied myocardium. Moreover, data analysis is performed on the hearts of a large number of patients by means of artificial intelligence and a machine learning algorithm inside a high-speed analog-to-digital converter to generate a personalized cardiac model, so as to assist the doctor in accurate positioning, thereby reducing the number of times of adjusting the position of a PFAD electrode catheter, shortening the time required by the doctor during surgery, and reducing the difficulty of surgery treatment.

The invention discloses a processing method and device based on a heart three-dimensional image, equipment and a medium. The method comprises the following steps: acquiring a heart three-dimensional image and a chamber segmentation result to obtain a left ventricular heart cavity and a cardiac muscle; according to the inner diameter and the outer diameter of the myocardial, constructing a three-dimensional inner diameter curved surface and generating myocardial wall thickness mapping; determining a pre-trained classification model and constructing two-channel input of the classification model; inputting the curved surface and the mapping into a first channel of a model, and combining whole heart segmentation or original image data of a second channel; and processing dual-channel input through the model, and outputting a cardiomyopathy classification result. According to the method, a complete spatial form is reserved through the three-dimensional inner diameter curved surface and wall thickness mapping, and precise and robust classification of various cardiomyopathy such as hypertrophic cardiomyopathy and dilated cardiomyopathy is realized by combining dual-channel feature fusion and interactive calibration of a space guidance mask; the problems of efficiently and accurately extracting features from a complex three-dimensional heart image and automatically identifying diseases are solved.

The invention provides an image processing method and device, a storage medium and electronic equipment. The method comprises the following steps: acquiring a coronary CT contrast image of a target object; coronary blood vessels and myocardium in the coronary CT contrast image are recognized, and the blood supply relation between the coronary blood vessels and the myocardium is determined; generating a heart three-dimensional model according to the coronary vessels and the myocardium; and displaying myocardial blood supply areas with blood supply relations corresponding to different target blood vessel points on coronary blood vessels of the heart three-dimensional model. By determining the blood supply relation between the coronary blood vessels and the myocardium in the coronary CT contrast image, the myocardial blood supply area with the blood supply relation corresponding to the target blood vessel point is displayed in the heart three-dimensional model corresponding to the coronary CT contrast image, and analysis and visual display of the blood supply relation between the coronary blood vessels and the myocardium are achieved. The position and size of the myocardial blood supply area corresponding to the target blood vessel point are visually displayed, and the influence degree of the target blood vessel point on the myocardial is visually displayed.

The embodiment of the invention discloses a three-dimensional myocardial scar visualization system. According to one specific embodiment, the system comprises a data processing end configured to perform heart structure and scar segmentation on target heart magnetic resonance data to obtain a binary tag graph for the heart and the myocardium; constructing an individualized ventricular network and a scar three-dimensional surface model based on the binary label graph; generating an initial myocardial scar three-dimensional model; generating lead implantation track information; generating a myocardial scar three-dimensional model according to the lead implantation track information; and the model application end is configured to perform model rendering on a target application page according to the model parameters corresponding to the myocardial scar three-dimensional model sent by the data processing end so as to provide an interactive operation function and generate a clinical report. According to the embodiment, accurate and visual three-dimensional visual decision support can be provided for preoperative planning and intraoperative navigation of heart diseases, so that the accuracy of surgical planning and the clinical working efficiency are remarkably improved.

The present application relates to the field of food, health care products and medicine, and specifically relates to a purslane oral composition for regulating blood lipid and resisting atherosclerosis, and a preparation method and application thereof. The present application takes purslane extract, galangal extract and borneol as core components, and realizes the synergistic effects of lipid regulation, anti-inflammation, reduction of plaque area, stabilization of vulnerable plaque, mild anti-thrombus and myocardial protection through scientific proportioning. The bioavailability is significantly improved by combining the tongue sublingual absorption of borneol and the mucosal penetration of galangal volatile oil. The composition has comprehensive targets, definite effects and good safety, and can be made into oral dosage forms such as buccal tablets, dripping pills and oral disintegrating tablets, and is suitable for daily oral care of cardiovascular sub-healthy people.

The invention discloses a cardiac magnetic resonance T1mapping image synthesis method, which comprises the following steps of: acquiring a plurality of groups of samples, each group comprising native T1mapping images and movie imaging sequence images, determining a heart region corresponding to each native T1mapping image, identifying initial associated image pairs of end diastole and end systole from the same group of movie images according to the heart region corresponding to each native T1mapping image, and synthesizing the initial associated image pairs of the end diastole and end systole according to the initial associated image pairs of the end diastole and end systole. Obtaining a target associated image pair corresponding to the heart preset region after segmentation, and training the constructed initial diffusion model to obtain a target model; respectively extracting myocardial tissue texture features and heart morphological dynamic features in a specific period from each film imaging sequence image; and inputting the tissue texture features and the heart morphological dynamic features into a target model, and performing inverse diffusion denoising on random noise randomly sampled from Gaussian distribution to obtain a synthesized T1mapping image. According to the method, rapid, efficient and high-quality T1mapping image synthesis can be realized.

The present invention discloses a multifunctional myocardial excision knife, belonging to the field of medical equipment technology. The knife comprises a front end that is generally arc-shaped, with two sides that are concave inward with a certain curvature, forming a three-sided blade structure. The rear end of the knife is provided with an opening that forms a channel for the excised myocardial tissue to be discharged. A cover plate is provided on the top of the knife. A handle is connected to the cover plate for controlling the knife. The knife can be rotated to achieve cutting in different directions. The knife is equipped with an endoscope for observing the myocardium at the cutting site. This invention helps improve surgical efficiency, reduce surgical risks and difficulty, and alleviate the workload of medical staff.

The present invention relates to a myocardial spectrometer probe comprising at least two separate light guides (120A, 120B) insertable into tissue, wherein a first light guide (120A, 120B) is arranged to deliver light and a second light guide (120A, 120B) is arranged to collect light, and wherein the first light guide (120A, 120B) and the second light guide (120A, 120B) are arranged separately from each other.

Various systems and methods are provided for electrocardiogram radial depth navigation to insert an intracardiac device into the heart. In one example, a method includes, during insertion of an intracardiac device into a muscle or chamber of a heart, acquiring an intracardiac electrogram signal by an electrode of the intracardiac device, and outputting a radial depth indication relative to a myocardium of the heart based on electronic processing of the intracardiac electrogram signal.

This invention discloses an automatic identification and classification method for scarred myocardium based on cine magnetic resonance imaging (CMRI) and deep learning. After preprocessing cardiac cMRI images, the method extracts the relative motion and imaging features of the left ventricular myocardium. A multimodal feature fusion network is then used for training and prediction to identify and classify five different types of scarred myocardium. The extraction of relative motion and imaging features enables an accurate and detailed description of the state of scarred myocardium. The multimodal feature fusion network model captures the compensatory effects of long-distance scarred myocardium movement, the non-rigid deformation motion patterns of the myocardium, and the spatiotemporal relationship between myocardial motion and morphology. This invention achieves high efficiency and accuracy in identifying and classifying scarred myocardium, saving doctors time and effort in diagnosing cardiovascular diseases leading to scarred myocardium, reducing patient suffering, and facilitating a more stable and simpler examination and diagnostic method.

Various configurations of systems that employ leadless electrodes to provide pacing therapy are provided. In one example, a system that provides multiple sites for pacing of myocardium of a heart includes wireless pacing electrode assemblies that are implantable at sites proximate the myocardium using a percutaneous, transluminal, catheter delivery system. Also disclosed are various configurations of such systems, wireless electrode assemblies, and delivery catheters for delivering and implanting the electrode assemblies.

The invention relates to the technical field of data processing, in particular to a target classification method and device based on image recognition and a storage medium. Comprising the following steps: acquiring at least two frames of to-be-recognized images including the cardiac muscle of the same to-be-detected subject; determining time sequence features and spatial features of the to-be-recognized image; the time sequence features are used for representing the time sequence of at least two frames of to-be-recognized images, and the spatial features are used for representing the myocardial distribution condition in each frame of to-be-recognized image; and determining the probability that the at least two frames of to-be-identified images belong to the target classification according to the time sequence features and the spatial features. The embodiment of the invention is used for solving the problem that the current image classification recognition mode consumes long time.

Ischemic heart disease is a leading cause of death and reduced quality of life worldwide. Although revascularization strategies significantly reduce mortality after acute myocardial infarction (MI), many patients with MI develop chronic heart failure over time. We previously reported that human recombinant ANGPTL4 counteracts ischemia-induced vascular endothelial growth factor signaling and disruption of endothelial cell-cell adhesion, thereby inhibiting vascular permeability. We were able to demonstrate that ANGPTL4 administration before MI resulted in protection of the coronary capillary network, no-reflow syndrome, and reduced infarct size in mice. We also demonstrated that the therapeutic effects observed with ANGPTL4 under ischemic conditions were caused by the FLD fragment, not the CCD fragment (WO 2016 / 110498). To further examine the therapeutic potential of the FLD fragment of ANGPTL4 at the onset of reperfusion, we herein used a porcine model, a clinically relevant model of acute myocardial infarction that can be easily and safely translated into patient treatment. We demonstrated that local (antegrade) delivery of the FLD ANGPTL4 to infarcted porcine hearts can efficiently target the lesion site in a clinically relevant manner. A single administration of the FLD of ANGPTL4 improved cardiac function, infarct size, fibrosis, and adverse remodeling parameters 28 days after MI. Short-term MI experiments, coupled with complementary mouse studies, demonstrated myocardial protection. Thus, a single administration of the FLD of ANGPTL4 can reduce ischemia-reperfusion injury and protect against adverse postischemic cardiac remodeling and subsequent ischemic heart failure.

The invention relates to a myocardial progenitor cell and drug double-loaded hydrogel biological material and application thereof, and particularly provides a biological material compound which comprises an organic compound, living cells and a loading material, and the organic compound can induce expression of protease. The compound is used in the treatment process of myocardial infarction (MI), the functionality of transplanted cells is improved, and effective repair and functional recovery of damaged myocardium are promoted.

The present invention provides a method and a system for ultrasonic imaging of the heart, belonging to the field of ultrasonic imaging. In view of the problem that the physiological movement of the heart itself poses challenges to elastography, the heart is first imaged to obtain an ultrasonic image, and then the myocardium is identified from the ultrasonic image and the position of the myocardium (such as the myocardial segment to be observed) is tracked to obtain the real-time position of the myocardium. On this basis, elastography is carried out. Further, considering that the chamber structures such as the atrium and ventricle of the heart will affect the propagation of shear waves, acoustic radiation force is applied to the myocardium to be observed (such as its geometric center or center of gravity) based on the real-time position of the myocardium to generate shear waves, so as to ensure the effectiveness of shear wave generation and sufficient signal-to-noise ratio.