50 results about "Myocar dial" patented technology

Devices, systems, and methods for causing retrograde oxygenated blood flow in at least a portion of the venous system of the myocardium are disclosed. Devices and methods include a method for causing retrograde oxygenated blood flow in at least a portion of the venous system of the myocardium, the method comprising: implanting a variable occluder in a coronary sinus region proximate a left atrium, wherein the variable occluder is configured to gradually increase a level of blood flow restriction over a period of days to enable a venous system of the myocardium to compensate for increased pressure caused by the gradual increase in the level of blood flow restriction; and following venous system compensation, shunting oxygenated blood flow into the coronary sinus to cause retrograde flow of oxygenated blood in at least a portion of the venous system of the myocardium to thereby enable revascularization of the myocardium.

The invention discloses a method for non-contact human myocardial contractility detection by using millimeter waves, and relates to the technical field of myocardial contractility detection. The method for performing non-contact human myocardial contractility detection by using millimeter waves comprises the following steps: S1, constructing a millimeter wave radar array and initializing a space model; s2, adaptive adjustment of the dynamic space model; s3, millimeter wave echo signals are collected and preprocessed; s4, high-dimensional signal feature coding and dimension reduction; s5, myocardial contractility index mapping and clinical evaluation; through millimeter wave radar array construction and dynamic adjustment of a space model, non-contact accurate heart monitoring is realized, invasive operation of a traditional technology is avoided, discomfort of a patient is reduced, tiny motion changes of the heart can be captured with high precision, specific algorithm analysis is combined, the contractility of the cardiac muscle can be accurately evaluated, and the cardiac muscle can be accurately monitored. And real-time feedback is provided, and simple and convenient installation and operation can be realized without depending on a high-level technology of an operator.

Systems and methods are disclosed for to determining a blood supply and blood demand. One method includes receiving a patient-specific model of vessel geometry of at least a portion of a coronary artery, wherein the model is based on patient-specific image data of at least a portion of a patient's heart having myocardium; determining a coronary blood supply based on the patient-specific model; determining at least a portion of the myocardium corresponding to the coronary artery; determining a myocardial blood demand based on either a mass or a volume of the portion of the myocardium, or based on perfusion imaging of the portion of the myocardium; and determining a relationship between the coronary blood supply and the myocardial blood demand.

The invention provides a processing method and device based on a heart three-dimensional image, equipment and a medium. The processing method comprises the steps of obtaining three-dimensional image data of a heart; performing heart chamber segmentation according to the three-dimensional image data to obtain structure information of each area of the heart; determining the long axis of the left ventricle and the inner diameter and the outer diameter of the cardiac muscle according to the structural information; constructing a three-dimensional mapping of the myocardial wall thickness, and reflecting the form distribution of the myocardium in the space; segmenting the myocardium according to the three-dimensional mapping of the myocardial wall thickness and the long axis to generate segmented region data; and training and outputting a cardiomyopathy classification model through a pre-trained classification model in combination with the segmented region data. According to the method, feature vectors after dimension reduction are utilized to train a cardiomyopathy classification model. By generating a detection report containing an abnormal region position and classification confidence, the method improves the accuracy and efficiency of cardiomyopathy auxiliary detection by fusing image processing, feature extraction and machine learning technologies.

The present application provides a method, device and storage medium for improving the defibrillation energy release accuracy of a defibrillation system. The method includes: obtaining the internal resistance value of the defibrillation system; obtaining the intracardiac impedance value of the patient to be defibrillated; obtaining the defibrillation energy set value input to the defibrillation system; calculating a total defibrillation energy value according to the internal resistance value of the defibrillation system, the intracardiac impedance value of the patient to be defibrillated and the defibrillation energy set value, and charging the charging capacitor of the defibrillation power supply in the defibrillation system with the total defibrillation energy value as the charging target value. The method of the present application can more accurately control the energy released to the patient's myocardium, thereby improving the defibrillation success rate and minimizing the damage to the patient's myocardium caused by defibrillation.

The present invention discloses a biopsy forceps guiding catheter that can be used for zero-ray myocardial biopsy, comprising a catheter body, wherein a central cavity penetrating through both axial ends of the catheter body is provided inside the catheter body, at least one electrode element is provided at the first axial end of the catheter body, an airbag component is provided at the first axial end of the catheter body near the rear side of the electrode element, the electrode element is connected to an electrical connection assembly extending to the second axial end of the catheter body, the electrical connection assembly is connected to an electrocardiogram monitor, and the airbag component is connected to a ventilation assembly extending to the second axial end of the catheter body. The electrocardiogram and injury current in the cardiac cavity are recorded by the electrocardiogram monitor leads to select a site with a significant injury current for sampling, thereby reducing the influence of scars and fat tissue on the quality of the sampled sample, and the airbag component can drift and move with the blood, thereby solving the problem that the current biopsy forceps need to rely on X-ray guidance to be delivered into the ventricle and it is difficult to accurately obtain a specific layer of myocardium under the endocardium during sampling.

The invention provides a hypertrophy myocardial ablation device, which comprises a patch, and is characterized in that an electromagnetic coil is arranged in the patch and is used for generating an electromagnetic field; one end of the connecting piece is fixedly connected with the patch, and the other end of the connecting piece is provided with a hook-shaped structure; and the control assembly controls the intensity and the change frequency of the electromagnetic field generated by the electromagnetic coil. The device has the advantages that non-invasive controllable ablation of hypertrophy myocardium is achieved by integrating the electromagnetic coil, the connecting piece, the control assembly, the electrocardio collecting assembly and the intracardiac pressure collecting assembly, generation and change of an electromagnetic field are accurately controlled by collecting and analyzing heart data in real time, and high efficiency and safety of treatment are guaranteed.

A non-invasive method for cardiac arrhythmia risk stratification may include identifying, based at least on an electrical recording of a patient, a cardiac depolarization simulation and a cardiac repolarization simulation corresponding to an electrical recording of a patient. One or more regions of increased spatial repolarization gradient in which a first area of a myocardium of the patient exhibits a first repolarization rate that differs from a second repolarization rate of a second area of the myocardium by an amount then divided by the spatial distance between the two regions, by a threshold value may be determined based on the cardiac depolarization simulation and the cardiac repolarization simulation. A risk of cardiac arrhythmia for the patient may be determined based a magnitude of the increased spatial repolarization gradient. Moreover, a treatment plan for the patient may be determined based on the magnitude and / or location of the increased spatial repolarization gradient.

The invention provides a medical image processing apparatus and an X-ray diagnostic apparatus, which can quantitatively measure blood flow without using a sensor line during INOCA examination. The medical image processing apparatus includes a processing circuit. The processing circuit acquires a zeroth contrast image when the heart of a subject is in a reference state, a first contrast image when the heart is in an acetylcholine-loaded state, and a second contrast image when the heart is in an adenosine-loaded state. The processing circuit calculates, on the basis of the zeroth contrast image and the first contrast image, a first blood flow ratio indicating the ratio of a zeroth blood flow rate of the cardiac muscle in a reference state to a first blood flow rate of the cardiac muscle in an acetylcholine-loaded state. On the basis of the zeroth contrast image and the second contrast image, the processing circuit calculates a second blood flow ratio indicating the ratio of the zeroth blood flow to a second blood flow of the cardiac muscle in an adenosine-loaded state. The processing circuit displays the first blood flow ratio and the second blood flow ratio on the display in parallel.

The present invention belongs to the technical field of pulsed electric field ablation for hypertrophic cardiomyopathy, and specifically relates to a pulsed electric field ablation device for hypertrophic cardiomyopathy. The device comprises a pulse generator (1). A flexible catheter (2) is fixedly mounted on one side of the pulse generator (1), and a slidably connected sliding member (3) is arranged on the outer surface of the flexible catheter (2). By means of the arrangement of an auxiliary ablation assembly (6), a real-time three-dimensional echocardiography can be generated during the ablation process, and a relatively clear cardiac structure image can be provided for a doctor by means of the three-dimensional echocardiography, such that the doctor can better determine the region of hypertrophied myocardium. Moreover, data analysis is performed on the hearts of a large number of patients by means of artificial intelligence and a machine learning algorithm inside a high-speed analog-to-digital converter to generate a personalized cardiac model, so as to assist the doctor in accurate positioning, thereby reducing the number of times of adjusting the position of a PFAD electrode catheter, shortening the time required by the doctor during surgery, and reducing the difficulty of surgery treatment.

The invention discloses a processing method and device based on a heart three-dimensional image, equipment and a medium. The method comprises the following steps: acquiring a heart three-dimensional image and a chamber segmentation result to obtain a left ventricular heart cavity and a cardiac muscle; according to the inner diameter and the outer diameter of the myocardial, constructing a three-dimensional inner diameter curved surface and generating myocardial wall thickness mapping; determining a pre-trained classification model and constructing two-channel input of the classification model; inputting the curved surface and the mapping into a first channel of a model, and combining whole heart segmentation or original image data of a second channel; and processing dual-channel input through the model, and outputting a cardiomyopathy classification result. According to the method, a complete spatial form is reserved through the three-dimensional inner diameter curved surface and wall thickness mapping, and precise and robust classification of various cardiomyopathy such as hypertrophic cardiomyopathy and dilated cardiomyopathy is realized by combining dual-channel feature fusion and interactive calibration of a space guidance mask; the problems of efficiently and accurately extracting features from a complex three-dimensional heart image and automatically identifying diseases are solved.

The invention provides an image processing method and device, a storage medium and electronic equipment. The method comprises the following steps: acquiring a coronary CT contrast image of a target object; coronary blood vessels and myocardium in the coronary CT contrast image are recognized, and the blood supply relation between the coronary blood vessels and the myocardium is determined; generating a heart three-dimensional model according to the coronary vessels and the myocardium; and displaying myocardial blood supply areas with blood supply relations corresponding to different target blood vessel points on coronary blood vessels of the heart three-dimensional model. By determining the blood supply relation between the coronary blood vessels and the myocardium in the coronary CT contrast image, the myocardial blood supply area with the blood supply relation corresponding to the target blood vessel point is displayed in the heart three-dimensional model corresponding to the coronary CT contrast image, and analysis and visual display of the blood supply relation between the coronary blood vessels and the myocardium are achieved. The position and size of the myocardial blood supply area corresponding to the target blood vessel point are visually displayed, and the influence degree of the target blood vessel point on the myocardial is visually displayed.

The embodiment of the invention discloses a three-dimensional myocardial scar visualization system. According to one specific embodiment, the system comprises a data processing end configured to perform heart structure and scar segmentation on target heart magnetic resonance data to obtain a binary tag graph for the heart and the myocardium; constructing an individualized ventricular network and a scar three-dimensional surface model based on the binary label graph; generating an initial myocardial scar three-dimensional model; generating lead implantation track information; generating a myocardial scar three-dimensional model according to the lead implantation track information; and the model application end is configured to perform model rendering on a target application page according to the model parameters corresponding to the myocardial scar three-dimensional model sent by the data processing end so as to provide an interactive operation function and generate a clinical report. According to the embodiment, accurate and visual three-dimensional visual decision support can be provided for preoperative planning and intraoperative navigation of heart diseases, so that the accuracy of surgical planning and the clinical working efficiency are remarkably improved.

The present application relates to the field of food, health care products and medicine, and specifically relates to a purslane oral composition for regulating blood lipid and resisting atherosclerosis, and a preparation method and application thereof. The present application takes purslane extract, galangal extract and borneol as core components, and realizes the synergistic effects of lipid regulation, anti-inflammation, reduction of plaque area, stabilization of vulnerable plaque, mild anti-thrombus and myocardial protection through scientific proportioning. The bioavailability is significantly improved by combining the tongue sublingual absorption of borneol and the mucosal penetration of galangal volatile oil. The composition has comprehensive targets, definite effects and good safety, and can be made into oral dosage forms such as buccal tablets, dripping pills and oral disintegrating tablets, and is suitable for daily oral care of cardiovascular sub-healthy people.

The invention discloses a cardiac magnetic resonance T1mapping image synthesis method, which comprises the following steps of: acquiring a plurality of groups of samples, each group comprising native T1mapping images and movie imaging sequence images, determining a heart region corresponding to each native T1mapping image, identifying initial associated image pairs of end diastole and end systole from the same group of movie images according to the heart region corresponding to each native T1mapping image, and synthesizing the initial associated image pairs of the end diastole and end systole according to the initial associated image pairs of the end diastole and end systole. Obtaining a target associated image pair corresponding to the heart preset region after segmentation, and training the constructed initial diffusion model to obtain a target model; respectively extracting myocardial tissue texture features and heart morphological dynamic features in a specific period from each film imaging sequence image; and inputting the tissue texture features and the heart morphological dynamic features into a target model, and performing inverse diffusion denoising on random noise randomly sampled from Gaussian distribution to obtain a synthesized T1mapping image. According to the method, rapid, efficient and high-quality T1mapping image synthesis can be realized.

The present invention discloses a multifunctional myocardial excision knife, belonging to the field of medical equipment technology. The knife comprises a front end that is generally arc-shaped, with two sides that are concave inward with a certain curvature, forming a three-sided blade structure. The rear end of the knife is provided with an opening that forms a channel for the excised myocardial tissue to be discharged. A cover plate is provided on the top of the knife. A handle is connected to the cover plate for controlling the knife. The knife can be rotated to achieve cutting in different directions. The knife is equipped with an endoscope for observing the myocardium at the cutting site. This invention helps improve surgical efficiency, reduce surgical risks and difficulty, and alleviate the workload of medical staff.

The present invention relates to a myocardial spectrometer probe comprising at least two separate light guides (120A, 120B) insertable into tissue, wherein a first light guide (120A, 120B) is arranged to deliver light and a second light guide (120A, 120B) is arranged to collect light, and wherein the first light guide (120A, 120B) and the second light guide (120A, 120B) are arranged separately from each other.

This invention discloses an automatic identification and classification method for scarred myocardium based on cine magnetic resonance imaging (CMRI) and deep learning. After preprocessing cardiac cMRI images, the method extracts the relative motion and imaging features of the left ventricular myocardium. A multimodal feature fusion network is then used for training and prediction to identify and classify five different types of scarred myocardium. The extraction of relative motion and imaging features enables an accurate and detailed description of the state of scarred myocardium. The multimodal feature fusion network model captures the compensatory effects of long-distance scarred myocardium movement, the non-rigid deformation motion patterns of the myocardium, and the spatiotemporal relationship between myocardial motion and morphology. This invention achieves high efficiency and accuracy in identifying and classifying scarred myocardium, saving doctors time and effort in diagnosing cardiovascular diseases leading to scarred myocardium, reducing patient suffering, and facilitating a more stable and simpler examination and diagnostic method.

Various configurations of systems that employ leadless electrodes to provide pacing therapy are provided. In one example, a system that provides multiple sites for pacing of myocardium of a heart includes wireless pacing electrode assemblies that are implantable at sites proximate the myocardium using a percutaneous, transluminal, catheter delivery system. Also disclosed are various configurations of such systems, wireless electrode assemblies, and delivery catheters for delivering and implanting the electrode assemblies.

Ischemic heart disease is a leading cause of death and reduced quality of life worldwide. Although revascularization strategies significantly reduce mortality after acute myocardial infarction (MI), many patients with MI develop chronic heart failure over time. We previously reported that human recombinant ANGPTL4 counteracts ischemia-induced vascular endothelial growth factor signaling and disruption of endothelial cell-cell adhesion, thereby inhibiting vascular permeability. We were able to demonstrate that ANGPTL4 administration before MI resulted in protection of the coronary capillary network, no-reflow syndrome, and reduced infarct size in mice. We also demonstrated that the therapeutic effects observed with ANGPTL4 under ischemic conditions were caused by the FLD fragment, not the CCD fragment (WO 2016 / 110498). To further examine the therapeutic potential of the FLD fragment of ANGPTL4 at the onset of reperfusion, we herein used a porcine model, a clinically relevant model of acute myocardial infarction that can be easily and safely translated into patient treatment. We demonstrated that local (antegrade) delivery of the FLD ANGPTL4 to infarcted porcine hearts can efficiently target the lesion site in a clinically relevant manner. A single administration of the FLD of ANGPTL4 improved cardiac function, infarct size, fibrosis, and adverse remodeling parameters 28 days after MI. Short-term MI experiments, coupled with complementary mouse studies, demonstrated myocardial protection. Thus, a single administration of the FLD of ANGPTL4 can reduce ischemia-reperfusion injury and protect against adverse postischemic cardiac remodeling and subsequent ischemic heart failure.

The invention relates to a myocardial progenitor cell and drug double-loaded hydrogel biological material and application thereof, and particularly provides a biological material compound which comprises an organic compound, living cells and a loading material, and the organic compound can induce expression of protease. The compound is used in the treatment process of myocardial infarction (MI), the functionality of transplanted cells is improved, and effective repair and functional recovery of damaged myocardium are promoted.

The invention relates to the technical field of medical instruments, in particular to an electrocardiosignal acquisition structure of myocardial biopsy forceps. Comprising a sleeve; the tail end of the sleeve is fixedly connected to the control seat; the telescopic movable pipe is connected into the sleeve in a sliding manner; the push-and-pull sliding piece is connected to the control base in a sliding mode, and the tail end of the telescopic movable pipe is fixedly connected to the push-and-pull sliding piece; the conductor wire comprises a first conductor wire, a second conductor wire and an insulating sleeve which wraps the first conductor wire and the second conductor wire and enables the first conductor wire and the second conductor wire to be insulated from each other; the tail end of the electric lead penetrates through the push-pull sliding sleeve to be connected to the tail end of the control base. And the like; by improving an electrocardiosignal acquisition structure of the pair of myocardial biopsy forceps, the pair of myocardial biopsy forceps can more accurately locate the position of a diseased myocardial, and the position of clamping the myocardial is prevented from deviating.

A method for segmentation of a cardiac myocardium in one or more images of a subject includes receiving at least one image of a heart of the subject, a segmentation of at least one heart structure, and an identification of a right ventricle insertion point, providing the at least one image of a heart of the subject, the segmentation of the at least one heart structure, and the identification of a right ventricle insertion point to a segmentation model, and generating, using the segmentation model, a subject specific seventeen segment myocardial contour model.

A cardiac angiography analysis method, an angiography data processing method and an ultrasonic imaging device, the method comprising: when the heart of a target object is in a resting state, injecting a contrast agent to the heart of the target object, emitting a first ultrasonic wave to the heart containing contrast agent microbubbles, and generating a first angiography image; acquiring a first myocardial angiography parameter of the myocardial region of interest as a resting parameter based on the first angiography image; when the heart of the target object is in the load state, a contrast agent is injected into the heart of the target object, second ultrasonic waves are emitted to the heart containing contrast agent microbubbles, and a second contrast image is generated; acquiring a second myocardial angiography parameter of the myocardial region-of-interest as a load parameter based on the second angiography image; and determining reserve parameters of the myocardial region of interest based on the resting parameters and the load parameters, and outputting the reserve parameters or information reflecting the reserve parameters. According to the method, the reserve function and dynamic change of the myocardium can be accurately evaluated.

The signal analysis device comprises: a biological information acquisition unit, which acquires a waveform of a time interval of an R wave included in a waveform representing one cardiac cycle of a heart to be analyzed as an object time waveform; and an analysis unit, which acquires, as a parameter representing the activity of the myocardium of the heart, at least any one of at least a portion of the parameters of a first unimodal distribution, at least a portion of the parameters of a first cumulative distribution function, at least a portion of the parameters of a second unimodal distribution, and at least a portion of the parameters of a second cumulative distribution function when approximating the object time waveform by a time waveform generated by a difference or a weighted difference between a first cumulative distribution function and a second cumulative distribution function, or a time waveform generated by adding a level value to the difference or a weighted difference between the first cumulative distribution function and the second cumulative distribution function, i.e., an approximate time waveform.

The application provides use of tenascin C in preparation of a drug for promoting controllable regeneration of myocardium or myocardial repair. The application also provides a heart patch containing tenascin C. The application further provides a preparation method of the heart patch. The application also provides use of the heart patch in preparation of a drug for preventing controllable regeneration or myocardial repair. The method of the application can improve the safety of myocardial regeneration and avoid the burden on the body caused by excessive enlargement of the heart.

The invention discloses a preparation method of heart failure treatment hydrogel with tissue repair and electric signal conduction functions, and relates to the technical field of medical materials. The preparation method comprises the following steps: S1, dissolving natural polysaccharide molecules with amino groups in water to obtain a solution A; s2, dissolving a micromolecular cross-linking agent with an aldehyde group in water to obtain a solution B; s3, performing sulfation modification on the natural macromolecules, performing oxidative polymerization on EDOT monomers and the sulfated natural macromolecules, and dissolving in water to obtain a solution C; s4, culturing stem cells, separating, purifying and freeze-drying to obtain freeze-dried powder of a stem cell secretion group, and dissolving the freeze-dried powder in water to obtain a solution D; s5, mixing the solution A, the solution B, the solution C and the solution D to obtain the hydrogel for treating the heart failure. The hydrogel disclosed by the invention has good biocompatibility under physiological conditions, can be effectively matched with the conductivity of natural myocardium, and promotes angiogenesis in an injured area, so that the purpose of repairing heart injury is achieved.

The invention relates to the technical field of myocardial biopsy, in particular to a myocardial biopsy sampling device, system and method based on a CSP delivery sheath, and the device comprises a pair of myocardial biopsy forceps and the CSP delivery sheath which is used for guiding the myocardial biopsy forceps to move to the inner wall of the myocardial and is in vertical contact with the inner wall of the myocardial; placing the CSP delivery sheath into the body of the patient by taking the axillary vein as a placing path until the extending end of the CSP delivery sheath is vertically positioned to a target biopsy area of the ventricular septum; the surface of the extending end of the CSP delivery sheath is provided with a buffering assembly used for buffering the pressure generated when the CSP delivery sheath makes contact with the myocardial inner wall. Through the directional guiding effect of the CSP delivery sheath, the myocardial biopsy forceps and the inner wall of the myocardial form accurate vertical contact, the success rate of deep myocardial sampling is increased, and damage to the myocardial is reduced by reducing the number of times that an instrument penetrates through the tricuspid valve.

A surgical method for delivering a drug solution to myocardium includes the steps of: inserting a catheter into at least one of a coronary artery and a coronary vein, the catheter having a lumen, a lateral opening connecting the lumen and outside of the catheter, and a radiopaque marker indicating a position of the lateral opening; rotating the catheter while observing the marker such that an orientation of the lateral opening becomes a predetermined orientation with respect to a treatment target site; projecting a puncture needle through the lateral opening; piercing a myocardium of the treatment target site with the puncture needle; and injecting a drug solution containing therapeutic cells or chemical compounds from the puncture needle into the myocardium.

A non-invasive method for cardiac arrhythmia risk stratification may include identifying, based at least on an electrical recording of a patient, a cardiac depolarization simulation and a cardiac repolarization simulation corresponding to an electrical recording of a patient. One or more regions of increased spatial repolarization gradient in which a first area of a myocardium of the patient exhibits a first repolarization rate that differs from a second repolarization rate of a second area of the myocardium by an amount then divided by the spatial distance between the two regions, by a threshold value may be determined based on the cardiac depolarization simulation and the cardiac repolarization simulation. A risk of cardiac arrhythmia for the patient may be determined based a magnitude of the increased spatial repolarization gradient. Moreover, a treatment plan for the patient may be determined based on the magnitude and / or location of the increased spatial repolarization gradient.