31 results about "Myocar dial" patented technology

Devices, systems, and methods for causing retrograde oxygenated blood flow in at least a portion of the venous system of the myocardium are disclosed. Devices and methods include a method for causing retrograde oxygenated blood flow in at least a portion of the venous system of the myocardium, the method comprising: implanting a variable occluder in a coronary sinus region proximate a left atrium, wherein the variable occluder is configured to gradually increase a level of blood flow restriction over a period of days to enable a venous system of the myocardium to compensate for increased pressure caused by the gradual increase in the level of blood flow restriction; and following venous system compensation, shunting oxygenated blood flow into the coronary sinus to cause retrograde flow of oxygenated blood in at least a portion of the venous system of the myocardium to thereby enable revascularization of the myocardium.

Systems and methods are disclosed for to determining a blood supply and blood demand. One method includes receiving a patient-specific model of vessel geometry of at least a portion of a coronary artery, wherein the model is based on patient-specific image data of at least a portion of a patient's heart having myocardium; determining a coronary blood supply based on the patient-specific model; determining at least a portion of the myocardium corresponding to the coronary artery; determining a myocardial blood demand based on either a mass or a volume of the portion of the myocardium, or based on perfusion imaging of the portion of the myocardium; and determining a relationship between the coronary blood supply and the myocardial blood demand.

The invention provides a processing method and device based on a heart three-dimensional image, equipment and a medium. The processing method comprises the steps of obtaining three-dimensional image data of a heart; performing heart chamber segmentation according to the three-dimensional image data to obtain structure information of each area of the heart; determining the long axis of the left ventricle and the inner diameter and the outer diameter of the cardiac muscle according to the structural information; constructing a three-dimensional mapping of the myocardial wall thickness, and reflecting the form distribution of the myocardium in the space; segmenting the myocardium according to the three-dimensional mapping of the myocardial wall thickness and the long axis to generate segmented region data; and training and outputting a cardiomyopathy classification model through a pre-trained classification model in combination with the segmented region data. According to the method, feature vectors after dimension reduction are utilized to train a cardiomyopathy classification model. By generating a detection report containing an abnormal region position and classification confidence, the method improves the accuracy and efficiency of cardiomyopathy auxiliary detection by fusing image processing, feature extraction and machine learning technologies.

The invention provides a hypertrophy myocardial ablation device, which comprises a patch, and is characterized in that an electromagnetic coil is arranged in the patch and is used for generating an electromagnetic field; one end of the connecting piece is fixedly connected with the patch, and the other end of the connecting piece is provided with a hook-shaped structure; and the control assembly controls the intensity and the change frequency of the electromagnetic field generated by the electromagnetic coil. The device has the advantages that non-invasive controllable ablation of hypertrophy myocardium is achieved by integrating the electromagnetic coil, the connecting piece, the control assembly, the electrocardio collecting assembly and the intracardiac pressure collecting assembly, generation and change of an electromagnetic field are accurately controlled by collecting and analyzing heart data in real time, and high efficiency and safety of treatment are guaranteed.

The present invention belongs to the technical field of pulsed electric field ablation for hypertrophic cardiomyopathy, and specifically relates to a pulsed electric field ablation device for hypertrophic cardiomyopathy. The device comprises a pulse generator (1). A flexible catheter (2) is fixedly mounted on one side of the pulse generator (1), and a slidably connected sliding member (3) is arranged on the outer surface of the flexible catheter (2). By means of the arrangement of an auxiliary ablation assembly (6), a real-time three-dimensional echocardiography can be generated during the ablation process, and a relatively clear cardiac structure image can be provided for a doctor by means of the three-dimensional echocardiography, such that the doctor can better determine the region of hypertrophied myocardium. Moreover, data analysis is performed on the hearts of a large number of patients by means of artificial intelligence and a machine learning algorithm inside a high-speed analog-to-digital converter to generate a personalized cardiac model, so as to assist the doctor in accurate positioning, thereby reducing the number of times of adjusting the position of a PFAD electrode catheter, shortening the time required by the doctor during surgery, and reducing the difficulty of surgery treatment.

The invention discloses a processing method and device based on a heart three-dimensional image, equipment and a medium. The method comprises the following steps: acquiring a heart three-dimensional image and a chamber segmentation result to obtain a left ventricular heart cavity and a cardiac muscle; according to the inner diameter and the outer diameter of the myocardial, constructing a three-dimensional inner diameter curved surface and generating myocardial wall thickness mapping; determining a pre-trained classification model and constructing two-channel input of the classification model; inputting the curved surface and the mapping into a first channel of a model, and combining whole heart segmentation or original image data of a second channel; and processing dual-channel input through the model, and outputting a cardiomyopathy classification result. According to the method, a complete spatial form is reserved through the three-dimensional inner diameter curved surface and wall thickness mapping, and precise and robust classification of various cardiomyopathy such as hypertrophic cardiomyopathy and dilated cardiomyopathy is realized by combining dual-channel feature fusion and interactive calibration of a space guidance mask; the problems of efficiently and accurately extracting features from a complex three-dimensional heart image and automatically identifying diseases are solved.

The embodiment of the invention discloses a three-dimensional myocardial scar visualization system. According to one specific embodiment, the system comprises a data processing end configured to perform heart structure and scar segmentation on target heart magnetic resonance data to obtain a binary tag graph for the heart and the myocardium; constructing an individualized ventricular network and a scar three-dimensional surface model based on the binary label graph; generating an initial myocardial scar three-dimensional model; generating lead implantation track information; generating a myocardial scar three-dimensional model according to the lead implantation track information; and the model application end is configured to perform model rendering on a target application page according to the model parameters corresponding to the myocardial scar three-dimensional model sent by the data processing end so as to provide an interactive operation function and generate a clinical report. According to the embodiment, accurate and visual three-dimensional visual decision support can be provided for preoperative planning and intraoperative navigation of heart diseases, so that the accuracy of surgical planning and the clinical working efficiency are remarkably improved.

The present application relates to the field of food, health care products and medicine, and specifically relates to a purslane oral composition for regulating blood lipid and resisting atherosclerosis, and a preparation method and application thereof. The present application takes purslane extract, galangal extract and borneol as core components, and realizes the synergistic effects of lipid regulation, anti-inflammation, reduction of plaque area, stabilization of vulnerable plaque, mild anti-thrombus and myocardial protection through scientific proportioning. The bioavailability is significantly improved by combining the tongue sublingual absorption of borneol and the mucosal penetration of galangal volatile oil. The composition has comprehensive targets, definite effects and good safety, and can be made into oral dosage forms such as buccal tablets, dripping pills and oral disintegrating tablets, and is suitable for daily oral care of cardiovascular sub-healthy people.

The invention discloses a cardiac magnetic resonance T1mapping image synthesis method, which comprises the following steps of: acquiring a plurality of groups of samples, each group comprising native T1mapping images and movie imaging sequence images, determining a heart region corresponding to each native T1mapping image, identifying initial associated image pairs of end diastole and end systole from the same group of movie images according to the heart region corresponding to each native T1mapping image, and synthesizing the initial associated image pairs of the end diastole and end systole according to the initial associated image pairs of the end diastole and end systole. Obtaining a target associated image pair corresponding to the heart preset region after segmentation, and training the constructed initial diffusion model to obtain a target model; respectively extracting myocardial tissue texture features and heart morphological dynamic features in a specific period from each film imaging sequence image; and inputting the tissue texture features and the heart morphological dynamic features into a target model, and performing inverse diffusion denoising on random noise randomly sampled from Gaussian distribution to obtain a synthesized T1mapping image. According to the method, rapid, efficient and high-quality T1mapping image synthesis can be realized.

The present invention relates to a myocardial spectrometer probe comprising at least two separate light guides (120A, 120B) insertable into tissue, wherein a first light guide (120A, 120B) is arranged to deliver light and a second light guide (120A, 120B) is arranged to collect light, and wherein the first light guide (120A, 120B) and the second light guide (120A, 120B) are arranged separately from each other.

This invention discloses an automatic identification and classification method for scarred myocardium based on cine magnetic resonance imaging (CMRI) and deep learning. After preprocessing cardiac cMRI images, the method extracts the relative motion and imaging features of the left ventricular myocardium. A multimodal feature fusion network is then used for training and prediction to identify and classify five different types of scarred myocardium. The extraction of relative motion and imaging features enables an accurate and detailed description of the state of scarred myocardium. The multimodal feature fusion network model captures the compensatory effects of long-distance scarred myocardium movement, the non-rigid deformation motion patterns of the myocardium, and the spatiotemporal relationship between myocardial motion and morphology. This invention achieves high efficiency and accuracy in identifying and classifying scarred myocardium, saving doctors time and effort in diagnosing cardiovascular diseases leading to scarred myocardium, reducing patient suffering, and facilitating a more stable and simpler examination and diagnostic method.

Ischemic heart disease is a leading cause of death and reduced quality of life worldwide. Although revascularization strategies significantly reduce mortality after acute myocardial infarction (MI), many patients with MI develop chronic heart failure over time. We previously reported that human recombinant ANGPTL4 counteracts ischemia-induced vascular endothelial growth factor signaling and disruption of endothelial cell-cell adhesion, thereby inhibiting vascular permeability. We were able to demonstrate that ANGPTL4 administration before MI resulted in protection of the coronary capillary network, no-reflow syndrome, and reduced infarct size in mice. We also demonstrated that the therapeutic effects observed with ANGPTL4 under ischemic conditions were caused by the FLD fragment, not the CCD fragment (WO 2016 / 110498). To further examine the therapeutic potential of the FLD fragment of ANGPTL4 at the onset of reperfusion, we herein used a porcine model, a clinically relevant model of acute myocardial infarction that can be easily and safely translated into patient treatment. We demonstrated that local (antegrade) delivery of the FLD ANGPTL4 to infarcted porcine hearts can efficiently target the lesion site in a clinically relevant manner. A single administration of the FLD of ANGPTL4 improved cardiac function, infarct size, fibrosis, and adverse remodeling parameters 28 days after MI. Short-term MI experiments, coupled with complementary mouse studies, demonstrated myocardial protection. Thus, a single administration of the FLD of ANGPTL4 can reduce ischemia-reperfusion injury and protect against adverse postischemic cardiac remodeling and subsequent ischemic heart failure.

The invention relates to a myocardial progenitor cell and drug double-loaded hydrogel biological material and application thereof, and particularly provides a biological material compound which comprises an organic compound, living cells and a loading material, and the organic compound can induce expression of protease. The compound is used in the treatment process of myocardial infarction (MI), the functionality of transplanted cells is improved, and effective repair and functional recovery of damaged myocardium are promoted.

A cardiac angiography analysis method, an angiography data processing method and an ultrasonic imaging device, the method comprising: when the heart of a target object is in a resting state, injecting a contrast agent to the heart of the target object, emitting a first ultrasonic wave to the heart containing contrast agent microbubbles, and generating a first angiography image; acquiring a first myocardial angiography parameter of the myocardial region of interest as a resting parameter based on the first angiography image; when the heart of the target object is in the load state, a contrast agent is injected into the heart of the target object, second ultrasonic waves are emitted to the heart containing contrast agent microbubbles, and a second contrast image is generated; acquiring a second myocardial angiography parameter of the myocardial region-of-interest as a load parameter based on the second angiography image; and determining reserve parameters of the myocardial region of interest based on the resting parameters and the load parameters, and outputting the reserve parameters or information reflecting the reserve parameters. According to the method, the reserve function and dynamic change of the myocardium can be accurately evaluated.

The application provides use of tenascin C in preparation of a drug for promoting controllable regeneration of myocardium or myocardial repair. The application also provides a heart patch containing tenascin C. The application further provides a preparation method of the heart patch. The application also provides use of the heart patch in preparation of a drug for preventing controllable regeneration or myocardial repair. The method of the application can improve the safety of myocardial regeneration and avoid the burden on the body caused by excessive enlargement of the heart.

The invention relates to the technical field of myocardial biopsy, in particular to a myocardial biopsy sampling device, system and method based on a CSP delivery sheath, and the device comprises a pair of myocardial biopsy forceps and the CSP delivery sheath which is used for guiding the myocardial biopsy forceps to move to the inner wall of the myocardial and is in vertical contact with the inner wall of the myocardial; placing the CSP delivery sheath into the body of the patient by taking the axillary vein as a placing path until the extending end of the CSP delivery sheath is vertically positioned to a target biopsy area of the ventricular septum; the surface of the extending end of the CSP delivery sheath is provided with a buffering assembly used for buffering the pressure generated when the CSP delivery sheath makes contact with the myocardial inner wall. Through the directional guiding effect of the CSP delivery sheath, the myocardial biopsy forceps and the inner wall of the myocardial form accurate vertical contact, the success rate of deep myocardial sampling is increased, and damage to the myocardial is reduced by reducing the number of times that an instrument penetrates through the tricuspid valve.

A surgical method for delivering a drug solution to myocardium includes the steps of: inserting a catheter into at least one of a coronary artery and a coronary vein, the catheter having a lumen, a lateral opening connecting the lumen and outside of the catheter, and a radiopaque marker indicating a position of the lateral opening; rotating the catheter while observing the marker such that an orientation of the lateral opening becomes a predetermined orientation with respect to a treatment target site; projecting a puncture needle through the lateral opening; piercing a myocardium of the treatment target site with the puncture needle; and injecting a drug solution containing therapeutic cells or chemical compounds from the puncture needle into the myocardium.

A non-invasive method for cardiac arrhythmia risk stratification may include identifying, based at least on an electrical recording of a patient, a cardiac depolarization simulation and a cardiac repolarization simulation corresponding to an electrical recording of a patient. One or more regions of increased spatial repolarization gradient in which a first area of a myocardium of the patient exhibits a first repolarization rate that differs from a second repolarization rate of a second area of the myocardium by an amount then divided by the spatial distance between the two regions, by a threshold value may be determined based on the cardiac depolarization simulation and the cardiac repolarization simulation. A risk of cardiac arrhythmia for the patient may be determined based a magnitude of the increased spatial repolarization gradient. Moreover, a treatment plan for the patient may be determined based on the magnitude and / or location of the increased spatial repolarization gradient.

A method for manufacturing a multilayer engineered heart muscle that includes (i) providing a liquid reconstitution mixture in a mould and (ii) culturing the mixture. The method includes a sequential addition of one or more further liquid reconstitution mixtures to obtain a multilayer engineered heart muscle. The muscle ideally has the form of a patch, a pouch, or a cylinder. Furthermore, a multilayer engineered heart muscle having collagen, cardiac myocytes and non-myocytes originating from at least 2 layers is disclosed. The multilayer engineered heart muscle forms the basis for several in vitro and in vivo applications such as the production of a multilayer engineered heart muscle for use in a patient, for example for use in heart repair.

The invention belongs to the technical field of pericardiocentesis, and discloses a pericardiocentesis device which comprises a drainage main pipe, a supporting inner core, a puncture needle and a puncture guide wire, the supporting inner core is arranged in the drainage main pipe in a penetrating mode, the outer diameter of the supporting inner core is matched with the inner diameter of the drainage main pipe, the puncture needle is arranged in the supporting inner core in a penetrating mode, and a hollow cavity channel is formed in the puncture needle. A puncture guide wire is arranged in the hollow cavity channel in a penetrating mode, the puncture guide wire is in a J shape in an unstressed state, the puncture guide wire comprises a pointed end section, a bent section, a supporting section and a hard section, and developing marks are arranged at the pointed end section, the puncture end of the puncture needle and the puncture end of the drainage main pipe. The drainage main pipe is supported through the supporting inner core, and the strength of the drainage main pipe is improved; the skin and subcutaneous tissue of a patient can be easily punctured through the puncture needle, the outer layer of the pericardial cavity is punctured through the puncture guide wire and enters the pericardial cavity, the bent section forms a J shape in the pericardial cavity, the contact probability of the needle tip and the non-punctured part and the myocardial is reduced, and the safety of puncture operation is improved.

The invention provides a bionic myocardial electronic patch for personalized adaptation of mechanical properties of myocardial soft tissue and a preparation method thereof, and relates to the field of regenerative medicine. The invention provides a bionic myocardial electronic patch adapted to mechanical properties of myocardial soft tissue in a personalized manner. The bionic myocardial electronic patch comprises a telescopic flexible fiber electrode, a tissue engineering fiber scaffold deposited on the surface of the telescopic flexible fiber electrode, a gold-plated nano layer on the surface of the fiber electrode and a PDMS passivation layer. After the bionic myocardial electronic patch provided by the invention is compounded and inoculated with hydrogel of myocardial cells differentiated from human pluripotent stem cells, nondestructive monitoring and transmission of electrical stimulation are realized, and meanwhile, the mechanical property of the myocardial tissue can be adjusted and adapted by the mechanical property of the tissue engineering fiber scaffold. The bionic myocardial electronic patch provided by the invention integrates the flexible electrode and the fiber scaffold, and can meet the biomechanical properties of monitoring, stimulating and adapting to myocardium at the same time.

Devices, systems, and methods for revascularization of the myocardium are disclosed, such as an intravascular medical device for shunting and selectively regulating anatomical fluid flow. A tubular shunt is configured for deployment in a passageway between a first organ and a second adjacent organ and to bridge a first cavity in the first organ and a second cavity in the second organ. A stabilizer is configured to stabilize the tubular shunt in the passageway. A flow deflector extends from the tubular shunt and has a surface for deflecting flow in the second cavity.

The embodiment of the invention provides a data processing method and device, and belongs to the technical field of tomography. The method comprises the following steps: acquiring a CT image of a chest and SPECT image domain body data; segmenting the CT image to obtain a myocardial mask; the myocardial mask comprises three-dimensional anatomical contour information of the myocardial; registering the CT image domain body data and the SPECT image domain body data to obtain target SPECT image domain body data; determining a myocardial region and a blood pool region according to the myocardial mask and the target SPECT image domain body data; and the myocardial blood flow corresponding to the myocardial area and the blood pool area is determined, so that the determination precision of the myocardial blood flow is improved.

A pulsatile flow device configured to be implanted in a ventricle of a heart, has: an enclosure having an internal volume, the enclosure having a wall side for facing a myocardium of the heart and a ventricle side for being exposed to blood flowing in the ventricle, the ventricle side defined at least partially by a membrane, the membrane movable between a diastolic position and a systolic position, the internal volume greater in the systolic position than in the diastolic position; a frame located within the enclosure, the frame engaging the wall side of the enclosure, the frame exerting a force on the wall side to resist deformation of the wall side of the enclosure; and an actuator operatively connected to the enclosure, the actuator operable to move the membrane between the diastolic position and the systolic position.

The present invention relates to compositions, methods, and devices for preventing irregular electromechanical waves in the myocardium that lead to pathological conditions as arrhythmia. In particular, the invention relates to compositions and methods to increase the conductivity of the myocardium to restore an impairment of the electrical conduction system of the heart. To that end substances with high conductivity, as carbon nanotube suspensions or metal nanowire suspensions, are injected in the myocardium at closely adjacent locations on circular or open lines or are introduced in patches of cardiomyocytes that are subsequently placed on the myocardium.

A bendable cutting apparatus for myocardium and a system with the same are provided. The cutting apparatus includes a cutting portion, a bendable portion, and a driving portion. The bendable portion is connected between the cutting portion and the bendable portion, the cutting portion is driven by the driving portion to cut down a target, and the bendable portion is configured to bend in response to being tensioned and loosen by the driving portion.

The invention discloses an intelligent hemodynamics simulation platform based on deep learning, and relates to the technical field of medical instruments. The platform comprises a blood flow simulation device, a control system and a secondary bypass device, the blood flow simulation device is used for simulating a left descending branch artery and comprises a blood vessel pipeline, and a constant-temperature water tank for simulating blood supply in a human body temperature environment, a first motor for simulating a bridge blood vessel extrusion scene and a first pressure regulating valve for simulating myocardial bridge far-end vascular resistance which are sequentially arranged on the blood vessel pipeline; the secondary bypass device is used for simulating a coronary artery bypass transplantation CABG branch so as to bypass a myocardial bridge extrusion part and recover blood supply of ischemic myocardium; and the second-stage bypass device comprises a first water pump, a first compliance chamber and a second pressure regulating valve which are connected in sequence. The control system is integrated with a deep learning model, and driving signals of all parts of the simulation platform are generated through the deep learning model. According to the simulation platform, accurate simulation of treatment intervention of coronary artery bypass grafting (CABG) is realized.

This invention provides a myocardial patch and its preparation method, addressing the obstacles to the use of naringin in myocardial patches, mainly including dissolution, storage, and bioavailability issues. The myocardial patch contains naringin, which acts as an active substance for anti-inflammatory and cardiac repair. This invention processes naringin into a myocardial patch, overcoming numerous obstacles to its use in myocardial patches, while leveraging the advantages of unsaturated fatty acids and naringin for myocardial health. Its application in advanced heart failure treatment products can improve the therapeutic effect of heart failure.

The application provides an ultrasonic device and a myocardial data processing method. The echo signals obtained in the process of tissue Doppler detection of the heart are combined with the contraction and diastole of the myocardium, a plurality of groups of line data are extracted from the digital signals of the echo signals, and the time length of each group of line data is one cardiac cycle. The data of each time point extracted from the plurality of groups of line data are subjected to data mixing processing to obtain myocardial data of a target myocardium. Each group of line data extracted is real detection data, and the data after the data mixing processing can better reflect the actual situation of myocardial movement, that is, the restoration degree of myocardial movement is improved.

The application relates to a lead for pacing, comprising an insulation layer, an electrode head assembly and an anchoring member, the electrode head assembly comprising an operating part and an electrode head, the electrode head being arranged at the distal end of the operating part, the electrode head assembly being movable relative to the insulation layer between a first position and a second position, the electrode head assembly in the first position being located in the insulation layer, the electrode head assembly in the second position, the electrode head extending out of the insulation layer, the electrode head being a non-smooth surface, and the area of the minimum cross section of the electrode head being 4.0mm 2 The lead for pacing of the application is arranged with a non-smooth surface of the electrode head, so that the electrode head can be slowly inserted into the interventricular septal myocardial tissue and easily screwed in even without a tapered structure. The arrangement can ensure that the cross section is not similar to a tapered structure with a small cross section area, so that the electrode head is not easy to break when inserted into the cardiac tissue, and the removal of the lead causes less damage to the normal myocardium due to the small cross section area.