Magnetic resonance imaging

An image signal intensity, contrast agent technology, applied in the MRI field, which can solve the problem of not providing vitality or function, costing patients and healthcare time

Active Publication Date: 2010-03-24
佩·于奇 +3
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this approach requires a wait time of 3 to 6 hours after administration of the contrast agent and initiation of imaging, thus being costly to the patient and healthcare time
Furthermore, no means are provided for assessing different levels of viability or function

Method used

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  • Magnetic resonance imaging
  • Magnetic resonance imaging
  • Magnetic resonance imaging

Examples

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Embodiment Construction

[0124] Magnetic resonance imaging:

[0125] MR examinations were performed on 10 patients 3-12 weeks after an acute coronary attack accompanied by an acute myocardial infarction (AMI) attack. All patients underwent percutaneous coronary intervention (PCI) for revascularization immediately after administration due to AMI.

[0126] Examinations were performed on a Siemens Magnetom Symphony 1.5 Tesla scanner (software version: Syngo 2002B, VA21B. Gradient field strength: 30 mT / m) with Quantum gradients. Recordings were performed by in-body phased array surface coils. Electrocardiogram (ECG) signals are used for heart rate monitoring and sequence triggering.

[0127]Steady-state free precession (true fast imaging of steady-state precession (true-FISP)) photographic short-axis slices were made covering the length of the ventricle. Each slice was obtained during a breath-holding procedure in which the slice thickness was 8 mm and the slice interval was 10 mm. One slice was selec...

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Abstract

A method of determining the amount of intracellular manganese in the myocardium of an individual pre-administered with a manganese contrast agent, or a pharmaceutically acceptable salt thereof, comprising subjecting said individual to a MRI procedure to assess the signal intensity (SI) of images, or more preferably the longitudinal relaxation rate, R1.

Description

technical field [0001] The present invention relates to Magnetic Resonance Imaging (MRI), and in particular to methods and applications of MRI in which manganese contrast agents are employed to determine tissue viability / function and thereby detect cardiac remodeling at graded levels. Background technique [0002] Ischemic heart disease (IHD) due to arteriosclerosis, thrombus and / or arterial occlusion remains the leading cause of death in Western countries. The most common potentially fatal morbidities associated with IHD are acute myocardial infarction (AMI), cardiac arrhythmias, and heart failure during or after AMI. [0003] In recent years, AMI treatment has improved significantly, and many people are now spared AMI due to the ability to revascularize with medical and / or percutaneous interventions. Unfortunately, however, a substantial number of people receiving this treatment, and those with even fewer infarcts, later develop left ventricular remodeling, and heart fail...

Claims

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Application Information

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IPC IPC(8): A61K49/10
CPCA61K49/103A61P9/00A61K49/10A61B5/055
Inventor 佩·于奇阿尔内·舍尔德亨里克·W·拉松海迪·布鲁罗克
Owner 佩·于奇
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