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Willow branch modification method and application thereof as bone repair material

A technology of modification of willow branches, applied in medical science, tissue regeneration, prosthesis, etc., can solve the problems of insufficient bone formation ability of willow branches, and achieve large-scale industrial processing, strong controllability, and mild reaction conditions Effect

Inactive Publication Date: 2020-12-29
SOUTHWEAT UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Aiming at the insufficient bone formation ability of willow branch, the object of the present invention is to provide a modification method of willow branch and its application as a bone repair material, through the modification method of the present invention, in order to promote the osteogenesis ability of willow branch, And can be stably used as bone repair material

Method used

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  • Willow branch modification method and application thereof as bone repair material
  • Willow branch modification method and application thereof as bone repair material
  • Willow branch modification method and application thereof as bone repair material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] A method for modifying willow branches, the processing steps are as follows:

[0037] Remove the skin of willow branches, wash them three times with ultrapure water and absolute ethanol, and then freeze-dry them; soak the dried willow branches in a mixed solution of 100mL DMF (N,N-dimethylformamide) and 20g urea After 0.5 hours, 50 mL of phosphoric acid was added dropwise to the mixed solution at a rate of 1 mL / min; the mixture was mechanically stirred in a water bath at 40 ° C for 1 h, and after the reaction, the mixture was cooled to room temperature; finally, the wicker was cooled from the cooled The mixture was taken out, washed with distilled water until neutral, and then freeze-dried.

[0038] Verification study on the bone-inducing ability (HA mineralization) of willow branches by alternate immersion method. Prepare 0.2mol / L CaCl before mineralization 2 and Na 3 PO 4 solution. The freeze-dried modified willow branches were firstly treated with CaCl 2 Soak i...

Embodiment 2

[0040] A method for modifying willow branches, the processing steps are as follows:

[0041] The willow branches were removed from the skin, washed four times with ultrapure water and absolute ethanol, and then freeze-dried; the dried willows were soaked in a mixed solution of 200mL DMF and 30g urea for 1 hour, and then 60mL phosphoric acid was added at 2mL / The speed of min was added to the mixed solution dropwise; the mixture was mechanically stirred in a water bath at 50°C for 2 hours, and after the reaction, the mixture was cooled to room temperature; finally, the wicker was taken out from the cooled mixture, washed with distilled water until neutral, Then freeze dry.

[0042] The verification experiment and characterization method of modified willow branch's ability to induce osteogenesis are the same as in Example 1. The results showed that white HA was formed on the outer surface and inner pores of the modified willow branches. The HA particles are mainly lumpy, but t...

Embodiment 3

[0044] A method for modifying willow branches, the processing steps are as follows:

[0045] The skin of the willow branches was removed, washed five times with ultrapure water and absolute ethanol, and then freeze-dried. Soak the dried wicker in a mixed solution of 300mL DMF and 40g urea for 2 hours. Then, 70 mL of phosphoric acid was added dropwise to the mixed solution at a rate of 3 mL / min. The mixture was mechanically stirred in a water bath at 60 °C for 3 h. After the reaction, the mixture was cooled to room temperature. Finally, the wicker is removed from the cooled mixture, washed with distilled water until neutral, and freeze-dried.

[0046] The verification experiment and characterization method of modified willow branch's ability to induce osteogenesis are the same as in Example 1. The results showed that more white HA was formed on the outer surface and inner pores of the modified willow branches. The HA particles showed a mixture of massive and fibrous morpho...

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Abstract

The invention provides a willow branch modification method and application thereof as a bone repair material, and belongs to the technical field of natural material modification treatment. The willowbranch modification method comprises the following steps: (1) willow branches are cleaned and dried; (2) the dried willow branches are soaked in a mixed solution of urea and DMF for 0.5-3 h, the mass-volume ratio of the urea to the DMF is (2-6) g: (10-50) mL, then phosphoric acid is dropwise added into the mixed solution, and the volume ratio of the phosphoric acid to the DMF is (1-2): (2-10); (3)the mixture treated in the step (2) is put into a constant-temperature water bath and stirred for reaction for 1-5 hours, and the mixture is cooled to room temperature after the reaction is finished;and (4) wickers are taken out of the cooled mixture and washed with distilled water to be neutral, and then subjected to freeze-drying for later use. By means of the modification method, the bone forming capacity of the willow branches can be promoted, the modified willow branches are used for replacing common willow branches in a traditional Chinese medicine willow branch bone setting technology, and bone growth can be induced and promoted.

Description

technical field [0001] The invention belongs to the technical field of natural material modification and medical application thereof, and specifically relates to a willow branch modification technology, in particular to a willow branch modification method and its application as a bone repair material. Background technique [0002] Wicker bone grafting is an ancient and mysterious technique in the treatment of open fractures in traditional Chinese medicine. It has been spread in Jiangsu, Guangxi, Sichuan, Hunan and other provinces. In the late Ming and early Qing Dynasties (the middle of the 17th century), Fu Qingzhu, a famous thinker, calligrapher, and medical scientist, recorded in "Golden Needle Dushi": the peeled wicker was shaped into a bone, and the middle was opened to form a bone cavity, and then it was placed in two sections The middle of the cut surface of the broken bone is used to replace the resected bone. Sprinkle a kind of "shiqingsan" that can grow muscles on...

Claims

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Application Information

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IPC IPC(8): A61L27/36A61L27/50
CPCA61L27/3637A61L27/365A61L27/3687A61L27/3691A61L27/50A61L2300/412A61L2430/02
Inventor 刘勋吴超群伍波李兆乾裴重华
Owner SOUTHWEAT UNIV OF SCI & TECH
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