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Wearable intraocular pressure monitoring sensor and preparation method thereof

A monitoring sensor and sensor technology, applied in the field of medical devices, can solve problems such as differences, inability to obtain intraocular pressure data, and inability to measure intraocular pressure in glaucoma patients, and achieve the effect of improving sensitivity and high transmittance

Pending Publication Date: 2021-01-05
GRIMAT ENG INST CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Therefore, the measured intraocular pressure is affected by physiological indicators such as corneal thickness, curvature, and elasticity, and there is a certain difference from the real intraocular pressure.
[0005] All the above methods need to be completed with the assistance of a doctor. Glaucoma patients cannot measure intraocular pressure by themselves in daily life, and cannot obtain intraocular pressure data in daily life between two visits to the doctor.

Method used

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  • Wearable intraocular pressure monitoring sensor and preparation method thereof
  • Wearable intraocular pressure monitoring sensor and preparation method thereof
  • Wearable intraocular pressure monitoring sensor and preparation method thereof

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preparation example Construction

[0035] A preparation method of an intraocular pressure monitoring sensor, comprising:

[0036] (1) using polydimethylsiloxane (PDMS) as the base layer;

[0037] (2) Mix the reduced graphene oxide solution and the carbon nanotube solution in a volume ratio of 1:1-5:1, put it into the ultrasonic atomization spraying equipment, and spray it onto the mask plate with the designed Wheatstone bridge circuit. A film is formed on the base layer, and the film obtained by spraying is thermally reduced, which is the strain sensing layer; the concentration of the reduced graphene oxide solution is 0.5mg-2mg / mL, and the concentration of the carbon nanotube solution is 0.2-0.5mg / mL; The total spraying time is 3-6 hours; the process conditions of thermal reduction: under the condition of 180 ℃-200 ℃, the reduction is 2-3 hours;

[0038] (3) Coating Parylene on the strain sensing layer to form an encapsulation layer, and then forming a certain curvature radius of 8-10 mm by thermoplastic to o...

Embodiment 1

[0043] (1) using polydimethylsiloxane (PDMS) as the base layer;

[0044] (2) Mix the reduced graphene oxide solution and the carbon nanotube solution in a volume ratio of 1:1, put it into an ultrasonic atomization spraying equipment, and spray it onto the base layer through a mask with a designed Wheatstone bridge circuit to form Thin film, thermal reduction of the film obtained by spraying is the strain sensing layer; wherein, the concentration of the reduced graphene oxide solution is 0.5 mg / mL, and the concentration of the carbon nanotube solution is 0.2 mg / mL; the total spraying time is 3 hours ; Process conditions for thermal reduction: at 180°C, reduction for 2 hours; the thickness of the formed strain-sensing layer is 100 μm;

[0045](3) Coat the top of the strain-sensing layer with Parylene to form an encapsulation layer, and then use three metal spherical molds (12mm, 10mm and 8mm) with gradually decreasing curvature radii for shaping. First, put the obtained sensor ...

Embodiment 2

[0047] (1) using polydimethylsiloxane (PDMS) as the base layer;

[0048] (2) Mix the reduced graphene oxide solution and the carbon nanotube solution in a volume ratio of 5:1, put it into the ultrasonic atomization spraying equipment, and spray it onto the base layer through the mask that has designed the Wheatstone bridge circuit to form Film, the film obtained by spraying is thermally reduced, which is the strain sensing layer; wherein, the concentration of the reduced graphene oxide solution is 2 mg / mL, and the concentration of the carbon nanotube solution is 0.5 mg / mL; the total spraying time is 6 hours; Process conditions for thermal reduction: reduction at 200°C for 3 hours; the thickness of the formed strain-sensing layer is 200 μm;

[0049] (3) Coat the top of the strain-sensing layer with Parylene to form an encapsulation layer, and then use three metal spherical molds (14mm, 12mm and 10mm) with gradually decreasing radii for shaping. First, put the obtained sensor s...

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Abstract

The invention discloses a wearable intraocular pressure monitoring sensor. The wearable intraocular pressure monitoring sensor comprises a substrate layer, a strain sensing layer and a packaging layerwhich are sequentially arranged from bottom to top, and the substrate layer and the packaging layer can be attached to the eyeball shape of a user in a matched mode. The strain sensing layer is usedfor sensing the eyeball curvature change of the user and converting the eyeball curvature change into an electric signal, and the strain sensing layer is composed of reduced graphene oxide and a carbon nanotube material. The strain sensing material is adopted in the wearable intraocular pressure monitoring sensor, so that the sensitivity of the wearable intraocular pressure monitoring sensor is improved. Meanwhile, the reduced graphene oxide and a carbon nanotube film have relatively high transmittance, so that the eyesight of the user is not influenced when intraocular pressure monitoring iscarried out on the user.

Description

technical field [0001] The invention relates to the technical field of medical devices, in particular to a wearable intraocular pressure monitoring sensor and a preparation method thereof. Background technique [0002] Glaucoma is the leading irreversible blinding eye disease. There are currently about 60 million glaucoma patients worldwide, of which 8.4 million are blind. In China, the prevalence of glaucoma in people over the age of 40 is about 2.6%, of which the blindness rate is about 30%. The pathogenesis of glaucoma is complex, and it is generally believed to be related to the increase of intraocular pressure (sometimes also called "intraocular pressure"). [0003] Because most glaucoma patients do not have any symptoms in the early stage, patients often go to see a doctor because of visual field defect, but the visual function damage at this time is very serious. In developed countries, half of glaucoma patients do not know they have glaucoma; in developing countri...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B3/16
CPCA61B3/16
Inventor 樊彦艳屠海令赵鸿斌魏峰
Owner GRIMAT ENG INST CO LTD
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