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Application of 6BIO in aspect of heart aging resistance

A kind of heart aging technology, applied in the application field of 6BIO in anti-cardiac aging

Pending Publication Date: 2021-01-05
SHANGHAI SIXTH PEOPLES HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, so far there is no rigorous scientific research to prove the anti-aging effect of 6BIO

Method used

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  • Application of 6BIO in aspect of heart aging resistance
  • Application of 6BIO in aspect of heart aging resistance
  • Application of 6BIO in aspect of heart aging resistance

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0032] Application of 6BIO in anti-aging of the heart

[0033] Materials and methods

[0034] 1. Animals and Handling

[0035] We obtained male young (2 months) and aged (18 months) C57BL / 6J mice from the Experimental Animal Center of the Fourth Military Medical University of the Chinese People's Liberation Army. All mice were housed in a specific pathogen-free (SPF) environment with light and temperature control, and had free access to food and water. Our experimental mice were divided into the following four groups, with eight mice in each group:

[0036] (1) Young male rats were intraperitoneally injected with 0.9% sodium chloride (10 ml / kg) every day;

[0037] (2) Aged male mice were intraperitoneally injected with 0.9% sodium chloride (10 ml / kg) every day;

[0038] (3) Treat aging male mice with rapamycin, inject rapamycin (4mg / kg) 10ml / kg saline intraperitoneally every day;

[0039] (4) Treat aged male mice with 6BIO, and inject 6BIO (10mg / kg) 10ml / kg saline intrape...

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PUM

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Abstract

The invention discloses an application of 6BIO in the aspect of heart aging resistance, and an application of the 6BIO in a medicine for treating or preventing heart aging. The medicine for treating or preventing the heart aging contains a therapeutically effective amount of the 6BIO and a pharmaceutically acceptable carrier. The 6BIO can delay or even reverse the heart aging by inhibiting mTOR and activating autophagy, research results provide a new thought for searching for effective drugs capable of preventing heart degenerative changes, and the 6BIO has very important practical significance and clinical value for prevention and treatment of heart diseases.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to the application of 6BIO in anti-aging of the heart. Background technique [0002] With age, the incidence of heart-related diseases increases significantly, and these heart aging-related changes include arrhythmia, cardiac fibrosis, decreased ventricular compliance, and degenerative changes of cardiomyocytes. Cardiac aging is an important issue affecting human health. In recent years, there have been more and more researches on aging, and the process of artificially controlling aging is just around the corner. The research on anti-aging drugs for the heart has gradually attracted the attention of a large number of researchers in the field of biomedicine. [0003] Finding effective drugs to delay heart aging and exploring its anti-aging effect and mechanism will help humans find ways to prevent the occurrence and development of degenerative heart diseases, explore measures to...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/404A61P39/06A61P9/00
CPCA61K31/404A61P39/06A61P9/00
Inventor 苗雅郭东豪钟远程丽珍沈赟李蔚李沁洁
Owner SHANGHAI SIXTH PEOPLES HOSPITAL