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Medical adhesive capable of being used for dense connective tissues

A connective tissue, adhesive technology, applied in surgical adhesives, applications, medical science, etc., can solve problems such as lack of scientific evidence

Pending Publication Date: 2021-01-05
STOMATOLOGICAL HOSPITAL OF CHONGQING MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Regarding the use of giant salamander mucus to prepare adhesives, Chinese Invention Patent Application Announcement No. CN104815349B discloses a method for preparing adhesives from giant salamander mucus, which only preliminarily explains the adhesive properties of giant salamander mucus used to make adhesives after being sterilized by gamma rays. The giant salamander mucus freeze-dried powder produced by this method has any material description and testing
In addition, Chinese Invention Patent Publication No. CN106581736A only briefly describes a method for manufacturing giant salamander mucus freeze-dried powder, and lacks scientific evidence to support the effect of this method
The use of giant salamander mucus to prepare adhesives for dense connective tissue has not been reported so far

Method used

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  • Medical adhesive capable of being used for dense connective tissues
  • Medical adhesive capable of being used for dense connective tissues
  • Medical adhesive capable of being used for dense connective tissues

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0027] The present invention provides medical adhesives useful for dense connective tissue and corresponding methods of preparing such medical adhesives. The preparation method of the medical adhesive that can be used for dense connective tissue provided by the present invention comprises the following steps: step a, collecting mucus from the skin of living giant salamander, and freeze-drying the mucus; step b, pulverizing and sieving the freeze-dried mucus to obtain Freeze-dried powder of giant salamander mucus in the required particle size range; step c, sterilizing the freeze-dried powder of giant salamander mucus to obtain a medical adhesive that can be used for dense connective tissue.

[0028] In order to achieve good overall effects such as adhesion and shear resistance, the particle size of the freeze-dried giant salamander mucus powder is selected to be less than 1000 μm, preferably between 10-300 μm.

[0029] The medical adhesive that can be used for dense connective...

Embodiment 1

[0032] Embodiment 1, can be used for the preparation of the medical adhesive of dense connective tissue repair

[0033] Step a, collecting mucus from the skin of living giant salamanders. The method of obtaining the mucus in step a should be carried out strictly in accordance with China's animal protection law, and it is not necessary to kill the giant salamander and should not cause permanent disability to the giant salamander. Mechanical stimulation or electrical stimulation can be used to obtain giant salamander mucus, and the giant salamander mucus is collected for future use.

[0034] In the step b, the collected giant salamander mucus is made into freeze-dried powder. It should be freeze-dried as soon as possible after collection, and the time from the completion of collection to the start of freeze-drying should not exceed 1 hour. The freeze-drying speed is set to drop 10-15°C per hour, and the temperature drops to -20°C within 4 hours. Then pulverize to obtain a fin...

Embodiment 2

[0039] Embodiment 2: the gelling effect of different aqueous solutions

[0040] In this example, a polydimethylsiloxane (PDMS) mold with a length of 10 mm and a depth of 5 mm was used to test the gel-forming properties of the medical adhesive for repairing dense connective tissue provided by the present invention with different aqueous solutions. At room temperature, one part of the giant salamander mucus freeze-dried powder (SSAD) obtained in Example 1 of the present invention was respectively mixed with different types and different parts by weight of aqueous solutions. The types and parts of the aqueous solution are shown in Table 1 below.

[0041] Table 1: The weight ratio of giant salamander mucus freeze-dried powder and aqueous solution in this embodiment

[0042]

[0043] After mixing SSAD with aqueous solutions of different systems, it was found that in each aqueous solution system mentioned in Table 1, when the mass parts of SSAD and the above-mentioned aqueous so...

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Abstract

The invention discloses a medical adhesive capable of being used for dense connective tissues. The medical adhesive contains an unmodified Andrias davidianus mucus freeze-dried powder component. Aftersterilization treatment, the medical adhesive not only retains relatively strong adhesion performance, but also kills bacteria to the greatest extent, and is particularly suitable for the adhesion ofthe dense connective tissues.

Description

technical field [0001] The invention belongs to the field of biological materials, and relates to an adhesive prepared by using natural components as raw materials, in particular to a medical adhesive that can be used for dense connective tissue. Background technique [0002] Tendons and ligaments are dense, tough bands of fibrous connective tissue that normally connect muscles to bones. Examples of tendons include the Achilles tendon, which connects the calf muscles to the heel bone, and the patellar tendon, which connects the kneecap to the tibia. Examples of ligaments include extracapsular ligaments located around the joint cavity, and intracapsular ligaments located within the joint cavity. [0003] Injuries to tendons and ligaments are common orthopedic problems. Tendons or ligaments can be damaged in many ways, including overuse, sprains, disease and general aging, among others. With the extension of human life span and more and more middle-aged people participating...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/00
CPCA61L24/0005A61L24/001A61L24/0042
Inventor 张曦木季平党如意
Owner STOMATOLOGICAL HOSPITAL OF CHONGQING MEDICAL UNIV
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