Pathogen analysis method and device based on high-throughput sequencing and computer equipment

An analysis method and pathogen technology, applied in the field of data processing, can solve the problems of low comparison efficiency and long analysis time.

Active Publication Date: 2021-01-22
BGI TECH SOLUTIONS
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Problems solved by technology

[0004] In view of this, the present invention provides a pathogen analysis method, device, computer equipment and readable storage medium based on high-throughput sequencing to solve the problem that current high-throughput gene detection methods for pathogens need to repeatedly compare human genomes with different Species genome, resulting in too long analysis time and technical problems of low comparison efficiency

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  • Pathogen analysis method and device based on high-throughput sequencing and computer equipment
  • Pathogen analysis method and device based on high-throughput sequencing and computer equipment
  • Pathogen analysis method and device based on high-throughput sequencing and computer equipment

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Embodiment Construction

[0064] The technical solutions in the embodiments of the present invention will be clearly and completely described below. Obviously, the described embodiments are only some of the embodiments of the present invention, but not all of them. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts belong to the protection scope of the present invention.

[0065] Glossary:

[0066] 1. High-throughput sequencing: (English: High-throughput sequencing), also known as "next-generation" sequencing technology ("Next-generation" sequencing technology), can perform parallel processing on hundreds of thousands to millions of DNA molecules at a time. Sequence determination and generally shorter read lengths etc. are the hallmarks. Sequencing refers to the analysis of the base sequence of a specific DNA fragment, that is, the arrangement of adenine (A), thymine (T), cytosine (C) and guanine (G)...

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Abstract

The invention provides a pathogen analysis method and device based on high-throughput sequencing and computer equipment, and the method comprises the steps: obtaining sequencing data of a to-be-analyzed sample, segmenting each sequence of the sequencing data according to K-mer to obtain a plurality of K-mers; performing hash calculation on the plurality of K-mers, and searching genome positions and weights corresponding to all the K-mers of each sequence in a pre-established genome hash table according to the K-mers subjected to hash calculation; calculating the total weight of each sequence according to the weights corresponding to all the K-mers of each sequence; and performing classification analysis according to the genome positions corresponding to all the K-mers of each sequence andthe total weight of each sequence, and determining species attributes of pathogens. According to the method, the species attributes can be determined only by determining the position and the weight ofthe K-mer of each sequence of the sample to be analyzed, and the accuracy is high.

Description

technical field [0001] The present invention relates to the technical field of data processing, in particular to a pathogen analysis method, device, computer equipment and readable storage medium based on high-throughput sequencing. Background technique [0002] With the gradual maturity of next-generation sequencing technology, more and more technologies based on next-generation sequencing are used in the fields of medicine and scientific research. Pathogen detection is a typical application. As we all know, a large part of the diseases that occur in humans are caused by the invasion of external pathogens, so identifying the pathogens has become the key to treating diseases and saving lives. Before next-generation sequencing technology is immature, the most common method is to determine whether the pathogen is a virus or bacteria through blood routine examination, and then use antibiotics or interferon for treatment, but this cannot efficiently target the corresponding pat...

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Application Information

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IPC IPC(8): G16B30/10G16B30/20G16B50/00
CPCG16B30/10G16B50/00G16B30/20Y02A90/10
Inventor 于闯张优劲贺增泉王今安晋向前
Owner BGI TECH SOLUTIONS
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