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Medicine for treating children bronchial asthma and preparation method thereof

A technology for bronchial asthma and medicine, which is applied in the field of medicine for treating bronchial asthma in children and its preparation field, can solve the problems of uneven particle size of powder, easy agglomeration of powder, insolubility of budesonide, etc., and achieves uniform particle size and stability. Good results

Active Publication Date: 2021-01-29
QINGDAO CENT HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, budesonide has a technical problem of poor solubility. Combining the two into an inhaler has technical problems of uneven powder particle size and easy agglomeration of the powder during storage.

Method used

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  • Medicine for treating children bronchial asthma and preparation method thereof
  • Medicine for treating children bronchial asthma and preparation method thereof
  • Medicine for treating children bronchial asthma and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027]Dissolve salbutamol: budesonide: polylactic acid: soybean lecithin in a 90% volume fraction of ethanol in a molar ratio of 1:1:0.5:0.1, stir for 1 hour, and sonicate for 1 hour at 40KHz and 40°C , And then spray drying, the spray conditions are: dry gas: nitrogen, suction rate: 100%, inlet temperature: 60℃-90℃, outlet temperature: 40℃-50℃, cooling temperature: -17℃, feeding rate : 5%-12% (1.5ml / min-3.6ml.min).

Embodiment 2

[0029]Salbutamol: budesonide: polylactic acid: soy lecithin was dissolved in a 90% ethanol aqueous solution with a volume fraction of 2:1:0.5:0.1 in a molar ratio of 2:1:0.5:0.1, stirred for 1 hour, and sonicated at 40KHz and 40°C for 1 hour. , And then spray drying, the spray conditions are: dry gas: nitrogen, suction rate: 100%, inlet temperature: 60℃-90℃, outlet temperature: 40℃-50℃, cooling temperature: -17℃, feeding rate : 5%-12% (1.5ml / min-3.6ml.min).

Embodiment 3

[0031]Salbutamol: budesonide: soy lecithin was dissolved in a 90% ethanol aqueous solution with a volume fraction of 1:1:0.1, stirred for 1 hour, and ultrasonicated for 1 hour at 40KHz, 40℃, and then spray dried , Spraying conditions are: dry gas: nitrogen, suction rate: 100%, inlet temperature: 60℃-90℃, outlet temperature: 40℃-50℃, cooling temperature: -17℃, feeding rate: 5%-12 % (1.5ml / min-3.6ml.min).

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Abstract

The invention relates to a medicine for treating bronchial asthma in children. The medicine is characterized by containing salbutamol, budesonide and soybean lecithin. By reasonably designing the formula, the medicine for treating children bronchial asthma has the advantages of being good in stability and uniform in particle size, and particle size distribution and average particle size both meetthe requirements of pulmonary inhalation preparations.

Description

Technical field[0001]The invention belongs to the technical field of pharmaceutical preparations, and specifically relates to a medicine for treating bronchial asthma in children and a preparation method thereof.Background technique[0002]Pediatric bronchial asthma is a heterogeneous disease characterized by chronic airway inflammation; it has a history of respiratory symptoms such as wheezing, shortness of breath, chest tightness, and cough, accompanied by variable expiratory airflow limitation, and respiratory symptoms and intensity can be Change over time. Asthma can occur at any age, and most of it starts before the age of 4 to 5 years. The vast majority of asthma is caused by respiratory tract infections, and the symptoms are paroxysmal attacks of cough and wheezing, which are more severe at night and in the morning. Before the attack, there may be runny nose, sneezing, and chest tightness. During the attack, breathing is difficult, and the expiration phase is prolonged with whe...

Claims

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Application Information

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IPC IPC(8): A61K9/72A61K9/16A61K47/24A61K47/34A61K31/58A61K31/137A61P11/06
CPCA61K9/1617A61K9/1641A61K31/58A61K31/137A61P11/06A61K2300/00
Inventor 于斌赵青曾鹏周洁
Owner QINGDAO CENT HOSPITAL
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