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Small-caliber tissue-improved composite artificial blood vessel

An artificial blood vessel and composite technology, applied in tissue regeneration, medical science, prosthesis, etc., can solve the problems of poor anti-thrombotic effect and inability to achieve mechanical properties, and achieve increased mechanical properties, good compliance and cytocompatibility. , the effect of promoting proliferation

Pending Publication Date: 2021-01-29
THE FIRST AFFILIATED HOSPITAL OF MEDICAL COLLEGE OF XIAN JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The technical problem to be solved by the present invention is to provide small-diameter tissue-improved composite artificial blood vessels to solve the problems of poor antithrombotic effect and inability to achieve good mechanical properties of current artificial blood vessels

Method used

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  • Small-caliber tissue-improved composite artificial blood vessel
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  • Small-caliber tissue-improved composite artificial blood vessel

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Embodiment Construction

[0028] In the following text, numerous specific details are set forth in order to provide a thorough understanding of the concepts underlying the described embodiments, however, it will be apparent to those skilled in the art that the described embodiments can be used without these specific details. Some or all instances were practiced, and in other instances well-known process steps were not described in detail.

[0029] Such as figure 1 , figure 2 , image 3 , Figure 4 , Figure 5 , Figure 6 As shown, it includes an outer layer tissue 1, an inner layer tissue 2 and a glued tissue 3, the outer layer tissue 1 is composed of a blended layer 11, micron particle holes 12 and an elastic layer of the aorta 13, and the inner layer tissue 2 Composed of decellularized endocardium 21, intimal hyperplasia layer 22 and antithrombotic drug layer 23, the glued tissue 3 is composed of N-hydroxysuccinimide 31 and carbodiimide 32, the inner layer The tissue 2 is fixed inside the oute...

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Abstract

The invention discloses a small-caliber tissue-improved composite artificial blood vessel, comprising outer-layer tissue, inner-layer tissue and cross-linked tissue, wherein the outer-layer tissue iscomposed of a blending layer, microparticle holes and an aorta elastic layer; the inner-layer tissue is composed of a decellularized endocardium, an endocardium hyperplasia layer and an antithromboticdrug layer; the cross-linked tissue is composed of N-hydroxysuccinimide and carbodiimide, the effect of facilitating vascular endothelial cell proliferation is achieved through a micropore structureat first, and then through a natural decellularization matrix material, good compliance and cell compatibility are achieved, adhesion, proliferation, differentiation and spreading of cells can be promoted, and re-endothelialization of a blood vessel is completed; an outer layer is a blending layer of silk fibroin, carboxylated bacterial cellulose and gelatin, so the mechanical properties of the blood vessel are improved, and invasion of cells such as smooth muscles is facilitated; and the inner side of an inner layer can be modified by different medicines such as heparin, so the antithrombosisof the artificial blood vessel is improved, the formation of endangium is promoted, and the reconstruction of the blood vessel is finally facilitated.

Description

technical field [0001] The invention relates to a compound artificial small blood vessel, in particular to a small-diameter tissue-improved compound artificial blood vessel. Background technique [0002] With the increasing number of people suffering from cardiovascular disease (Coronary artery disease, CAD), the demand for artificial blood vessel transplantation is increasing year by year. Clinically, large-diameter blood vessels have been well used, but small-diameter blood vessels (diameter <6 mm) made of the same material are prone to thrombosis, and the reason may be related to the performance of the graft material itself. Autologous blood vessels are considered to be the gold standard for clinical use, but the use of autologous blood vessels will cause great trauma to patients and the number of desirable ones is limited. Therefore, it is particularly important to find blood vessel materials that are similar in performance to the body's own blood vessels, have good b...

Claims

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Application Information

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IPC IPC(8): A61L27/40A61L27/50A61L27/54A61L27/20A61L27/22A61L27/36
CPCA61L27/507A61L27/54A61L27/20A61L27/222A61L27/227A61L27/3633A61L27/3687A61L27/3604A61L27/50A61L2300/42A61L2430/40
Inventor 史珂慧王丽刘华何荃王萌孙凌霜
Owner THE FIRST AFFILIATED HOSPITAL OF MEDICAL COLLEGE OF XIAN JIAOTONG UNIV
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