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Applications of semifluid containing blood, vaccine containing semifluid and preparation method of vaccine

A semi-fluid and blood technology, applied in the application of semi-fluids containing blood, vaccines containing the semi-fluids and the preparation of the vaccines, to achieve high effectiveness against pathogenic diseases, low biosafety risks, and simple and easy treatment options line effect

Inactive Publication Date: 2021-02-02
CHENGDU KUACHANGAOPU MEDICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Thus, there is still a need to develop new immunization strategies to meet urgent clinical needs that cannot be met by existing technologies

Method used

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  • Applications of semifluid containing blood, vaccine containing semifluid and preparation method of vaccine
  • Applications of semifluid containing blood, vaccine containing semifluid and preparation method of vaccine
  • Applications of semifluid containing blood, vaccine containing semifluid and preparation method of vaccine

Examples

Experimental program
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preparation example Construction

[0119]According to yet another aspect disclosed in the present application, it provides a method for preparing a vaccine for treating or inhibiting pathogenic diseases, the vaccine comprising blood as an antigen or a semi-fluid formed from blood, the method comprising the following steps:

[0120] a. Provide blood;

[0121] b. Semi-fluidizing the blood to obtain a semi-fluid, wherein the semi-fluidizing is selected from one or more of the following: viscosification of blood, coagulation of blood, and mechanical breakdown of blood coagulation.

[0122] If involved, the definitions and descriptions of the relevant terms in the foregoing aspects disclosed in the present application are also applicable to this aspect.

[0123] In one embodiment, the semi-fluidization process includes one or more of the following: semi-fluid viscosification, thermal coagulation, coagulant solidification, and wherein the thermal coagulation is selected from one of the following or Various: direct h...

Embodiment 1

[0161]Embodiment 1: the preparation of vaccine

[0162] In the following examples, the blood used is selected from one or more of the following groups:

[0163] 1) Natural blood extracted from animals;

[0164] 2) A cell-enriched natural blood fraction that is enriched to contain a fraction of blood cells (eg leukocytes or lymphocytes) and plasma. For example, blood cells concentrate blood;

[0165] 3) Engineered blood comprising part of blood cell preparations (such as leukocytes or lymphocytes) and plasma. Blood cell preparations include purified natural cells and their derivatives. For example, a mixture of plasma and purified blood cells, wherein the purified blood cells are, for example, cell pellets, white blood cell pellets, and red blood cell pellets separated from natural blood according to the prior art. Another example is a mixture of plasma and blood cell derivatives, wherein the blood cell derivatives are, for example, blood cells (such as DC cells, LAK cells,...

Embodiment 1a

[0180] Example 1a: A New Zealand rabbit was killed and 15ml of the free blood was taken, and left to stand at room temperature for 30 minutes to obtain self-coagulated blood (X1 in the above table).

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Abstract

The invention relates to applications of semifluid containing blood, a vaccine containing the semifluid, a preparation method of the vaccine and a method of resisting to pathogenic diseases.

Description

technical field [0001] The present invention relates to the use of a semi-fluid containing blood, a vaccine containing it, a method of preparing the vaccine, and a method of combating pathogenic diseases. Background technique [0002] Due to the intensity of their research, solid tumors are often used as pathogenic disease models for many serious pathogenic diseases, especially refractory pathogenic diseases. Under the pressure of the body's immune selection, cancer cells often rely on their own high mutation characteristics to gradually establish an immunosuppressive microenvironment to resist and suppress the body's immune recognition and response, and finally show the immune tolerance of the tumor body to the body. The core of solid tumor vaccine development is to develop its safe and effective antigens. Substances with multiple structural levels can be used as vaccine antigens, providing a broad space for vaccine development. [0003] Microorganisms (such as bacteria, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K39/00A61K9/00A61P35/00A61P37/04
CPCA61K9/0019A61K9/0024A61K39/0008A61K2039/515A61K2039/57A61P35/00A61P37/04
Inventor 邹方霖邹礼常王建霞王艺羲
Owner CHENGDU KUACHANGAOPU MEDICAL TECH CO LTD
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