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Preparation method of tablet medicine

A drug and tablet technology, which is applied in the field of medicine, can solve the problems of poor taste of tablets, starch does not have the ability to neutralize bitterness, and hinders the time of main ingredients, so as to achieve the effects of improving acceptance, good fluidity, and improving the taste of the mouth

Inactive Publication Date: 2021-02-05
JIANGSU PENGYAO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Traditional tablet excipients mostly choose starch, but starch has ductility after oral administration, which will hinder the time for the main drug ingredients to reach the stomach; in addition, the main drug ingredients are generally bitter, and starch does not have the ability to neutralize bitterness It will cause the taste of the whole tablet to be poor, not suitable for the elderly

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Get 100 parts of main drug components by weight, 5 parts of sodium carboxymethyl starch, 10 parts of low-substituted cellulose and 3 parts of additives stand-by, the main drug components are preferably carbamazepine, and the additives are carbamazepine Magnesium fatty acid; pass sodium carboxymethyl starch and low-substituted cellulose through a 400-mesh sieve and mix at room temperature. After mixing for 20-40 minutes, add the additives to the main ingredient, and mix in a centrifugal mixer for 1-2 hours at room temperature. Then add it to the granulator for granulation.

Embodiment 2

[0018] Get 100 parts of main drug components by weight, 6 parts of sodium carboxymethyl starch, 9 parts of low-substituted cellulose and 4 parts of additives stand-by, the main drug component is preferably amlodipine besylate, said The additive is vitamin D3; pass sodium carboxymethyl starch and low-substituted cellulose through a 400-mesh sieve and mix at room temperature. After mixing for 20 to 40 minutes, add the additive to the main ingredient, and mix in a centrifugal mixer for 1 to 2 hours at room temperature. , and then add it to the granulator for granulation.

Embodiment 3

[0020] Get 100 parts of main drug components by weight, 7 parts of sodium carboxymethyl starch, 8 parts of low-substituted cellulose and 5 parts of additives stand-by, the main drug component is preferably fludrocortisone acetate, said The additive is D-glucosamine sulfate potassium salt; the sodium carboxymethyl starch and the low-substituted cellulose are respectively passed through a 400-mesh sieve and then mixed at room temperature. After mixing for 20-40 minutes, the additive is added to the main ingredient, and the mixture is placed in a centrifugal mixer at room temperature. Mix for 1~2 hours, then add to the granulator for granulation.

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PUM

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Abstract

The invention discloses a preparation method of a tablet medicine. The preparation method of the tablet medicine comprises the following steps: taking 100 parts by weight of a main medicine component,5-10 parts by weight of sodium carboxymethyl starch, 5-10 parts by weight of low-substituted cellulose, and 3-5 parts by weight of an additive; respectively sieving the sodium carboxymethyl starch and the low-substituted cellulose through a 400-mesh sieve; carrying out mixing at normal temperature for 20-40 minutes so as to obtain a mixture; adding the mixture with the additive into the main medicine component; carrying out mixing for 1-2 hours at normal temperature in a centrifugal stirrer so as to obtain a stirred material; and then, putting the stirred material into a granulator for granulation. According to the preparation method of the tablet medicine, magnesium stearate, vitamin D3 or D-glucosamine potassium sulphate is used in replacement of starch, so that the whole tablet has good fluidity; and moreover, the D-glucosamine potassium sulphate has certain sweetness, so that the mouth feel of the whole tablet can be improved so as to improve acceptability by the human body.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a preparation method of tablet medicine. Background technique [0002] A tablet is a tablet-shaped or shaped tablet-shaped solid preparation that is uniformly mixed with drugs and excipients and compressed. The general preparation process is to pulverize, granulate, and dry the material first, and then use a tablet machine to form a tablet, and some do not need granulation and drying, and are directly compressed into tablets. [0003] Traditional tablet excipients mostly choose starch, but starch has ductility after oral administration, which will hinder the time for the main drug ingredients to reach the stomach; in addition, the main drug ingredients are generally bitter, and starch does not have the ability to neutralize bitterness It will lead to poor mouthfeel of the whole tablet, which is not suitable for the elderly. Contents of the invention [0004] Purpose of the...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K47/38A61K47/36A61K47/26A61K47/12A61K47/22A61K31/13A61K31/166A61K31/4422A61K31/55A61K31/573
CPCA61K9/2059A61K9/2054A61K9/2018A61K9/2013A61K9/2095A61K31/166A61K31/55A61K31/4422A61K31/573A61K31/13
Inventor 周健蒋锋扶文君王顺侯珂兰
Owner JIANGSU PENGYAO PHARMA