Process preparation method for one-pot synthesis of bis-ethylhexyloxyphenol methoxyphenyl triazine

Abstract

The invention discloses a process preparation method for synthesizing bis-ethylhexyloxyphenol methoxyphenyl triazine in one pot. When synthesizing RET, the invention uses toluene and benzonitrile as the dispersion system of aluminum trichloride, In order to reduce the toxic effect of sulfone solvents on the human body; after synthesizing RET, directly destroy the system, dissolve the system RET with N,N-dimethylformamide, use weak alkali carbonate as an acid-binding agent, and react with chlorine Substituting isooctane for etherification reaction, after the etherification is completed, directly wash with water to remove the waste salt produced in the above steps. This process fundamentally solves the problems of a large amount of water washing and particularly difficult filtration in the RET synthesis process, and directly uses the RET reaction system to carry out reflux and water separation for etherification reaction. The selectivity of etherification has also been improved to a certain extent, and the finished product of bis-ethylhexyloxyphenol methoxyphenyl triazine with a chromatographic purity greater than 99% is finally obtained, and the total yield of the two steps has reached more than 85.5%.

Description

Process preparation method for one-pot synthesis of bis-ethylhexyloxyphenol methoxyphenyl triazine technical field The invention belongs to technical field of chemical industry, be specifically related to a kind of one-pot method synthesizing bis-ethylhexyloxyphenol methoxyphenyl Process preparation method of triazine. Background technique Two-ethylhexyloxyphenol methoxyphenyl triazine, has another name called Tinosorb S, trade name Bemotrizinol, is called for short BTZ, CAS No: 187393‑00‑6, Molecular formula: C 38 H 49 N 3 O 5 , molecular weight: 627.81g / mol, the chemical structure is as follows: [0003] Bis-ethylhexyloxyphenol methoxyphenyl triazine is a kind of oil-soluble organic compound, is added in sunscreen lotion to absorb To absorb ultraviolet rays, bis-ethylhexyloxyphenol methoxyphenyl triazine is a wide range of ultraviolet absorbers, which can absorb UVB and even UVA, It has two absorption peaks, located at wavelengths 310 and 340 nm, ...

AI Technical Summary

Problems solved by technology

This process fundamentally solves the problems of a large amount of water washing and particularly difficult filtration during the RET synthesis process, and directly uses the RET reaction system to reflux and divide water for etherification reaction, and bis-ethylhexyloxyphenol methoxyphenyl triazine The selectivity of etherification has also been improved to a certain extent, and the finished product of bis-ethylhexyloxyphenol methoxyphenyl triazine with a chromatographic purity greater than 99% is finally obtained, and the total yield of the two steps has reached more than 85.5%, thus completing the this invention

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