Catalysis alcoholysis method used for producing and preparing [beta]-thymidine

Abstract

The invention discloses a catalysis alcoholysis method used for producing and preparing [beta]-thymidine. The catalysis alcoholysis method comprises a raw material tank, a first reaction tank, a second reaction tank and a third reaction tank, wherein the right side of the raw material tank communicates with the left side of a mixing and material adding tank; the lower end of the mixing and material adding tank communicates with the upper end of a large sieving device through a pipeline; the right end of the first reaction tank, the right end of the second reaction tank and the right end of thethird reaction tank are independently connected with the left end of a first catalysis tank, the left end of a second catalysis tank and the left end of a third catalysis tank; in addition, the upperend of the first reaction tank, the upper end of the second reaction tank and the upper end of the third reaction tank are connected with the lower end of the large sieving device; and in addition, the lower end of the first catalysis tank, the lower end of the second catalysis tank and the lower end of the third catalysis tank are connected with the upper end of a finished product cabin. The alcoholysis method used for producing and preparing the [beta]-thymidine has various catalysis ways, is high in efficiency and can meet alcoholysis requirements under different temperatures. Meanwhile, asieving system is arranged so as to be more convenient in use, and the market utilization requirements at present can be met.

Description

technical field [0001] The invention relates to the technical field of production and preparation of β-thymidine, in particular to a catalytic alcoholysis method for production and preparation of β-thymidine. Background technique [0002] β-thymidine, also known as deoxythymidine, is the key intermediate for the treatment of AIDS drug zidovudine, and for the production of β-thymidine, D-ribose is often used as the starting material, and after condensation, halogenation Acylation, catalytic hydrogenation reduction, and catalytic alcoholysis to prepare β-thymidine, but the catalytic alcoholysis method for the production and preparation of β-thymidine on the market still has the following problems: [0003] 1. The existing catalytic alcoholysis method for the production and preparation of β-thymidine has only one catalytic method, which cannot meet the catalytic demand in the case of failure, so it cannot improve the production efficiency of β-thymidine and cannot meet the use ...

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Problems solved by technology

[0007] The purpose of the present invention is to provide a catalytic alcoholysis method for the production and preparation of β-thymidine, so as to solve the above-mentioned background technology. Catalytic requirements cannot be met, so the preparation efficiency of β-thymidine cannot be improved, the use requirements cannot be met, there is no screening system, the prepared β-thymidine is not high in purity, and the layers are uneven, which cannot meet the requirements of β-thymidine The preparation requirements and the alcoholysis at different temperatures cannot be met, so the requirements for the alcoholysis environment are high, and it is inconvenient to use

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