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Preparation method and applications of active matter capable of efficiently removing chloasma

A technology for actives and freckle removal. It is used in medical preparations containing active ingredients, preparations for skin care, and drug combinations. It can solve problems such as less use, and achieve enhanced solubility and penetration, which is conducive to efficient extraction and improvement. The effect of comprehensive utilization

Active Publication Date: 2021-02-23
PROYA COSMETICS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] As a traditional Chinese herbal medicine with both medicine and food in our country, Artemisia argyi often appears in anti-inflammatory prescriptions, and it is rarely used alone

Method used

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  • Preparation method and applications of active matter capable of efficiently removing chloasma
  • Preparation method and applications of active matter capable of efficiently removing chloasma
  • Preparation method and applications of active matter capable of efficiently removing chloasma

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0063] Embodiment 1: a kind of preparation method of highly efficient freckle-removing active substance is characterized in that: the following steps are adopted:

[0064] A. Pick fresh mugwort leaves, spread them flat on a drying sieve and dry them in a dryer for 6 hours at a drying temperature of 60°C until the water content of the mugwort leaves is less than 2% to obtain dried mugwort leaves; weigh an appropriate amount of dried mugwort leaves and add them to the Bottom flask, then add deionized water, the quality of deionized water is 5 times the quality of dry Artemisia argyi; use chemically pure concentrated hydrochloric acid to adjust the pH of the liquid in the flask to 2.0, place the round bottom flask in a 75°C water bath for heating and extraction, The liquid outlet of the condenser tube is used to receive the Artemisia argyi essential oil in an Erlenmeyer flask equipped with deionized water; when the yellow oily liquid is no longer produced after heating, stop heati...

Embodiment 2

[0069] A preparation method of high-efficiency freckle-removing active substances, characterized in that: the following steps are adopted:

[0070] A. Pick fresh mugwort leaves, spread them flat on a drying sieve and dry them in a dryer for 7 hours at 60°C until the water content of the mugwort leaves is less than 2% to obtain dried mugwort leaves; weigh an appropriate amount of dried mugwort leaves and add them to the Bottom flask, then add deionized water, the quality of deionized water is 8 times the quality of dried Artemisia argyi; use chemically pure concentrated hydrochloric acid to adjust the pH of the liquid in the flask to 2.5, place the round bottom flask in a water bath at 85°C for heating and extraction, The liquid outlet of the condenser tube is used to receive the Artemisia argyi essential oil in an Erlenmeyer flask equipped with deionized water; when the yellow oily liquid is no longer produced after heating, stop heating and extraction; filter the mixture in th...

Embodiment 3

[0075] A preparation method of high-efficiency freckle-removing active substances, characterized in that: the following steps are adopted:

[0076] A. Pick fresh mugwort leaves, spread them flat on a drying sieve and dry them in a dryer for 8 hours at 60°C until the water content of the mugwort leaves is less than 2% to obtain dried mugwort leaves; weigh an appropriate amount of dried mugwort leaves and add them to the Bottom flask, then add deionized water, the quality of deionized water is 10 times the quality of dried Artemisia argyi; use chemically pure concentrated hydrochloric acid to adjust the pH of the liquid in the flask to 3.0, place the round bottom flask in a 95°C water bath for heating and extraction, The liquid outlet of the condenser tube is used to receive the Artemisia argyi essential oil in an Erlenmeyer flask equipped with deionized water; when the yellow oily liquid is no longer produced after heating, stop heating and extraction; filter the mixture in the ...

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Abstract

The invention relates to a preparation method and applications of an active matter capable of efficiently removing chloasma. The preparation method and applications are characterized in that the preparation method includes the following steps: A, drying fresh folium artemisiae argyi to add into a round-bottom flask with deionized water, adjusting pH to 2.0-3.0 with concentrated hydrochloric acid,performing heating extraction through a water bath, receiving folium artemisiae argyi essential oil with a taper flask at the liquid outlet of a condensing tube, performing water bath extraction on the first filtered residue under the environment where the pH is 6.5-7.0, and performing water bath extraction on the second filtered residue under the environment where the pH is 8.2-8.6; B, pooling the first filtrate, the second filtrate and the third filtrate after filtration so as to obtain a folium artemisiae argyi extracting solution; C, performing reduced pressure distillation and concentration on the folium artemisiae argyi extracting solution to obtain folium artemisiae argyi extract, taking a proper amount of the extract to add into an ethanol / ammonium sulfate aqueous two-phase system,adjusting the pH to 3-4 with the concentrated hydrochloric acid, performing full shaking, then allowing the solution to stand, collecting an ethanol phase at the upper layer, and obtaining folium artemisiae argyi flavonoids through vacuum concentration; and D, mixing the folium artemisiae argyi essential oil and the folium artemisiae argyi flavonoids so as to obtain the active matter capable of efficiently removing chloasma. The obtained active matter has good effects on improving the chloasma.

Description

[0001] technical background [0002] Melasma is a pigmentation disease that occurs mostly on the face of women. Its clinical reaction is mainly light brown to dark brown pigmented spots, some with a certain degree of skin lesions, mostly distributed on the face, cheeks, cheeks, nose and other parts. The pathogenic mechanism of chloasma is relatively complicated. At present, it is believed that the main factors leading to chloasma are endocrine, heredity, sunlight exposure, free radicals and so on. Therefore, if you want to improve chloasma, you must not only pay attention to the adjustment of mood, reduce sunlight exposure, but also control free radicals and inflammation. [0003] Referring to the literature at home and abroad, we can see that the main interventions for melasma include topical drugs, chemical peels, laser therapy, and oral medication. Among the many melasma intervention methods of cosmetics, the most commonly used whitening agents are fruit acid and its deriva...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/282A61K8/9789A61K8/92A61P17/00A61Q19/02A61K127/00
CPCA61K8/922A61K36/282A61K2800/782A61K2800/805A61Q19/02A61K8/9789A61P17/00A61K2300/00
Inventor 李悦黄洁芳朱士强毕永贤蒋丽刚刘晓青金凤席长洪
Owner PROYA COSMETICS
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