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Application of JingFang preparation in preparation of medicine for treating sequelae of novel coronavirus disease and preparation method thereof

A technology of sequelae and preparations, applied in the field of medicine, can solve problems that affect the quality of life and poor prognosis

Pending Publication Date: 2021-02-23
LUNAN PHARMA GROUP CORPORATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, although some discharged patients have negative nucleic acid tests, pneumonia relief or obvious absorption, and normal body temperature, they may still have symptoms such as fatigue, shortness of breath, loss of appetite, diarrhea, and anxiety. Pulmonary fibrosis affects the quality of life, especially the elderly and those with chronic underlying diseases have a poor prognosis

Method used

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  • Application of JingFang preparation in preparation of medicine for treating sequelae of novel coronavirus disease and preparation method thereof
  • Application of JingFang preparation in preparation of medicine for treating sequelae of novel coronavirus disease and preparation method thereof
  • Application of JingFang preparation in preparation of medicine for treating sequelae of novel coronavirus disease and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0122] The preparation of embodiment 1 Jingfang granules

[0123]

[0124]

[0125] A. Nepeta, Fangfeng, Notopterygium, Duhuo, Peucedanum, Chuanxiong and Citrus aurantium were extracted to obtain volatile oils of 7 kinds of medicinal materials, and the distilled medicinal residues, Chuanxiong and Citrus aurantium distilled aqueous solution were used for later use;

[0126] B. Get the volatile oil gained in step A, add β-cyclodextrin respectively to make clathrate;

[0127] C. the distilled aqueous solution of Rhizoma Chuanxiong and Fructus Fructus Fructus obtained in step A is made into 27% ethanol solution as a solvent, and the medicinal residues of Rhizoma Chuanxiong and Fructus Fructus Fructus Fructus obtained in step A are percolated with Poria cocos to obtain percolating liquid for subsequent use;

[0128] D. Decoct the medicinal residues of Schizonepeta, Fangfeng, Notopterygium, Duhuo and Peucedanum obtained in step A with the rest of Bupleurum, Campanulaceae, Lico...

Embodiment 2

[0131] The preparation of embodiment 2 Jingfang tablets

[0132]

[0133] A. Nepeta, Fangfeng, Notopterygium, Duhuo, Peucedanum, Chuanxiong and Citrus aurantium were extracted to obtain volatile oils of 7 kinds of medicinal materials, and the distilled medicinal residues, Chuanxiong and Citrus aurantium distilled aqueous solution were used for later use;

[0134] B. Get the volatile oil gained in step A, add β-cyclodextrin respectively to make clathrate;

[0135] C. the distilled aqueous solution of Rhizoma Chuanxiong and Fructus Aurantii obtained in step A is made into 24% ethanol solution as a solvent, and the medicinal residues of Rhizoma Chuanxiong and Fructus Fructus Fructus obtained in step A are percolated with Poria cocos to obtain percolation liquid for subsequent use;

[0136] D. Decoct the medicinal residues of Schizonepeta, Fangfeng, Notopterygium, Duhuo, and Peucedanum obtained in step A with the rest of Bupleurum, Campanulaceae, and Licorice, and decoct twice ...

Embodiment 3

[0139] The preparation of embodiment 3 Jingfang microcapsules

[0140]

[0141] A. Nepeta, Fangfeng, Notopterygium, Duhuo, Peucedanum, Chuanxiong and Citrus aurantium were extracted to obtain volatile oils of 7 kinds of medicinal materials, and the distilled medicinal residues, Chuanxiong and Citrus aurantium distilled aqueous solution were used for later use;

[0142] B. Get the volatile oil gained in step A, add β-cyclodextrin respectively to make clathrate;

[0143] C. the distilled aqueous solution of Rhizoma Chuanxiong and Fructus Fructus Fructus obtained in step A is made into 29% ethanol solution as a solvent, and the medicinal residues of Rhizoma Chuanxiong and Fructus Fructus Fructus obtained in step A are percolated with Poria cocos to obtain percolation liquid for subsequent use;

[0144] D. Decoct the medicinal residues of Schizonepeta, Fangfeng, Notopterygium, Duhuo and Peucedanum obtained in step A with the rest of Bupleurum, Campanulaceae, Licorice and other ...

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Abstract

The invention discloses application of a Jingfang preparation in preparation of a medicine for treating sequelae of the novel coronavirus disease and a preparation method thereof, and belongs to the field of medicines. The Jingfang preparation is prepared from eleven raw medicinal materials such as fineleaf schizonepeta herb, divaricate saposhnikovia root, notopterygium root, doubleteeth pubescentangelica root, Chinese thorowax root, common hogfennel root, szechuan lovage rhizome, bitter orange, Indian buead, platycodon root and liquoric root, and has the effects of sweating, relieving exterior, dispersing wind and removing dampness. The Jingfang preparation is an effective formula for treating sequelae of the novel coronavirus disease, can effectively treat viral myocarditis of patientswith the novel coronavirus disease in the convalescence, reduce the serum concentration of liver function markers ALT and AST and renal function markers Cre and BUN, thereby effectively protecting liver and kidney functions, effectively inhibit inflammatory response of acute respiratory distress syndrome and effectively treat diarrhea. Both symptoms and root causes are treated, and definite therapeutic effect is achieved on the sequelae of the novel coronavirus disease.

Description

technical field [0001] The present invention relates to the application of Jingfang preparation and its preparation method, in particular to the application and preparation method of Jingfang preparation in the preparation of drugs for the treatment of sequelae of new crown, and belongs to the field of medicine. Background technique [0002] Corona Virus Disease 2019 (COVID-19), referred to as "New Coronary Pneumonia", refers to the acute infectious pneumonia caused by the 2019 novel coronavirus infection. The most common clinical symptoms of infected patients are fever, fatigue, and dry cough, and a small number of patients are accompanied by upper respiratory and digestive tract symptoms such as nasal congestion, runny nose, and diarrhea. Severe cases often develop dyspnea one week later, and severe cases further develop into acute respiratory distress syndrome, septic shock, difficult-to-correct metabolic acidosis, and coagulation dysfunction. COVID-19 is a multi-system ...

Claims

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Application Information

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IPC IPC(8): A61K36/752A61P31/14
CPCA61K36/076A61K36/23A61K36/232A61K36/233A61K36/236A61K36/237A61K36/238A61K36/346A61K36/484A61K36/538A61K36/752A61P31/14A61K2300/00
Inventor 张贵民关永霞程国良李冰冰
Owner LUNAN PHARMA GROUP CORPORATION
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