Atrial fibrillation animal model simulation method

Abstract

The invention discloses an atrial fibrillation animal model simulation method. The atrial fibrillation animal model simulation method comprises the steps that 1, experimental dogs are prepared; namely, a plurality of adult beagles are selected, all experimental dogs are subjected to skin preparation by using electric hair clippers before an operation, wherein the skin preparation part comprises bilateral necks, bilateral groin areas, a chest part, a waist and back part L2-L3 area and four limbs; 2, an electrocardiogram monitor is implanted into each experimental dog; program control is carriedout after an operation, tracker working parameters are set, and loads are recorded; 3, a dog right atrium rapid pace-making system is established; and 4, an atrial fibrillation animal model is established, a high-frequency atrial fibrillation model pacemaker is controlled to be programmed into a pace-making mode by using an in-vitro pacemaker system program controller for the experimental dog after the operation in the step 3, and the output, pulse width and the like of the pacemaker are set. The beneficial effects of the method are that the method carries out the modeling simulation of the atrial fibrillation in dogs, provides a scientific basis for the searching of a new atrial fibrillation treatment strategy, and facilitates the subsequent clinical experiment.

Description

technical field [0001] The invention relates to the medical field, in particular to a method for simulating an animal model of atrial fibrillation. Background technique [0002] The incidence of atrial fibrillation varies with age, lung disease, intraatrial block, intraatrial reentry, and atrial electro-anatomic remodeling in organic cardiovascular disease and caused by metabolic abnormalities, toxic drugs, traumatic stress, neuroendocrine disorders or Gene abnormalities are elevated. [0003] Atrial fibrillation is the most common tachyarrhythmia, which seriously endangers the health of the crowd, often leading to heart failure, arrhythmia sudden death and ischemic stroke and other diseases. There is still a lack of efficient, safe, economical, and ideal treatment methods. Therefore, in-depth research on the pathogenesis of atrial fibrillation, better treatment methods, and exploration of related intervention targets have always been research hotspots and priorities in the...

AI Technical Summary

Problems solved by technology

[0003] Atrial fibrillation is the most common tachyarrhythmia, which seriously endangers the health of the crowd, often leading to heart failure, arrhythmia sudden death and ischemic stroke and other diseases. There is still a lack of efficient, safe, economical, and ideal treatment methods. Therefore, in-depth research on the pathogenesis of atrial fibrillation, better treatment methods, and exploration of related intervention targets have always been research hotspots and priorities in the field of electrophysiology.

In order to carry out in-depth research on atrial fibrillation, it is very important to establish a stable and reliable animal model of the disease. However, in the process of research, humans cannot be used as experimental research objects. Therefore, we do not know enough about the mechanism of atrial fibrillation.