Open-loop sampling system for medicine dissolution through flow cell method and use method

A sampling system and flow cell technology, which is applied in the field of open-loop sampling system for drug dissolution by flow cell method, can solve the problems of not compact enough structure, large floor area, and difficulty in controlling the heat exchange temperature of solvents, etc.
CN112504750APending Publication Date: 2021-03-16禄亘(上海)生命科技有限公司
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
禄亘(上海)生命科技有限公司
Publication Date
2021-03-16

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Abstract

The invention discloses an open-loop sampling system for medicine dissolution through a flow cell method and a using method. A constant-temperature water area system comprises a constant-temperature water tank rack, a constant-temperature water tank and a solvent cup holder. A flow cell system is arranged at the top end of the constant-temperature water area system and comprises a flow cell rack,a flow cell and a glass tube; a lifting mechanism is arranged on one side of the constant-temperature water tank rack; a circulating heating system comprises a heating device and a water circulating pump; a solvent monitoring system is arranged at the top end of the heating device; a solvent switching system is arranged on one side of the constant-temperature water area system; a solvent mixing system comprises a solvent mixing seat, a solvent mixer and a solvent suction pump; a solvent circulating system comprises a solvent circulating pump and a pulse valve; a sampling system comprises a sampling mechanism, a sampling pipeline and a sampling valve. According to the invention, an open type solvent sampling process can be carried out on a solvent, the heating device of the solvent is stably fixed, the heating efficiency is high, the temperature is accurately controlled, the pH value of the solvent can be switched and adjusted, and the real dissolution environment of human gastrointestinal tracts is simulated.
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Description

technical field

[0001] The invention relates to the technical field of application of medical experimental equipment, in particular to an open-loop sampling system for drug dissolution by a flow cell method and a use method thereof. Background technique

[0002] The rapid development of pharmaceutical technology, accompanied by the birth of a large number of new drugs and the current requirements for the in vitro and in vivo correlation (IVIVC) of the dissolution test method, the traditional dissolution test methods (paddle method, basket method, etc.) Encountered many new problems, such as the determination of trace pharmaceutical preparations, the formulation of new pharmaceuticals such as patches and microspheres, and how to solve the in vivo and in vitro correlations of immediate-release preparations. As a new test method for dissolution concentration, the flow cell method mainly relies on the continuous flushing of preparations with flowing solvents, which can well simu...

Claims

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