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Oil-in-water emulsion composition and external preparation for skin

An emulsified composition, oil-in-water type technology, applied in skin care preparations, cosmetics, dressing preparations, etc., can solve the problems of high skin permeability, difficult deployment, and difficulty in dissolving tetrahydropiperine in aqueous media, etc. Achieve excellent time stability and good sebum compliance

Pending Publication Date: 2021-03-30
FUJIFILM CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Tetrahydropiperine is a component that is difficult to dissolve in water-based media when it is a monomer, so it is difficult to mix it with water-based cosmetics
For example, if tetrahydropiperine is dispersed in the state of solid particles and formulated as a solid dispersion, high skin permeability of tetrahydropiperine when applied to the skin cannot be expected.

Method used

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  • Oil-in-water emulsion composition and external preparation for skin
  • Oil-in-water emulsion composition and external preparation for skin
  • Oil-in-water emulsion composition and external preparation for skin

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0209] Each component constituting the oil phase composition described in the following Table 2 was put into a container, and stirred with a stirrer for 1 hour in a constant temperature water tank at 80° C., thereby obtaining an oil phase composition. Next, each component constituting the water-phase composition described in the following Table 2 was put into a container, and stirred using a stirrer for 1 hour in a constant temperature water tank at 80° C., thereby obtaining a water-phase composition.

[0210] Next, the water-phase composition was stirred using a stirrer in an 80° C. constant-temperature water tank, and the oil-phase composition was gradually added to the water-phase composition being stirred to obtain a liquid mixture. Using an ultrasonic homogenizer [Model: US600-AT, NIHONSEIKIKAISHA LTD.], the obtained mixed solution was subjected to a dispersion treatment for one minute per 100 g of the mixed solution to obtain a rough dispersion. Next, using a high-pressu...

Embodiment 2 and Embodiment 3

[0212] In Example 2 and Example 3, except that the composition of the oil phase composition was changed to the composition described in Table 2, the same operation as in Example 1 was carried out, and each water in Example 2 and Example 3 was obtained. Oil-in-emulsion composition.

Embodiment 4～ Embodiment 7

[0214] In Examples 4 to 7, except that the composition of the oil phase composition was changed to the composition described in Table 3, the same operation as in Example 1 was carried out to obtain the water compositions of Examples 4 to 7. Oil-in-emulsion composition.

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Abstract

Provided are: an oil-in-water emulsion composition which contains tetrahydropiperine, has good sebum compliance, and has excellent temporal stability at low temperatures; and an external preparation for skin. The oil-in-water emulsion composition comprises tetrahydropiperine, an oil component, an emulsifier and water, wherein the oil component has a value of the ratio of an inorganic value to an organic value being greater than 0.16 and less than 0.40.

Description

technical field [0001] The invention relates to an oil-in-water emulsified composition and an external preparation for skin. Background technique [0002] Tetrahydropiperine is known as a component obtained from black pepper, and is known to have actions such as promoting percutaneous absorption and promoting blood circulation. As a technique utilizing such an action of tetrahydropiperine, for example, Patent Document 1 discloses a method of improving the utilization ability of nutrients, drugs, etc. in vivo by supplying nutrients, drugs, etc. together with tetrahydropiperine. [0003] Patent Document 1: Japanese National Publication No. 2003-534295 [0004] Tetrahydropiperine is a component that is difficult to dissolve in an aqueous medium when it is a monomer, and therefore it is difficult to mix it with an aqueous cosmetic. For example, if tetrahydropiperine is dispersed in the state of solid particles and formulated as a solid dispersion, high skin permeability of tet...

Claims

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Application Information

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IPC IPC(8): A61K8/06A61K8/34A61K8/37A61K8/49A61K8/55A61K8/60A61K8/86A61Q19/00
CPCA61K8/062A61K8/4926A61K8/37A61K8/553A61K8/86A61K8/602A61K8/345A61Q19/00A61K2800/10
Inventor 河野贵胤柳辉一
Owner FUJIFILM CORP
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