2results about How to "Good time stability" patented technology

This invention belongs to the field of analytical detection and probes, specifically relating to an activated reactive oxygen species (ROS) fluorescence lifetime probe and its construction method. The probe uses 1-hexylheptamethylaluminol dye as the target recognition unit and energy acceptor, and lanthanide nanoparticles as the energy donor. The energy acceptor and energy donor are connected by an amphiphilic polymer to construct a fluorescence resonance energy transfer (FRET) system, which shortens the fluorescence lifetime of the lanthanide nanoparticles. When the target analyte ROS is present, the 1-hexylheptamethylaluminol dye recognizes the target analyte, thereby disrupting the FRET and restoring the fluorescence lifetime of the lanthanide nanoparticles, thus enabling the detection of ROS. The activated ROS fluorescence lifetime probe constructed in this invention introduces a 1-hexylheptamethylaluminol dye with a specific structure as an energy acceptor, effectively solving the problem of insufficient energy acceptors in existing fluorescence lifetime probes by indirectly regulating lifetime, and providing a new idea and strategy for the design and construction of near-infrared II fluorescence lifetime probes.

The present application relates to the technical field of mechanical sensing test, in particular to a flexible sensor for force monitoring, a preparation method and a regulation and control mechanical loading system. The flexible sensor of the present application can realize real-time monitoring of the mechanical force required for wound closure and maintenance by setting two strain sensors, while reducing the error influence of the skin's own appearance, realizing that the difference change of the resistance of the two strain sensors is proportional to the tension force generated by the stretched skin, improving the linearity of the sensor; and effectively inhibiting the influence of bending, ensuring that the sensing output is not sensitive to the curvature of the substrate, reducing signal drift, thereby improving the accuracy of the force monitoring result and the data reliability. The regulation and control mechanical loading system of the present application arranges multiple guide holes on the flexible insulating substrate along the force monitoring direction, inserts guide pins into the guide holes corresponding to different positions on the flexible sensor, and realizes controllable and adjustable mechanical loading.